REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Beyond the blockade: Unmet needs in systemic targeted atopic dermatitis therapy
Provisionally accepted
- 1The First Affiliated Hospital of China Medical University, Shenyang, China
- 2Juntendo University Graduate School of Medicine, Toyko, Japan
- 3Juntendo University, Toyko, Japan
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Current atopic dermatitis treatments have been revolutionized by systemic targeted therapies that modulate inflammatory cytokine signaling pathways. While agents such as Janus kinase inhibitors and interleukin-4/interleukin-13 pathway inhibitors have shown significant efficacy, unmet needs persist. These needs include challenges in achieving stable disease control and remission, addressing nonresponders, managing potential side effects, and alleviating the ongoing struggle with pruritus. Future directions will focus on developing dual/multitarget drugs, creating longer-acting formulations, improving administration convenience, reducing dosing frequency, identifying novel therapeutic targets, and incorporating patient-reported outcomes in clinical assessments.
Keywords: atopic dermatitis, targeted therapies, biologics, JAK inhibitors, blockade
Received: 25 Sep 2025; Accepted: 11 Nov 2025.
Copyright: © 2025 Zhang, Peng, Wang, Niyonsaba and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Francois Niyonsaba, francois@juntendo.ac.jp
Xinghua Gao, xhgao@cmu.edu.cn
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