REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
This article is part of the Research TopicThe Immunotherapy Revolution in the Management of Gynecological Cancers: From Preclinical Data to Clinical Results and Mechanisms of ImmunoresistanceView all 3 articles
CAR-NK Cell for Gynecological Cancers: Immune Microenvironment Remodeling and Immunotherapeutic Strategies
Provisionally accepted
- 1Putian University, Putian, China
- 2Fourth Affiliated Hospital of China Medical University, Shenyang, China
- 3Fourth Hospital of Xianyou, Putian, China
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Gynecological malignancies, including ovarian, cervical, and endometrial cancers, represent a substantial global health burden, contributing significantly to morbidity and mortality among women. Despite advancements in therapeutic strategies, outcomes for many patients remain suboptimal due to challenges such as late-stage detection and resistance to standard treatments. The advent of chimeric antigen receptor (CAR)-engineered natural killer (NK) cells has introduced a cutting-edge immunotherapy option. This review provides an in-depth exploration of the development of CAR-NK cells, emphasizing their sources, design methodologies, and applications in managing gynecological cancers. It also examines current obstacles and outlines innovative strategies to improve the effectiveness and safety of CAR-NK cell-based therapies. Furthermore, we discuss prospective advancements, highlighting the importance of ongoing research and technological innovation to unlock the full potential of CAR-NK cells in the fight against gynecological cancers.
Keywords: CAR-NK cells, gynecological cancers, Tumor immune microenvironment, immunemodulation, Immunotherapy
Received: 15 Sep 2025; Accepted: 21 Nov 2025.
Copyright: © 2025 Huang, Wang, Huang, Li and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mingyao Huang, huangmy@ptu.edu.cn
Linze Li, lzli@cmu.edu.cn
Tian Wang, il_lsl_phd@163.com
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