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Scope

Research in immunology has been very productive in understanding the processes by which the host responds to foreign antigens. In contrast, there has been less success in establishing the mechanisms by which the host ensures immunological tolerance to itself. It is becoming increasingly clear that the immune system is subject to numerous control mechanisms and checkpoints which all contribute to self-tolerance. It has also become clear that tolerance mechanisms are also exploited by the developing foetus, microbes and cancers, and to ensure minimal damage to tissues during immune responses.

The understanding of tolerance mechanisms will spawn a new generation of therapeutics to better control autoimmunity, allergy and transplant rejection, and to override tolerance to ensure optimal immune responses to microbial pathogens and cancers.

Immunological Tolerance and Regulation focuses on tolerance mechanisms, their exploitation and their avoidance, and aims to attract work in this rapidly evolving field of immunology. The Specialty section is one in a series of many that deal with “immunology” and aims at avoiding present day “editorial policies” that are not solely based on scientific content. 

Relevant to this topic are:

- Roles and mechanisms of different regulatory cells

- Microenvironments permissive for tolerance

- Avoidance of foetal rejection by the maternal immune system

- Ways in which tolerance mechanisms are bypassed and the consequences of this

- Checkpoint blockade to promote tolerance induction

- Desensitisation to allergens

- Tolerogenic mechanisms evoked by immunosuppressive drugs

- Impact of AIRE and FoxP3 genes

- Coinhibitory molecules in tolerance induction

- CD39, CD73 and adenosinergic pathways for tolerance

Facts

  • Short name

    Front. Immunol.

  • Abbreviation

    fimmu

  • Electronic ISSN

    1664-3224

  • PMCID

    All published articles receive a PMCID

  • Impact

    5.7 Impact Factor

    9.8 CiteScore

  • Indexed in

    PubMed, MEDLINE, PubMed Central (PMC), Scopus, Web of Science Science Citation Index Expanded (SCIE), Google Scholar, DOAJ, CrossRef, Chemical Abstracts Service (CAS), Embase, Semantic Scholar, Ulrich's Periodicals Directory, CLOCKSS, EBSCO, OpenAIRE, Zetoc

Submission

Immunological Tolerance and Regulation welcomes submissions of the following article types: Brief Research Report, Case Report, Classification, Clinical Trial, Correction, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Systematic Review, Technology and Code.

All manuscripts must be submitted directly to the section Immunological Tolerance and Regulation, where they are peer-reviewed by the Associate and Review Editors of the specialty section.

Open access statement

Open access logo

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That is why Frontiers provides online free and open access to all of its research publications. For more information on open access click here.

Open access funder and institutional mandates

Frontiers is fully compliant with open access mandates, by publishing its articles under the Creative Commons Attribution licence (CC-BY). Funder mandates such as those by the Wellcome Trust (UK), National Institutes of Health (USA) and the Australian Research Council (Australia) are fully compatible with publishing in Frontiers. Authors retain copyright of their work and can deposit their publication in any repository. The work can be freely shared and adapted provided that appropriate credit is given and any changes specified.

Quality

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Frontiers uses the single anonymized peer review model, where the reviewer identity is not made visible to the author, while the author identity is visible to the reviewer, and reviewer and the authors’ identities are visible to the decision-making editor. Reviewers interact with the handling editor and the authors. Editor and reviewer names and affiliations are published on all Frontiers articles.

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Frontiers has a number of procedures in place to support and ensure the quality of the research articles that are published:

  • 2023

    • Editorial Board Quality

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      • Frontiers algorithms are constantly fine-tuned to better match Review Editors with manuscripts, and additional checks are being coded into the platform, for example regarding conflicts of interest.

      • Should it become clear that a particular reviewer has a conflict of interest or is unable to perform the peer-review timely and adequately, he or she shall be replaced with an alternative reviewer by the Associate Editor or the Chief Editor, who will be alerted and has full control to intervene into the peer-review at any time.

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    • Interactive Review Stage Quality

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      • Reviewers can recommend rejection at this stage if their requests to correct objective errors are not being met by the authors or if they deem the article overall of insufficient quality.

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