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SYSTEMATIC REVIEW article

Front. Microbiol., 27 May 2025

Sec. Antimicrobials, Resistance and Chemotherapy

Volume 16 - 2025 | https://doi.org/10.3389/fmicb.2025.1542472

Quantifying antimicrobial resistance in food-producing animals in North America

  • Département d'informatique, Université du Québec á Montréal, Montreal, QC, Canada

The global misuse of antimicrobial medication has further exacerbated the problem of antimicrobial resistance (AMR), enriching the pool of genetic mechanisms previously adopted by bacteria to evade antimicrobial drugs. AMR can be either intrinsic or acquired. It can be acquired either by selective genetic modification or by horizontal gene transfer that allows microorganisms to incorporate novel genes from other organisms or environments into their genomes. To avoid an eventual antimicrobial mistreatment, the use of antimicrobials in farm animal has been recently reconsidered in many countries. We present a systematic review of the literature discussing the cases of AMR and the related restrictions applied in North American countries (including Canada, Mexico, and the USA). The Google Scholar, PubMed, Embase, Web of Science, and Cochrane databases were searched to find plausible information on antimicrobial use and resistance in food-producing animals, covering the time period from 2015 to 2024. A total of 580 articles addressing the issue of antibiotic resistance in food-producing animals in North America met our inclusion criteria. Different AMR rates, depending on the bacterium being observed, the antibiotic class being used, and the farm animal being considered, have been identified. We determined that the highest average AMR rates have been observed for pigs (60.63% on average), the medium for cattle (48.94% on average), and the lowest for poultry (28.43% on average). We also found that Cephalosporines, Penicillins, and Tetracyclines are the antibiotic classes with the highest average AMR rates (65.86%, 61.32%, and 58.82%, respectively), whereas the use of Sulfonamides and Quinolones leads to the lowest average AMR (21.59% and 28.07%, respectively). Moreover, our analysis of antibiotic-resistant bacteria shows that Streptococcus suis (S. suis) and S. auerus provide the highest average AMR rates (71.81% and 69.48%, respectively), whereas Campylobacter spp. provides the lowest one (29.75%). The highest average AMR percentage, 57.46%, was observed in Mexico, followed by Canada at 45.22%, and the USA at 42.25%, which is most probably due to the presence of various AMR control strategies, such as stewardship programs and AMR surveillance bodies, existing in Canada and the USA. Our review highlights the need for better strategies and regulations to control the spread of AMR in North America.

1 Introduction

The increasing demand for meat around the globe has led to a significant rise in livestock breeding (Graham and Nachman, 2010; Chriki and Hocquette, 2020). Livestock are usually fed with drinkable water and food mixed with antimicrobial drugs (Sapkota et al., 2007; Brown et al., 2019). The availability and the use of antimicrobials have transmuted the practice of veterinary medicine (Lees et al., 2021; Schwarz et al., 2017; Drouillard, 2018; Prescott, 2017; Paulson et al., 2015). Several fatal animal infections have now become treatable as the antimicrobial use (AMU) has led to significant advances in global health, animal health, food safety, and food security. However, the abuse and misuse of antimicrobials have contributed significantly to the emergence and expansion of antimicrobial resistance (AMR), posing a serious threat to human and animal health as well as to the global ecosystem (Kahn, 2017; Mehrotra M, 2017; Thakur and Gray, 2019; McCubbin et al., 2021; Otto et al., 2022; Cobo-Angel and Gohar, 2022; Xu et al., 2022). Approximately, 700,000 people around the globe die every year because of antimicrobial misuse. It has been estimated that this number will increase to 10 million people by 2050 (O'Neill, 2016). According to Nathan (2020), the development of new antibiotics is declining, but the global antimicrobial consumption in food animals is accelerating. Several studies have shown that AMR of animal origin can be transmitted to humans through food production (Ribeiro et al., 2024; Martak et al., 2024) as well as to the environment (Graham et al., 2009; Fujita et al., 2022). Evidence linking AMR between animals and humans is particularly strong for common foodborne pathogens resistant to Quinolones, such as Campylobacter spp. and Salmonella spp. (Engberg et al., 2001). Nowadays, antimicrobial resistance became a major public health challenge, which requires deeper study and immediate action to combat it (World Health Organization, 2012). Van Boeckel et al. (2015) have discussed the relationships between AMU and AMR in farmed animals in a systematic review covering the period from 2000 to 2018. Following multiple international calls for urgent action, the North American countries (Canada, Mexico, and the USA) reacted to protect their population by introducing several antibiotic restriction policies discussed below.

