EDITORIAL article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
This article is part of the Research TopicFerroptosis and regulation mechanism in the tumor immune microenvironment for tumor progression and treatmentView all 10 articles
Editorial: Ferroptosis and regulation mechanism in the tumor immune microenvironment for tumor progression and treatment
Provisionally accepted
- Jinan University, Guangzhou, China
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The field of ferroptosis research has burgeoned over the past decade, revealing profound implications for cancer biology and therapy. This special issue, "Ferroptosis and regulation mechanism in the tumor immune microenvironment for tumor progression and treatment," compiles pioneering work elucidating the multifaceted roles of ferroptosis across diverse malignancies. This topic that has rapidly evolved to reveal critical insights for cancer progression and therapy. This collection of nine articles underscores how ferroptosis-an iron-dependent form of cell death driven by lipid peroxidation-serves as a pivotal regulator in oncology, bridging molecular mechanisms with clinical applications. Collectively, these studies demonstrate that targeting ferroptosis can disrupt cancer resilience, yet they also emphasize the complexity of its interactions with immune cells and therapeutic agents, setting the stage for transformative advances in precision medicine. Innovations in nanomedicine and AI-driven delivery hold promise for optimizing combination therapies, ultimately transforming ferroptosis modulation into a cornerstone of oncology. This special issue collectively affirms that harnessing ferroptosis within the tumor immune microenvironment offers a paradigm for improving cancer treatment, with the potential to redefine therapeutic landscapes through continued interdisciplinary collaboration.
Keywords: ferroptosis, Tumor immune microenvironment, biomarker, tumor, Treatment
Received: 17 Nov 2025; Accepted: 25 Nov 2025.
Copyright: © 2025 Pan, wei, Wang and Pan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jinghua Pan
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