Frontiers in Immunology | Systems Immunology

Original Research

Published on 08 Mar 2024

Structure-guided engineering and molecular simulations to design a potent monoclonal antibody to target aP2 antigen for adaptive immune response instigation against type 2 diabetes

in Systems Immunology

Abbas Khan
Muhammad Ammar Zahid
Anwar Mohammad
Abdelali Agouni

Frontiers in Immunology

doi 10.3389/fimmu.2024.1357342

3,445 views
3 citations

Original Research

Published on 06 Mar 2024

Exploring potential biomarkers and therapeutic targets in inflammatory bowel disease: insights from a mega-analysis approach

in Systems Immunology

Edia Stemmer
Tamar Zahavi
Maoz Kellerman
Liat Anabel Sinberger
Guy Shrem
Mali Salmon‐Divon

Frontiers in Immunology

doi 10.3389/fimmu.2024.1353402

5,454 views
5 citations

Review

Published on 01 Mar 2024

Interferon lambda in respiratory viral infection: immunomodulatory functions and antiviral effects in epithelium

in Systems Immunology

Yong-Guang Liu
Su-Wei Jin
Shan-Shan Zhang
Tian-Ji Xia
Yong-Hong Liao
Rui-Le Pan
Ming-Zhu Yan
Qi Chang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1338096

7,745 views
6 citations

Original Research

Published on 28 Feb 2024

Investigating the ability of deep learning-based structure prediction to extrapolate and/or enrich the set of antibody CDR canonical forms

in Systems Immunology

Alexander Greenshields-Watson
Brennan Abanades
Charlotte M. Deane

Frontiers in Immunology

doi 10.3389/fimmu.2024.1352703

4,288 views
6 citations

Methods

Published on 26 Feb 2024

Utilizing murine dendritic cell line DC2.4 to evaluate the immunogenicity of subunit vaccines in vitro

in Systems Immunology

Lantian Lu
Wei Yang Kong
Jiahui Zhang
Farrhana Firdaus
James W. Wells
Rachel J. Stephenson
Istvan Toth
Mariusz Skwarczynski
Jazmina L. Gonzalez Cruz

Frontiers in Immunology

doi 10.3389/fimmu.2024.1298721

13,457 views
7 citations

Original Research

Published on 26 Feb 2024

An integrative mechanistic model of thymocyte dynamics

in Systems Immunology

Victoria Kulesh
Kirill Peskov
Gabriel Helmlinger
Gennady Bocharov

Frontiers in Immunology

doi 10.3389/fimmu.2024.1321309

2,669 views
3 citations

Original Research

Published on 23 Feb 2024

CD8+ T and NK cells characterized by upregulation of NPEPPS and ABHD17A are associated with the co-occurrence of type 2 diabetes and coronary artery disease

in Systems Immunology

Chenyu Dai
Damu Wang
Qianqian Tao
Ziyi Li
Peng Zhai
Yingying Wang
Mei Hou
Simin Cheng
Wei Qi
Longyi Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2024.1267963

3,938 views
4 citations

Original Research

Published on 22 Feb 2024

Comprehensive bioinformatics analysis and systems biology approaches to identify the interplay between COVID-19 and pericarditis

in Systems Immunology

Daisong Li
Ruolan Chen
Chao Huang
Guoliang Zhang
Zhaoqing Li
Xiaojian Xu
Banghui Wang
Bing Li
Xian-Ming Chu

Frontiers in Immunology

doi 10.3389/fimmu.2024.1264856

2,930 views
2 citations

Original Research

Published on 21 Feb 2024

Unveiling macrophage diversity in myocardial ischemia-reperfusion injury: identification of a distinct lipid-associated macrophage subset

in Systems Immunology

Ying Jiang
Wenpeng Yu
Tie Hu
Hanzhi Peng
Fajia Hu
Yong Yuan
Xufeng Liu
Songqing Lai
Jianliang Zhou
Xiao Dong

Frontiers in Immunology

doi 10.3389/fimmu.2024.1335333

8,939 views
13 citations

Hypothesis and Theory

Published on 21 Feb 2024

The integrated bioinformatic analysis identifies immune microenvironment-related potential biomarkers for patients with gestational diabetes mellitus

in Systems Immunology

Jie-ling Chen
Hui-fang Dai
Xin-chen Kan
Jie Wu
Hong-Wu Chen

Frontiers in Immunology

doi 10.3389/fimmu.2024.1296855

2,332 views
2 citations

Original Research

Published on 16 Feb 2024

Systems and computational analysis of gene expression datasets reveals GRB-2 suppression as an acute immunomodulatory response against enteric infections in endemic settings

in Systems Immunology

Akshayata Naidu
Sajitha Lulu S.

Frontiers in Immunology

doi 10.3389/fimmu.2024.1285785

3,181 views
3 citations

Original Research

Published on 15 Feb 2024

Urinary miR-185-5p is a biomarker of renal tubulointerstitial fibrosis in IgA nephropathy

in Systems Immunology

Zhi-Yu Duan
Ru Bu
Shuang Liang
Xi-Zhao Chen
Chun Zhang
Qiu-Yue Zhang
Ji-Jun Li
Xiang-Mei Chen
Guang-Yan Cai

Frontiers in Immunology

doi 10.3389/fimmu.2024.1326026

3,673 views
10 citations

Original Research

Published on 13 Feb 2024

Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches

in Systems Immunology

Anna Niarakis
Marek Ostaszewski
Alexander Mazein
Inna Kuperstein
Martina Kutmon
Marc E. Gillespie
Akira Funahashi
Marcio Luis Acencio
Ahmed Hemedan
Michael Aichem

Frontiers in Immunology

doi 10.3389/fimmu.2023.1282859

11,876 views
9 citations

Technology and Code

Published on 08 Feb 2024

DiscoTope-3.0: improved B-cell epitope prediction using inverse folding latent representations

in Systems Immunology

Magnus Haraldson Høie
Frederik Steensgaard Gade
Julie Maria Johansen
Charlotte Würtzen
Ole Winther
Morten Nielsen
Paolo Marcatili

Frontiers in Immunology

doi 10.3389/fimmu.2024.1322712

11,924 views
50 citations

Original Research

Published on 02 Feb 2024

MIHIC: a multiplex IHC histopathological image classification dataset for lung cancer immune microenvironment quantification

in Systems Immunology

Ranran Wang
Yusong Qiu
Tong Wang
Mingkang Wang
Shan Jin
Fengyu Cong
Yong Zhang
Hongming Xu

Frontiers in Immunology

doi 10.3389/fimmu.2024.1334348

6,355 views
6 citations

Original Research

Published on 01 Feb 2024

Quantitative multiplex immunohistochemistry reveals inter-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma

in Systems Immunology

Julia Femel
Cameron Hill
Irineu Illa Bochaca
Jamie L. Booth
Tina G. Asnaashari
Maria M. Steele
Ata S. Moshiri
Hyungrok Do
Judy Zhong
Iman Osman

Frontiers in Immunology

doi 10.3389/fimmu.2024.1328602

5,499 views
2 citations