ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1464573
This article is part of the Research TopicInnovation in Tackling the Global Challenge of Eradicating Antibiotic-Resistant MicroorganismsView all 14 articles
Distribution and analysis of the resistance profiles of bacteria isolated from blood cultures in the intensive care unit
Provisionally accepted
- 1The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- 2Quanzhou First Hospital, Fujian Medical University, Quanzhou, Fujian Province, China
- 3Key Laboratory of Screening and Control of Infectious Diseases (Quanzhou Medical College), Fujian Provincial University, Quanzhou, Fujian Province, China
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Purpose: To investigate the distribution characteristics and drug resistance of pathogenic bacteria in bloodstream infections, providing a basis for rational clinical treatment.Patients and Methods: Retrospective analysis of 1,282 pathogenic strains isolated from blood cultures in the intensive care unit (ICU) of the Second Affiliated Hospital of Xi'an Jiaotong University from January 1, 2019, to December 31, 2022.Results: Gram-positive bacteria (52.0%) slightly predominated over gram-negative bacteria (48.0%). The top three gram-positive bacteria were Coagulase-negative Staphylococcus (28.0%), Enterococcus faecium (7.4%) and Staphylococcus aureus(6.6%). Staphylococci exhibited a high resistance rate to penicillin, oxacillin, and erythromycin; no strains resistant to vancomycin or linezolid were found. Among the Enterococci, Enterococcus faecium had a high resistance rate to penicillin, ampicillin, and erythromycin. Two strains of Enterococcus faecalis were resistant to linezolid, but none to vancomycin. The top three gram-negative bacteria were Escherichia coli (14.7%), Klebsiella pneumoniae (14.0%), and Acinetobacter baumannii (4.8%). The resistance rate of Escherichia coli to carbapenems increased from 0.0% to 2.3%. Acinetobacter baumannii reached 100% carbapenem resistance (up from 75.0%), while Klebsiella pneumoniae demonstrated 21.1-80.4% resistance to various carbapenems. Conclusions: The isolation rate of gram-positive bacteria in patients with bloodstream infection in the ICU of the Second Affiliated Hospital of Xi'an Jiaotong University was slightly higher than that of gram-negative bacteria. The alarming carbapenem resistance among gram-negative pathogens and emerging linezolid resistance in Enterococci demand urgent clinical interventions, including enhanced surveillance, antimicrobial stewardship, and novel therapeutic strategies
Keywords: Blood culture, Drug Resistance, pathogens, Intensive Care Unit, Antimicrobial susceptibility test
Received: 14 Jul 2024; Accepted: 19 Jun 2025.
Copyright: © 2025 Liu, Cai, Lei, Zhang, Yin, Zhang, Yu and Geng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xueping Yu, Quanzhou First Hospital, Fujian Medical University, Quanzhou, 362000, Fujian Province, China
Yan Geng, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
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