REVIEW article
Front. Immunol.
Sec. Microbial Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1695840
This article is part of the Research TopicAdvances in Immunity and Microbiome: Exploring Key Interactions and InnovationsView all 18 articles
The Crosstalk Between Probiotics and T Cell Immunity
Provisionally accepted
- 1Shanghai Jiao Tong University, Shanghai, China
- 2Hebei Academy of sciences, Shijiazhuang, China
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Probiotic supplementation is one of the most widely well-recognized approaches for health maintaining. Distinct probiotics have been experimentally and mechanically investigated for their possible effectiveness in treating autoimmune disease, metabolic diseases, and cancer immune therapy, showing extensive and promising therapeutic potential. Focusing on the T cell mediated responses and diseases, this review specifically aims to elucidate the intricate crosstalk between probiotic microorganisms and T cells, exploring how probiotics modulate the differentiation, activation, proliferation, and functional states of different T cell subsets, such as CD4+ T cells and CD8+ T cells, thereby influencing the overall immune response and immune homeostasis. By revealing this crosstalk, we aim to uncover the potential of probiotics in immune regulation and disease prevention, providing valuable insights for developing novel therapeutic strategies and preventive measures leveraging the probiotics-T cell axis.
Keywords: Probiotics, T Cell Immunity, Inflammation, cancer immunotherapy, Metabolites
Received: 30 Aug 2025; Accepted: 09 Oct 2025.
Copyright: © 2025 ZHANG, LIU, Liu and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: WENCAN ZHANG, wenczhang@sjtu.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.