Frontiers in Immunology | T Cell Biology

Original Research

Published on 03 Mar 2025

A backbone-based flow cytometry approach to decipher regulatory T cell trajectories in the human thymus

in T Cell Biology

Beatriz Moleirinho
Margarida Paulo-Pedro
Nicole C. Martins
Emily Jelagat
Eller Conti
Tiago R. Velho
Miguel Abecasis
Rui Anjos
Afonso R. M. Almeida
Ana E. Sousa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1553535

2,520 views

Correction

Published on 27 Feb 2025

Corrigendum: State of play in the molecular presentation and recognition of anti-tumor lipid-based analogues

in T Cell Biology

T. Praveena
Jérôme Le Nours

Frontiers in Immunology

doi 10.3389/fimmu.2025.1574591

542 views

Original Research

Published on 26 Feb 2025

Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biomarkers

in T Cell Biology

Vasileios Kyttaris
Daniel J. Wallace
Arezou Khosroshahi
Andrew Concoff
Nicole Wilson
Chau Ching Liu
Susan Manzi
Joseph Ahearn
Sepehr Taghavi
Touba Warsi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1518208

4,817 views

Review

Published on 26 Feb 2025

The clinical significance of T-cell regulation in hypertension treatment

in T Cell Biology

Miaoxin Fu
Mingzhu Lv
Jinyue Guo
Aihua Mei
Hang Qian
Handong Yang
Wenwen Wu
Zhixin Liu
Jixin Zhong
Ying Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550206

2,071 views
1 citation

Brief Research Report

Published on 25 Feb 2025

Co-expression of B7-H3 and LAG3 represents cytotoxicity of CD4+ T cells in humans

in T Cell Biology

Yumi Tamura
Shun Ohki
Haruna Nagai
Rin Yoshizato
Shizuki Nishi
Yuqi Jin
Yasuo Kitajima
Yun Guo
Tatsuo Ichinohe
Satoshi Okada

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560383

2,240 views

Review

Published on 19 Feb 2025

Neural regulation of the thymus: past, current, and future perspectives

in T Cell Biology

Randall S. Carpenter
Maria K. Lagou
George S. Karagiannis
Maria Maryanovich

Frontiers in Immunology

doi 10.3389/fimmu.2025.1552979

2,675 views
1 citation

Editorial

Published on 18 Feb 2025

Editorial: Current insights in cancer metabolism and T cell based tumor immunity

in T Cell Biology

Takashi MaruYama
Takashi Tanikawa
Jian Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1566491

793 views

Original Research

Published on 18 Feb 2025

Recognition of MR1-antigen complexes by TCR Vγ9Vδ2

in T Cell Biology

José Pedro Loureiro
Alessandro Vacchini
Giuliano Berloffa
Jan Devan
Verena Schaefer
Vladimir Nosi
Rodrigo Colombo
Aisha Beshirova
Giulia Montanelli
Benedikt Meyer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1519128

2,160 views

Original Research

Published on 17 Feb 2025

Use of a universal targeting CAR T cell to simultaneously kill cancer cells and cancer-associated fibroblasts

in T Cell Biology

Bo Huang
Suilan Zheng
Kasireddy Sudarshan
Ramesh Mukkamala
Madduri Srinivasarao
Tushar Sardesai
Xiaofei Yang
Haiyan Chu
Philip S. Low

Frontiers in Immunology

doi 10.3389/fimmu.2025.1539265

3,238 views
2 citations

Brief Research Report

Published on 17 Feb 2025

A large-scale database of T-cell receptor beta sequences and binding associations from natural and synthetic exposure to SARS-CoV-2

in T Cell Biology

Sean Nolan
Marissa Vignali
Mark Klinger
Jennifer N. Dines
Ian M. Kaplan
Emily Svejnoha
Tracy Craft
Katie Boland
Mitchell W. Pesesky
Rachel M. Gittelman

Frontiers in Immunology

doi 10.3389/fimmu.2025.1488851

2,114 views
12 citations

Original Research

Published on 13 Feb 2025

Modulation of double-negative T cells by Huang-Lian-Jie-Du Decoction attenuates neuroinflammation in ischemic stroke: insights from single-cell transcriptomics

in T Cell Biology

Kai Wang
Zijin Sun
Qi Shao
Zhaoyi Wang
Haojia Zhang
Yuanhua Li
Jingmei Ming
Wenjing Zhang
Tieshan Wang
Yan Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1537277

1,913 views

Original Research

Published on 11 Feb 2025

Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer

in T Cell Biology

Lulu Zhang
Xiyuan Guo
Xiaoke Sun
Jue Liao
Qin Liu
Yingchun Ye
Zhihui Yang
Ratchada Cressey
Qing He
Qing Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1486329

2,821 views

Original Research

Published on 07 Feb 2025

Commensal bacteria education history calibrates the naivety and activation threshold of adaptive antiviral immune system

in T Cell Biology

Baohua Li
Zhou Sha
Li Mou
Feng Zhang
Lifeng Jia
Yan Zhu
Yan Guo
Guohong Deng
Haibo Wu
Hong Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1519023

1,569 views

Original Research

Published on 07 Feb 2025

Effects of neutrophil granule proteins on sepsis-associated lymphopenia and their relationship with CD4+ T-cell pyroptosis

in T Cell Biology

Jia-yu Mao
Ya-wen Xie
Xian-li Lei
Jia-hui Zhang
Wei Cheng
Na Cui

Frontiers in Immunology

doi 10.3389/fimmu.2025.1507800

1,313 views

Original Research

Published on 06 Feb 2025

Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy

in T Cell Biology

Jianyao Zeng
Yan Sun
Yuan Fang
Xiaodie Wang
Qian Huang
Pingjing Zhang
Meiqi Shao
Pei Wang
Jingbo Cheng
Meng Di

Frontiers in Immunology

doi 10.3389/fimmu.2025.1541653

1,848 views

Review

Published on 06 Feb 2025

A comprehensive review of the roles of T-cell immunity in preeclampsia

in T Cell Biology

Xu Peng
Ibeh Chinwe Oluchi-Amaka
Joanne Kwak-Kim
Xiuhua Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1476123

2,232 views
2 citations