The observation of antimicrobial use in farm animals in Canada started with the report of Health Canada in 2002 (Uses of Microbalances in Food Animals in Canada: Impact on Resistance and Human Health).1 The Canadian Integrated Program for Antimicrobial Resistance (CIPARS) was launched to better understand the antimicrobial resistance in livestock and its impact on human health. Since 2005, CIPARS has been publishing an annual report presenting the current situation in the field (Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS)).2 In 2014, Health Canada announced some important actions, including the strict restriction and veterinary prescription of all antimicrobial drugs. Several actors have been engaged in these actions, including the Canadian Food Inspection Agency and Agriculture and Agri-Food Canada (Antimicrobial Resistance and Use in Canada: A Federal Framework for Action).3 In 2017, the Canadian government started working with provincial partners to monitor antimicrobial use. Since 2018, the importation and self-manufacturing of antimicrobials have been banned in Canada. These actions were supported by the Canadian Animal Health Institute.4 The exact restriction policy being applied in each case differs with respect to the Canadian province, which takes full responsibility for regulatory actions. For example, in Ontario, the College of Veterinarians of Ontario, in collaboration with veterinarians and farmers, has identified the standardization of laboratory reporting as a major AMR preventing priority (College of Veterinarians of Ontario, 2017). Other associations and voluntary organizations, as for example the Canadian Cattlemen's Association, have been also involved in the establishment of the AMR restriction policies. For instance, the Canadian chicken farms have been actively involved in this work due to the spread of ceftiofur-resistant Salmonella Heidelberg pathogen (Dutil et al., 2010).

A survey conducted between 2013 and 2015 in the United States showed that 88% of veterinarians are ignorant of any veterinary professional guidelines related to AMU and AMR, thus raising the government's concern about this issue (International Society for Companion Animal Infectious Diseases).5 The American Food and Drug Administration (FDA) Center for Veterinary Medicine proposed some suggestions specifying the duration of AMU in food and water under veterinary oversight and providing a comprehensive AMU data collection for companion animals, thus increasing AMU data sharing. We can mention that California was the first USA state that required the use of medically important antimicrobials (Antimicrobial Use and Stewardship (Aus) Program Report to the Legislature, California, USA, 2019). Moreover, the American Veterinary Medical Association (AVMA) created an antimicrobial committee made up of the American Animal Hospital Association (AAHA) and the American Association of Swine Veterinarians (AASV) (Antimicrobial Stewardship in Companion Animal Practice, 2015). AVMA's activities involve creating and sharing guidelines as well as promoting stewardship for companion animal practice. Recently, a national veterinary regulation action plan for 2020–2025, intended to combat antibiotic-resistant bacteria and restrict the antimicrobial use in the United States, has been adopted by the Presidential Advisory Council (National Action Plan for Combating Antibiotic-Resistant Bacteria).6

In Mexico, a national initiative for the containment of antimicrobial resistance was endorsed by major medical, veterinary, and public health institutions to better control the situation with antimicrobial use in food-producing animals (Zaidi et al., 2015). This initiative consists in establishing of effective surveillance systems. Furthermore, the Mexican Ministry of Health issued a decree enforcing some regulations that require medical prescriptions.

Several studies have been conducted regarding the global issue of antimicrobial resistance in farm animals, and different solutions have been proposed depending on national strategies and regulations maintained by each country. In this context, we will perform a meta-analysis to identify the main AMR trends typical for the three largest North American countries Canada, Mexico, and the USA.

2 Methods

2.1 Search strategy and selection criteria

Google Scholar, PubMed, EMBASE, MEDLINE, Web of Science Core Collection (Science Citation Index and Emerging Sources Citation Index), and Cochrane Library have been searched to gather information on antimicrobial resistance on North American farms. Articles written in English and covering the time period from 2015 to 2024 have been selected for our review study. Search terms for our investigation included the following keywords: “antibiotic(s)”, “antimicrobial(s)”, “food animals”, “food-producing animal”, “farm animal”, “environment”, “bacteria”, “virus”, “water”, “soil”, “manure heaps”, “ponds”, “barns”, “calf hutches”, “straw and other bedding”, “feed and feed trough”, “water and water troughs”, “farm equipment”, “ground and pasture”, “watercourses, “USA”, “Canada”, “Mexico”, “cattle”, “poultry”, and “pig(s)”. The reference list of all plausible articles (published between 2015 and 2024) has been established, and the most cited articles have been considered first. In some cases, the authors, including students, professors, veterinarians, and experts in epidemiology have been contacted for some clarification about the results. The retained papers focused on the three types of food-producing animals: cattle, poultry, and pigs. As our study aims at quantifying and understanding the impact of AMR in North America, our search was limited to the studies concerning the three largest American countries: Canada, Mexico, and the USA. No search restrictions have been applied to bacterial species under study. Figure 1 shows the flowchart presenting our main search selection criteria.

Figure 1
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Figure 1. Flowchart illustrating our search selection criteria for inclusion of relevant AMR-related studies.

