CASE REPORT article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1696940
This article is part of the Research TopicMechanisms Regulating Immune Evasion by B-cell LymphomaView all 3 articles
Case Report: Epstein-Barr Virus-Positive Follicular Lymphoma With High PD-L1 Expression
Provisionally accepted
- 1Yantai Yuhuangding Hospital Department of Pathology, Yantai, China
- 2Department of Pathology,Haiyang Hospital of Traditional Chinese Medicine,ShandongProvince,Yantai,China, Yantai, China
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[Abstract] Background:Follicular lymphoma is a common B-cell lymphoma and is classified as an indolent lymphoma, more frequently seen in middle-aged and elderly individuals.In recent years, considerable research has been conducted on follicular lymphoma; however, cases of Epstein-Barr virus (EBV)-positive follicular lymphoma remain rare.Notably, follicular lymphoma with EBV positivity accompanied by high PD-L1 expression has not been reported..Case Presentation:We present a case of EBV-positive follicular lymphoma with high PD-L1 expression and analyze its clinicopathological features.,The patient was treated with R-CHOP chemotherapy combined with the anti-CD20 antibody (rituximab), achieving favorable therapeutic outcomes. This case provides valuable insights for the pathological diagnosis and treatment of EBV-positive follicular lymphoma, as well as the role of EBV infection in PD-L1 expression. Furthermore, it raises the question of whether high PD-L1 expression suggests that immunotherapy could serve as another potential treatment strategy for EBV-positive follicular lymphoma.aiming to provide a foundation for the pathological diagnosis of EBV-positive follicular lymphoma, explore potential new treatment strategies, and investigate the role of EBV infection in PD-L1 expression.
Keywords: follicular lymphoma, High PD-L1 expression, mechanisms, Treatment, Epstein-Barr virus-positive
Received: 01 Sep 2025; Accepted: 29 Sep 2025.
Copyright: © 2025 Zheng, Wang, Pan, Sui and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guohua Yu, guohuayu@qdu.edu.cn
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