REVIEW article
Front. Immunol.
Sec. Inflammation
This article is part of the Research TopicRole of Extracellular Vesicles in InflammationView all 11 articles
Research progress on pyroptosis regulated by mesenchymal stem cell-derived exosomes
Provisionally accepted
- 1The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China, Gansu, China
- 2Department of Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, China, Gansu, China
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Pyroptosis is a newly discovered form of inflammatory programmed cell death, which is frequently involved in the occurrence and development of various diseases. The primary mechanism underlying pyroptosis is the formation of membrane pores mediated by activated pyroptosis-related proteins. The expression levels of these pyroptosis-related proteins serve as crucial biomarkers for assessing the degree of pyroptosis. Modulating pyroptosis can alleviate tissue and organ damage in diseases and promote tissue and organ repair. Therefore, regulating pyroptosis is considered a potential therapeutic strategy. In recent years, mesenchymal stem cell-derived exosomes (MSC-Exos) have emerged as a novel therapeutic tool for pyroptosis due to their carrier properties. MSC-Exos can mitigate tissue damage in various diseases by regulating pyroptosis, thus emerging as strong candidates for disease treatment. Owing to their multifunctionality, MSC-Exos exert different effects by mediating different pathways in the treatment of various diseases. This review summarizes the mechanisms of pyroptosis and the research progress on MSC-Exos-regulated pyroptosis, and outlines the existing challenges for the clinical translation of MSC-Exos. Collectively, MSC-Exos can not only precisely regulate the pyroptosis process but also provide new perspectives and approaches for future disease treatment. Therefore, MSC-Exos possess substantial potential for clinical translation.
Keywords: Mesenchymal Stem Cells, Exosomes, pyroptosis, Pathway, gasdermin
Received: 02 Oct 2025; Accepted: 19 Nov 2025.
Copyright: © 2025 yang, An, Xu, Li and Dou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhimin Dou, ldyy_douzhimin@lzu.edu.cn
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