MINI REVIEW article
Front. Immunol.
Sec. Immunological Memory
This article is part of the Research TopicDistinctive features of tissue-resident and circulating immune memory cellsView all articles
The role of immune cells-mediated memory in weight cycling, glucose disorders and insulin resistance
Provisionally accepted
- 1Qionglai Hospital of Traditional Chinese Medicine, Qionglai, China
- 2Sichuan Taikang Hospital, Chengdu, China
- 3Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
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Weight cycling (WC), defined as the repeated process of weight gain and loss, is one of the biggest challenges in the management of weight. It is estimated that the majority of individuals (60%) will regain their lost weight within a few years. There is a positive correlation between WC and the increased risk of metabolic diseases. Although multiple factors probably contribute to this variation, we hypothesize that immune cells-mediated immune memory plays a key role. In this review, we showed that immune memory is one of the core mechanisms of WC, glucose and insulin disorders. Immune cells, such as macrophages, CD4+ T cells, CD8+ T cells, Treg cells and CD7+ monocytes, were included. We also exhibited potential therapies to prevent WC targeting immune memory.
Keywords: immune memory, Weight cycling, Macrophages, T-cells, Insulin Resistance
Received: 09 Oct 2025; Accepted: 18 Nov 2025.
Copyright: © 2025 Chen, Zhou, Wang, Sun, Yin and Zi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Changyan Zi, 823623876@qq.com
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