From Metabolic Alterations to Chronic Inflammation: Mechanisms and Immunoregulation of Metabolic Reprogramming in COPD

Siyu Zeng¹Yanqiu 3096972236@qq.com¹Shiran Li¹Zhimin Li¹Pengfei Li¹Jingxian Xie^2,3JIAO ZHANG¹Yong Yang^1*

• ¹Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Chengdu, China
• ²Southwest Medical University, Luzhou, China
• ³Sichuan Academy of Medical Sciences and Sichuan People's Hospital, Chengdu, China

Chronic obstructive pulmonary disease (COPD) is a prevalent chronic respiratory disease characterized by high prevalence, mortality, and disease burden. Current understanding of COPD pathogenesis primarily focuses on airway inflammation, immune dysfunction, oxidative stress, and protease-antiprotease imbalance. Notably, recent studies have increasingly highlighted the role of metabolic reprogramming in COPD. Metabolic reprogramming refers to cellular adaptation through metabolic pathway alterations in response to environmental stress, enabling physiological or pathological state transitions. This review systematically summarizes COPD pathogenesis, with particular focus on metabolic reprogramming features (glucose, lipid, and amino acid metabolism) in immune cells from COPD experimental models. Furthermore, we analyze the interactions between these metabolic alterations and chronic inflammatory responses, providing new insights into COPD pathogenesis.