2.2 Data analysis

Different relevant meta-data were extracted from each of the selected papers, including: Country, farm animal(s), sample type (e.g., meat or fecal matter), sampling environment (e.g., river, soil, or feedlot), living animal specimen type (e.g., swab, nasopharynges lungs and joints, blood, vaginal, paw, tissue, or saliva) or carcass specimen type (e.g., tissue or corpse). Meta-analysis has been conducted for food-producing animals only, and not for humans or the environment. Regarding food-producing animals, we limited our investigation to cattle (cow and bovine), poultry (chicken and turkey), and pigs. Regarding antimicrobials, the 11 following groups of antibiotic classes were considered: Penicillins, Tetracyclines, Sulphonamides, Macrolides, Pleuromutilins, Lincosamides, Aminoglycosides, Amphenicols, Chloramphenicol, Cephalosporins, and Quinolones.

2.3 Main pathways of antimicrobial resistance

Minimizing the transmission of antibiotic-resistant bacteria remain a very relevant and challenging issue. Unfortunately, no universal solution has been proposed to solve it. Figure 2 presents the main pathways of antimicrobial resistance spread between animals, humans, and the environment. In many occasions, the transmission is direct, but some intermediate, often unknown, zoonotic hosts may also be involved in the chain of transmission. Direct contacts with animals can accelerate the spread of resistant bacteria as it was for example the case of the methicillin-resistant Staphylococcus aureus (S. aureus) bacterium isolated from the US swine population (Hau et al., 2017). Farmers, their families, and veterinarians are the most vulnerable people to be infected by antibiotic-resistant bacteria. These bacteria can be transferred to the food products at the stage of livestock slaughter as well. Obviously, humans can be also contaminated by bacteria through the meat, if it is not cooked properly (Heiman et al., 2015; Christidis et al., 2020).

Figure 2
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Figure 2. Main pathways of antimicrobial resistance spread between food-producing animals, humans, and the environment.

Bacteria that come from animals, which can be their healthy or asymptomatic carriers, are generally pathogenic for humans, increasing the human mortality rate (Smith et al., 2020; Anomaly, 2015; Dalton et al., 2020; Rodríguez-Medina et al., 2019). Moreover, unwashed fruits or vegetables can be another path of bacterial contamination (Rahman et al., 2021; Dharmarha et al., 2019; Godínez-Oviedo et al., 2023). Vegetables can be easily contaminated through human/animal feces or wastewater (Huang et al., 2015; Huijbers et al., 2015; Ibekwe et al., 2023). The environment often plays a connection role between different farm compartments, and especially between animals compost, soil, water, sediments, and sewage. Generally, antibiotics are used for therapeutic purposes and livestock receive antibiotics in their feed for disease prevention. According to many authors, the non-therapeutic use occurs later in animals, when they reach the feedlot (Veterinary Feed Directive (VFD)).7 Manure is the predominant propagation pathway of AMR in farms (Dungan et al., 2018). Table 1 presents some typical examples of antibiotic resistance genes (ARGs) detected on North American farm animals, the environments, and humans. We can observe that phenotypic and molecular characterization sequencing methods, such as Polymerase Chain Reaction (PCR) and Whole Genome Sequencing (WGS), have been widely used to identify ARGs. Such a variety of studies and methods being used reveal that North American countries are very concerned with AMR detected in livestock and search for effective solutions to address this important challenge. However, the sampling and design variation makes the comparison between the resulting data fairly complicated. The global expansion of the pharmaceutical industry, driven by the rising demand for antibiotics, plays a significant role in environmental challenges. Pharmaceutical wastewater contains high concentrations of antibiotics and antibiotic resistance genes, making these areas hotspots for environmental pollution and the spread of AMR. Poor treatment and improper discharge of such wastewater into the environment result in significant antibiotic contamination, whereas its prolonged presence in the environment can alter bacterial genomes, contributing to the rise and spread of AMR (Kotwani et al., 2021).

Table 1
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Table 1. Typical examples of antimicrobial resistance genes (ARG) detected in animals, the environment, and humans (for studies conducted in Canada, the USA, and Mexico).

3 Results

A total of 580 articles met the inclusion criteria mentioned above. Most of these studies discuss the use of antimicrobials and the resistance to them with respect to sample type. Table 2 presents the classification of data collections according to sample type and approach used for data analysis. The data available in this table suggest that 34% of studies have been based on the analysis of fecal or urine material used as a sample for AMR analysis. Moreover, 92% of the selected studies have been based on a laboratory analysis as an approach to detect antimicrobial resistance. We also report typical cases of antimicrobial resistance in Canada, the USA, and Mexico which were taken from the 67 articles (taken from the original list of 580 articles) that provided numerical estimates of antimicrobial resistance on North American farms. Tables 35, based on these 67 studies, present the AMR estimates (shown in percentages) reported for the 10 most frequent bacterial types detected and the 11 most used antibiotic classes used on North American farms. We can observe that E. coli and Salmonella were the most frequent bacteria affecting North American livestock in terms of AMR, and Penicillins and Tetracyclines were among the most used antibiotic classes triggering AMR.

