Frontiers in Immunology | Systems Immunology

Original Research

Published on 25 Nov 2022

Identification of two robust subclasses of sepsis with both prognostic and therapeutic values based on machine learning analysis

in Systems Immunology

Wei Zhou
Chunyu Zhang
Zhongwei Zhuang
Jing Zhang
Chunlong Zhong

Frontiers in Immunology

doi 10.3389/fimmu.2022.1040286

4,916 views
6 citations

Original Research

Published on 21 Nov 2022

Preparing for the next pandemic: Simulation-based deep reinforcement learning to discover and test multimodal control of systemic inflammation using repurposed immunomodulatory agents

in Systems Immunology

Chase Cockrell
Dale Larie
Gary An

Frontiers in Immunology

doi 10.3389/fimmu.2022.995395

3,505 views
6 citations

Methods

Published on 17 Nov 2022

Integrated machine learning approaches for flow cytometric quantification of myeloid-derived suppressor cells in acute sepsis

in Systems Immunology

Anthony S. Bonavia
Abigail Samuelsen
Joshua Luthy
E. Scott Halstead

Frontiers in Immunology

doi 10.3389/fimmu.2022.1007016

3,671 views
1 citation

Perspective

Published on 07 Nov 2022

Single-cell profiling to transform immunotherapy usage and target discovery in immune-mediated inflammatory diseases

in Systems Immunology

Nicolas Chapelle
Aurelie Fantou
Thomas Marron
Ephraim Kenigsberg
Miriam Merad
Jerome C. Martin

Frontiers in Immunology

doi 10.3389/fimmu.2022.1006944

3,021 views
1 citation

Original Research

Published on 04 Nov 2022

Identifying hub genes of calcific aortic valve disease and revealing the immune infiltration landscape based on multiple WGCNA and single-cell sequence analysis

in Systems Immunology

Kan Wang
Qiang Zheng
Xing Liu
BingChuan Geng
NianGuo Dong
JiaWei Shi

Frontiers in Immunology

doi 10.3389/fimmu.2022.1035285

18,101 views
9 citations

Original Research

Published on 03 Nov 2022

Moving the needle: Employing deep reinforcement learning to push the boundaries of coarse-grained vaccine models

in Systems Immunology

Jonathan G. Faris
Daniel Orbidan
Charles Wells
Brenden K. Petersen
Kayla G. Sprenger

Frontiers in Immunology

doi 10.3389/fimmu.2022.1029167

3,590 views
7 citations

Original Research

Published on 03 Nov 2022

Exploration of blood−derived coding and non-coding RNA diagnostic immunological panels for COVID-19 through a co-expressed-based machine learning procedure

in Systems Immunology

Mohadeseh Zarei Ghobadi
Rahman Emamzadeh
Majid Teymoori-Rad
Elaheh Afsaneh

Frontiers in Immunology

doi 10.3389/fimmu.2022.1001070

3,213 views
17 citations

Original Research

Published on 31 Oct 2022

COL11A1 as an novel biomarker for breast cancer with machine learning and immunohistochemistry validation

in Systems Immunology

Wenjie Shi
Zhilin Chen
Hui Liu
Chen Miao
Ruifa Feng
Guilin Wang
Guoping Chen
Zhitong Chen
Pingming Fan
Weiyi Pang

Frontiers in Immunology

doi 10.3389/fimmu.2022.937125

6,757 views
27 citations

Review

Published on 31 Oct 2022

A review of spatial profiling technologies for characterizing the tumor microenvironment in immuno-oncology

in Systems Immunology

Bian Hu
Muhammad Sajid
Rong Lv
Lianxin Liu
Cheng Sun

Frontiers in Immunology

doi 10.3389/fimmu.2022.996721

13,048 views
40 citations

Methods

Published on 27 Oct 2022

pyTCR: A comprehensive and scalable solution for TCR-Seq data analysis to facilitate reproducibility and rigor of immunogenomics research

in Systems Immunology

Kerui Peng
Jaden Moore
Mohammad Vahed
Jaqueline Brito
Guoyun Kao
Amanda M. Burkhardt
Houda Alachkar
Serghei Mangul

Frontiers in Immunology

doi 10.3389/fimmu.2022.954078

5,103 views
3 citations

Original Research

Published on 26 Oct 2022

A network view of human immune system and virus-human interaction

in Systems Immunology

Kang Tang
Jing Tang
Jinfeng Zeng
Wei Shen
Min Zou
Chi Zhang
Qianru Sun
Xiaoyan Ye
Chunwei Li
Caijun Sun

Frontiers in Immunology

doi 10.3389/fimmu.2022.997851

3,813 views
3 citations

Original Research

Published on 21 Oct 2022

Hallucinating structure-conditioned antibody libraries for target-specific binders

in Systems Immunology

Sai Pooja Mahajan
Jeffrey A. Ruffolo
Rahel Frick
Jeffrey J. Gray

Frontiers in Immunology

doi 10.3389/fimmu.2022.999034

7,260 views
17 citations

Original Research

Published on 20 Oct 2022

Immune-associated pivotal biomarkers identification and competing endogenous RNA network construction in post-operative atrial fibrillation by comprehensive bioinformatics and machine learning strategies

in Systems Immunology

Yufei Zhou
Qianyun Wu
Gehui Ni
Yulu Hong
Shengjue Xiao
Chunjiang Liu
Zongliang Yu

Frontiers in Immunology

doi 10.3389/fimmu.2022.974935

5,474 views
8 citations

Original Research

Published on 20 Oct 2022

Exploration of shared features of B cell receptor and T cell receptor repertoires reveals distinct clonotype clusters

in Systems Immunology

Sang Bin Hong
Yong-Won Shin
Ja Bin Hong
Sang Kun Lee
Buhm Han

Frontiers in Immunology

doi 10.3389/fimmu.2022.1006136

4,331 views
2 citations

Original Research

Published on 17 Oct 2022

Biological signatures and prediction of an immunosuppressive status—persistent critical illness—among orthopedic trauma patients using machine learning techniques

in Systems Immunology

Mingxing Lei
Zhencan Han
Shengjie Wang
Chunxue Guo
Xianlong Zhang
Ya Song
Feng Lin
Tianlong Huang

Frontiers in Immunology

doi 10.3389/fimmu.2022.979877

4,938 views
21 citations

Original Research

Published on 17 Oct 2022

Spatial transcriptomics of the lacrimal gland features macrophage activity and epithelium metabolism as key alterations during chronic inflammation

in Systems Immunology

Olivier Mauduit
Vanessa Delcroix
Takeshi Umazume
Cintia S. de Paiva
Darlene A. Dartt
Helen P. Makarenkova

Frontiers in Immunology

doi 10.3389/fimmu.2022.1011125

8,099 views
16 citations