REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
This article is part of the Research TopicImmune Cell Dynamics in Chronic Inflammatory Diseases and Cancer ImmunopathologyView all 6 articles
Emerging Roles for Methionine Metabolism in Immune Cell Fate and Function
Provisionally accepted
- 1Agricultural products processing research institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang, Guangdong, 524000, China, Zhanjiang, China
- 2College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China
- 3College of Animal Science and Technology · College of Veterinary Medicine, Zhejiang A&F University, Hangzhou, China
- 4Chinese Academy of Tropical Agricultural Sciences South Subtropical Crop Research Institute, Zhanjiang, China
- 5Key Laboratory of Feed Biotechnology of Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing, China
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Metabolic reprogramming is a critical characteristic essential for the activation of immune cells. The altered amino acid metabolism, particularly changes in methionine metabolism, holds significant importance in directing the fate and function of diverse immune cells. Here we summarize the main transport system and metabolic pathway of methionine in immune cells, and the well-established and novel research findings of methionine metabolism-dependent modulation on major immune cell lineages and cancer cells are provided afterward. Unraveling the potential regulatory mechanism of methionine metabolism reprogramming in immune cells provides the new strategies for the therapy of autoimmune diseases and cancers.
Keywords: Methionine metabolism, immune cells, Autoimmunity, Cancer, reprogramming
Received: 08 Sep 2025; Accepted: 25 Nov 2025.
Copyright: © 2025 Liu, Tang, Huang, Tang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jianian Tang
Yiwen Yang
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