Table 2
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Table 2. Main sample types and approaches considered to investigate antimicrobial use and resistance on North American farms.

Table 3
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Table 3. Typical cases of antimicrobial resistance (AMR) on Canadian farms (cattle, poultry, and pigs).

Table 4
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Table 4. Typical cases of antimicrobial resistance (AMR) on the US farms (cattle, poultry, and pigs).

Table 5
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Table 5. Typical cases of antimicrobial resistance (AMR) on Mexican farms (cattle, poultry, and pigs).

Comparing the average AMR rates across the three largest North American countries (see Tables 36 as well as Figures 35), one can observe the following trends: Regarding cattle, the USA have the lowest average AMR rate of 35.67%, followed by Canada with the average AMR rate of 49.60%, and Mexico with the highest average AMR rate of 64.45%. In contrast, in pig farming, Canada shows the highest average AMR rate of 67.86%, compared to Mexico with 55.80%, and the USA with 57.62%. Finally, for poultry, Canada shows the lowest average AMR rate at 25.31%, while the USA and Mexico have much higher average AMR rates of 42.96% and 42.45%, respectively. The related confidence intervals of the observed AMR cases are generally much longer for cattle than for pigs, and especially than for poultry that provide the lowest estimates. Obviously, the observed AMR rate depends highly on the antibiotic type being used and the bacterium being treated.

Table 6
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Table 6. Average AMR rates (in %) and the corresponding standard deviations (STD) obtained for food-producing animals in North America during the 2015–2024 time period.

Figure 3
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Figure 3. Average AMR rates on: (a) the temporal (by a two-year period within 2015–2024) and (b) the spatial (by North American country) scales. The associated 90% confidence intervals (CI) are shown.

Furthermore, we conducted a detailed analysis to compare separately, for cattle, poultry, and pigs raised on North American farms, the average AMR rates per antibiotic class (Figure 4) and per bacterium being treated (see Figure 5). A 90% confidence interval (CI) was calculated for each AMR estimate considered.

Figure 4
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Figure 4. Average AMR per antibiotic class rates for cattle, poultry, and pig farms in North America. The associated 90% confidence intervals are reported. (a) Average AMR per antibiotic for cattle in North America. (b) Average AMR per antibiotic for poultry in North America. (c) Average AMR per antibiotic for pigs in North America.

Figure 5
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Figure 5. Average AMR rates per bacterium for cattle, poultry, and pig farms in North America. The associated 90% confidence intervals are reported. (a) Average AMR per bacterium for cattle in North America. (b) Average AMR per bacterium for poultry in North America. (c) Average AMR per bacterium for pigs in North America.

Figure 4 illustrates the average AMR rates for each antibiotic class in cattle (a), poultry (b), and pigs (c) farms across North America. For cattle, the highest value of antibiotic resistance is observed with Cephalosporins – 71.42% on average [90% CI: 56.62% to 86.22%], for poultry, the highest AMR is observed with Tetracyclines – 51.21% on average [90% CI: 43.94% to 58,48%], while for pigs, the highest AMR is found with Penicillins - 74.7% on average [90% CI: 58.51% to 90.89%].

Figure 5 shows the average AMR rates per bacterium, characteristic for the cattle (a), poultry (b), and pig (c) farms in North America. The highest AMR for cattle is found with S. areaus – 69.02% on average [90% CI: 55.2% to 82.84%], for poultry, the highest AMR percentage is found with Enterococcus – 42.0% on average [90% CI: 34.26% to 49.74%], while for pigs, the highest AMR is observed with Streptococcus suis (S. suis) – 71.91% on average [90% CI: 53.45% to 90.37%].

Moreover, we determined that the highest average AMR rates have been observed for pigs – 60.63%, on average, the medium for cattle – 48.94%, on average, and the lowest for poultry – 28.43%, on average. The presented results indicate that Cephalosporines, Penicillins, and Tetracyclines are the antibiotic classes with the highest average AMR rate – 65.86%, 61.32%, and 58.82%, respectively, whereas the use of Sulfonamides and Quinolones leads to the lowest average AMR – 21.59% and 28.07%, respectively. Regarding antibiotic-resistant bacteria, we found that S. suis and S. auerus provide the highest average AMR rates – 71.81% and 69.48%, respectively, while Campylobacter spp. provides the lowest average AMR of 29.75%.

Table 6 reports the average AMR rates along with the corresponding standard deviations (STD) and 90% confidence intervals (CI) obtained for the 2015–2024 time period. The most important AMR percentage variations are observed for Cattle, followed by Pigs, and then by Poultry that correspond to the lowest AMR scores and STD values.

Figure 3a presents the average AMRs over two-year periods (from 2015 to 2024) in North American farms. The averages were calculated over all types of livestock and antimicrobials considered. We can observe an important trend consisting in the decrease of an average AMR from 57.5 % in 2015–2016 to 39.25% in 2019–2020. However, this trend was reversed in 2021–2022 and 2023–2024 as the AMR rate increased again, reaching the level of 52%. Figure 3b illustrates the spatial AMR pattern characteristic for North American food-producing animal farms. The highest average AMR percentage, 57.46%, was observed in Mexico, followed by Canada at 45.22%, and the USA at 42.25%. This trend can be explained by a better AMR control, carried out through different programs and strategies discussed above, existing in Canada and the USA, compared to Mexico.

4 Discussion

Nowadays, the use of antibiotics on farms to prevent bacterial propagation is a topic of discussion around the world (Holmes et al., 2016; Wu et al., 2023; Galiot et al., 2023; Mohsin et al., 2023; Gao et al., 2023). Obviously, antibiotics given to livestock have the benefits of treating, reducing, and preventing bacterial infections. However, the downside is also evident. Antibiotics impose strong selective pressure on microbial populations so that their excessive use in food-producing animals makes the targeted bacteria not only resistant to antimicrobials but also transferable to humans, thus contributing to the emergence of new antibiotic-resistant human pathogens (e.g., antibiotic-resistant bacteria can be easily transferred to humans through the consumption of meat, fruits, or vegetables) (O'Neill, 2016; Manyi-Loh et al., 2018; Salam et al., 2023; Kaur et al., 2024).

Several studies have suggested that AMU in animals can bring resistance to various zoonotic pathogens (Dutil et al., 2010; Rhouma et al., 2021; Innes et al., 2020; Huber et al., 2021; Ekakoro et al., 2019; Léger et al., 2022). Moreover, the transmission of antibiotic-resistant bacteria can go in the opposite direction, i.e., from humans to animals. This kind of transmission is much less studied, however. Some recent works in the field have been devoted to the investigation of different cases of human-to-animal transmission of antimicrobial resistance, involving pets (Haenni et al., 2012; Redding et al., 2023; Roken et al., 2022) and livestock (Khanna et al., 2008). Yet, AMR can be transmitted from humans to animals, and then be back to humans. Weese et al. indicated the presence of human clones of methicillin-resistant S. aureus in horses (Weese et al., 2005). Dierikx et al. discussed the presence of common human clones of multidrug-resistant Enterococcus in pets (Dierikx et al., 2012). Several recent studies argued that AMU in different animals can contribute to AMR to several animal pathogens (Beck et al., 2012; Agunos et al., 2019; Pinto et al., 2023; Ida et al., 2023; Ekhlas et al., 2023). A number of recent studies discussed the facts of transmission of antimicrobial resistance genes from animals to soil pathogens through manure and wastewater irrigation (Sancheza et al., 2016; Williams-Nguyen et al., 2016; Scott et al., 2018; Murray et al., 2019; Mays et al., 2021). For instance, antimicrobial resistance genes in surface and groundwater can propagate to indigenous organisms through horizontal gene transfer (HGT) (Boc and Makarenkov, 2011; Gou et al., 2018; Makarenkov et al., 2021). According to Dungan et al. (2018), manure containing antibiotic resistance genes (ARGs) is the most important propagation pathway in the environment. According to Qian et al. (2018), pig and chicken manures show a greater ARG diversity than cow manures. This can be explained by the fact that over their lifetime pigs and chickens usually receive a higher dosage of antibiotics than cows (Dunlop et al., 1998; Dewey, 1999). However, no qualitative or quantitative studies have been conducted so far to explain in detail the relationships between AMU and the emergence of ARG.

Today, many public and governmental organizations in North America continue to argue for reducing the use of antibiotics in livestock. According to Moreno (2012), a referendum involving 1,000 US residents showed that 72% of them were apprehensive about the excess of antibiotics in animal feed. In 2012, the US Food and Drug Administration forbade unapproved doses of cephalosporins (Cephalosporin Order of Prohibition Goes Into Effect).8 Still in 2012, Barbara Sibbald (Deputy Editor of Canadian Medical Association journal) raised a danger alert for stricter regulations on antibiotic use in farm animals in Canada (Sibbald, 2012). In the province of Quebec (Canada), the resistance of porcine Escherichia coli (E. coli) isolates to ceftiofur has increased from 0% in 1994 to 20% in 2011 (Surveillance de l'antibiorésistance-Rapport Annuel, 2011). Moreover, according to Park et al. (2013), 97% of the Staphylococcus hyicus isolates from pigs in the province of Ontario (Canada) have been resistant to penicillin G and ampicillin, whereas 71% of these isolates have been resistant to ceftiofur. A study conducted in the USA in 2023 revealed that Salmonella found in American poultry show a high resistance (73.1% on average) to multiple antibiotics, including fluoroquinolones and extended-spectrum cephalosporins. It poses a significant public health concern as these antibiotics are also commonly used to treat Salmonella infections in humans (Mujahid et al., 2023). Besides the commonly discussed antibiotics, antimicrobial resistance to pleuromutilins (Hayer et al., 2020a), lincosamides (Abdelfattah et al., 2021), amphenicols (Nobrega et al., 2018b), and chloramphenicols (Vounba et al., 2019) has also been observed in food-producing animals across North America. Although these antibiotics have been used less frequently, they still contribute to a broader issue of the AMR spread in livestock.

Certainly, the use of antibiotics in livestock around the world needs to be better analyzed and characterized by conducting new quantitative or qualitative studies and surveys as it has been recently done by Kimera et al. (2020) in an African perspective. Real-life data should be made available to allow decision-makers to know where we currently stand. This kind of studies can be used not only to compare the AMU and AMR relationships in different countries, but also to take action and help reduce unnecessary antimicrobial use. Denmark and the Netherlands are examples of countries that applied different AMR prevention approaches to reduce antibiotic usage in farm animals (Aarestrup et al., 2010). For example, by 2008 in Denmark, pig production was using less than 50% of antibiotics of the total they were using in 1992. The Netherlands launched, in 2009, a project intended to minimize the antibiotic use by 50% in three years. The proposed measures helped reduce sales of antibiotics in the Netherlands by 32% (Trends in Veterinary Antibiotic Use in the Netherlands 2005-2011, 2011). Since 2020, Norway has been implementing a cyclical approach to combat antimicrobial resistance based on a new national strategy (Rortveit and Simonsen, 2020). Rørtveit and Simonsen explored the key elements and the effectiveness of this approach, and described primary care perspective on the Norwegian national strategy against antimicrobial resistance (Rortveit and Simonsen, 2020).

The spread of antimicrobial resistant genes in livestock and their transfer to humans become more and more challenging issues not only in North America, but in many countries around the globe. The need for understanding how to reduce the transmission of ARG from food-producing animals to humans has become a topic of major importance.

To effectively address the potential health risks related to AMR, it is crucial to adopt the OneHealth approach (Asaaga et al., 2022) that highlights the need for collaboration between human, animal, and environmental health sectors to effectively mitigate AMR risks. This approach aims at tackling AMR by encouraging global collaboration, innovation, and accountability. It includes using antibiotics only when necessary for treatment, avoiding their use as growth promoters, and regulating their use in both humans and animals. By offering a comprehensive strategy, the OneHealth framework promotes stronger global governance, sustainable practices, and monitoring to control the spread of resistant bacteria. This integrated approach is essential to reduce AMR risks and ensure long-term health for all.

Some specific approaches have already shown their effectiveness in reducing the use of AMR in farms (Aarestrup et al., 2010; Trends in Veterinary Antibiotic Use in the Netherlands 2005-2011, 2011; Rortveit and Simonsen, 2020). They include creating a private place for infected animals, minimizing contacts between humans and animals, and optimizing waste collection. A deep understanding of the mechanisms related to animal maintenance is fundamental for understanding how livestock waste can accelerate the spread of AMR. Obviously, farmers should pay particular attention when they use antibiotics because not all bacterial infections need antibiotic treatment (Ventola, 2015). Thus, the increase in the number of sick animals on a farm is not a cause for antimicrobial misuse. Sometimes, inflammatory conditions, such as pancreatitis or neoplasia are considered and treated as bacterial infections. In many cases, incision and drainage represent an alternative for treatment of localized abscesses. Prevention in early times can also help heal a secondary bacterial infection without antimicrobials (Lhermie et al., 2018).

Spatio-temporal factors provide important information that can help policymakers, researchers, and veterinarians take action to reduce or prevent the spread of AMR (Asaduzzaman et al., 2022). For instance, a study by Sodagari et al. revealed higher levels of antimicrobial resistance in Escherichia coli isolates from eggs produced in cage-free systems compared to cage systems, particularly after the tetracycline and amoxicillin treatment (Sodagari et al., 2023). A study conducted by Novoa Rama examined the impact of housing systems on the prevalence and AMR of Campylobacter jejuni (C. jejuni). The results showed a higher prevalence of bacteria in hens from cage-free systems, with high resistance to tetracycline (67%) (Novoa Rama et al., 2018). These findings highlight the significance of housing systems as an environmental factor in the spatial distribution of AMR. In addition, the rearing period of animals plays a role in AMR development. Montoro-Dasi et al. (2020) compared two breeds of hens–one with rapid growth and the other with slow growth. The results suggest that fast-growing hens had higher AMR rates at the beginning of their rearing period. However, by the end of the growth period, no significant difference was observed between the two groups, indicating that AMR can develop rapidly under certain production conditions, even without antibiotic use. Thus, AMR dynamics are obviously influenced by both environmental and temporal factors, which should be considered when developing strategies to reduce AMR spread. This understanding can help inform more targeted intervention efforts and policies aimed at controlling AMR in agricultural settings.

AMU data can be considered as well to explore the relationship between the use of antimicrobials and the emergence of antimicrobial resistance to specific bacterial strains (Holmer et al., 2019). For example, the administration of ceftiofur in-ovo or to day-old chicks in hatcheries was associated with the emergence of the ceftiofur resistance in Salmonella Heidelberg found in the chicken meat. A noticeable reduction of this kind of AMR was observed when hatcheries in Quebec voluntarily ceased the in-ovo use of ceftiofur (Dutil et al., 2010). It has been shown that infections caused by antibiotic-resistant Campylobacter strains may lead to more frequent and prolonged hospitalizations compared to infections caused by non-resistant strains (Igwaran and Okoh, 2019). Campylobacter is one of the main source of bacterial foodborne and waterborne infections, including diarrhoeal diseases. Although most pig herds carry Campylobacter coli (C. coli), limited research has explored the relationship between AMU and AMR to Campylobacter in pigs (Tang et al., 2017a). This gap may be attributed to the prevailing focus on poultry as a primary source of human exposure to Campylobacter (Igwaran and Okoh, 2019). While campylobacteriosis is a less common cause of clinical illness in pigs, they still pose a potential risk for foodborne campylobacteriosis, environmental contamination, and exposure of farm workers to Campylobacter.

It is worth noting that the decrease in antibiotic use does not always decrease AMR. For example, Borgen et al. (2000) observed the persistence of vancomycin-resistant Enterococcus on Norwegian poultry farms even after the prohibition of the avoparcin. According to Lopatkin et al. (2017), the conjugation of plasmids carrying an antimicrobial gene can result in plasmid maintenance in a microbial community in the absence of antibiotics. It is imperative to embrace a fresh perspective that not only aims at decreasing antibiotic usage but also focuses on preventing the unification of resistance as well as on promoting the preservation of plasmids. Several alternatives to combat antimicrobial resistance have been proposed in the literature, including prebiotics (Hume, 2011; Cunningham et al., 2021; Yang et al., 2019), antimicrobial peptides (Rima et al., 2021; rudzynski K, 2015), and probiotics (Yaqoob et al., 2022; Lone et al., 2022). For example, prebiotics can help modify the animal's gut by regulating its immune systems (Pourabedin and Zhao, 2015). Ghosh et al. (2019) discussed the current state of these alternatives and highlighted the main difficulties of their implementation.

Furthermore, some strategies should be implemented to limit the transmission of antimicrobial resistance through the environment. For example, some preventive measures must be applied to manure storage and disposal. Farm workers should pay attention to conventional waste treatment. Disinfection with chlorine is a fundamental step to treat the wastewater on farms (Yuan et al., 2015). In addition, farmers need to stop applying livestock waste-amended manure to soils to prevent the transfer of AMR from soil pathogens to humans (National Antimicrobial Resistance Monitoring System (NARMS)).9

5 Conclusion

Food-producing animals have been identified as a significant contributor to the dissemination of antimicrobial resistance as indicated by the high levels of AMR observed in livestock in the three largest North American countries. High AMR rates, observed especially for cattle and pigs, can be a cause of transmission of AMR to humans who come in contact with farm animals, directly or indirectly through contaminated food products or the environment.

Our review only touches the surface of a vast global issue, which requires urgent attention and coordinated efforts of farmers and veterinarians. It is important to note that our study was not designed to recommend any specific type or level of restriction on antibiotic use. Our research is rather focused on quantifying and comparing AMR rates in food-producing animals, including cattle, poultry, and pigs, in North America. We reviewed the proposed solutions to combat AMR in the three largest North American countries and suggested some complementary strategies which could aid to reduce antimicrobial resistance in livestock. Our findings can be used to develop new policies and approaches to address this pressing global concern.

Data availability statement

The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.

Author contributions

MM: Writing – original draft, Writing – review & editing. AD: Writing – original draft, Writing – review & editing. VM: Writing – original draft, Writing – review & editing.

Funding

The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by Natural Sciences and Engineering Research Council of Canada (NSERC grant #249644 and NSERC Alliance grant).

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Generative AI statement

The author(s) declare that no Gen AI was used in the creation of this manuscript.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Abbreviations

AMU, Antimicrobial use; AMR, Antimicrobial resistance; ARG, Antimicrobial resistance gene; E. coli, Escherichia coli; C. jejuni, Campylobacter jejuni; S. aureus, Staphylococcus aureus; S. suis, Streptococcus suis; C. coli, Campylobacter coli; WGS, Whole-genome sequencing; MLST, Multi-locus sequence typing; PCR, Polymerase Chain Reaction; PFGE, Pulse-field gel electrophoresis; qPCR, Quantitative PCR; NGS, Next generation sequencing; NAS, Non-aureus staphylococci; CI, Confidence Interval; STD, Standard Deviation.

Footnotes

References

Aarestrup, F. M., Jensen, V. F., Emborg, H. D., Jacobsen, E., and Wegener, H. C. (2010). Changes in the use of antimicrobials and the effects on productivity of swine farms in denmark. Am. J. Vet. Res. 71:726–733. doi: 10.2460/ajvr.71.7.726

PubMed Abstract | Crossref Full Text | Google Scholar

Abdelfattah, E. M., Ekong, P. S., Okello, E., Chamchoy, T., Karle, B. M., Black, R. A., et al. (2021). Epidemiology of antimicrobial resistance (AMR) on california dairies: descriptive and cluster analyses of AMR phenotype of fecal commensal bacteria isolated from adult cows. PeerJ 9:11108. doi: 10.7717/peerj.11108

PubMed Abstract | Crossref Full Text | Google Scholar

Abdi, R., Gillespie, B. E., Vaughn, J., Merrill, C., Ensermu, D. B., et al. (2018). Antimicrobial resistance of Staphylococcus aureus isolates from dairy cows and genetic diversity of resistant isolates. Foodborne Pathog. Dis. 15, 449–458. doi: 10.1089/fpd.2017.2362

PubMed Abstract | Crossref Full Text | Google Scholar

Adator, E., Narvaez-Bravo, C., Zaheer, R., Cook, S., Tymensen, L., Hannon, S., et al. (2022). A one health comparative assessment of antimicrobial resistance in generic and extended-spectrum cephalosporin-resistant Escherichia coli from beef production, sewage and clinical settings. Microorganisms 8:885. doi: 10.3390/microorganisms8060885

PubMed Abstract | Crossref Full Text | Google Scholar

Aguilar-Montes de Oca, S., Talavera-Rojas, M., Soriano-Vargas, E., Barba-León, J., and Vazquez-Navarrete, J. (2015). Determination of extended spectrum beta-lactamases/ampc beta-lactamases and plasmid-mediated quinolone resistance in Escherichia coli isolates obtained from bovine carcasses in Mexico. Trop. Anim. Health Prod. 47, 975–981. doi: 10.1007/s11250-015-0818-3

PubMed Abstract | Crossref Full Text | Google Scholar

Aguilar-Montes de Oca, S., Talavera-Rojas, M., Soriano-Vargas, E., Barba-León, J., Vázquez-Navarrete, J., Acosta-Dibarrat, J., et al. (2018). Phenotypic and genotypic profile of clinical and animal multidrug-resistant salmonella enterica isolates from mexico. J. Appl. Microbiol. 124, 67–74. doi: 10.1111/jam.13615

PubMed Abstract | Crossref Full Text | Google Scholar

Agunos, A., Gow, S. P., Léger, D. F., Carson, C. A., Deckert, A. E., Bosman, A. L., et al. (2019). Antimicrobial use and antimicrobial resistance indicators-integration of farm-level surveillance data from broiler chickens and turkeys in british columbia, Canada. Front Vet Sci 6:131. doi: 10.3389/fvets.2019.00131

PubMed Abstract | Crossref Full Text | Google Scholar

almada Corral, A., Cordero-Ortiz, M., LD, B.-H., Calderén-Montoya, S., Bolado-Martínez, E., Sánchez-Mariñez, R., et al. (2023). Evaluation of antimicrobial susceptibility and genetic profiles (ERIC-PCR) of enterococcus species isolated from chicken viscera. Biotecnia 25:169–175. doi: 10.18633/biotecnia.v25i1.1869

Crossref Full Text | Google Scholar

Anomaly, J. (2015). What's wrong with factory farming? Public Health Ethics 8:246–254. doi: 10.1093/phe/phu001

PubMed Abstract | Crossref Full Text | Google Scholar

Antimicrobial Stewardship in Companion Animal Practice (2015). Antimicrobial stewardship in companion animal practice. J. Am. Vet. Med. Assoc. 246, 287–288. doi: 10.2460/javma.246.3.287

PubMed Abstract | Crossref Full Text | Google Scholar

Antimicrobial Use and Stewardship (Aus) Program Report to the Legislature, California, USA (2019). Available online at: https://www.cdfa.ca.gov/ahfss/aus/docs/CDFA_AUS_Report_2019.pdf

Google Scholar

Aradanas, M., Poljak, Z., Fittipaldi, N., Ricker, N., and Farzan, A. (2021). Serotypes, virulence-associated factors, and antimicrobial resistance of streptococcus suis isolates recovered from sick and healthy pigs determined by whole-genome sequencing. Front Vet Sci 8:742345. doi: 10.3389/fvets.2021.742345

PubMed Abstract | Crossref Full Text | Google Scholar

Arndt, E. R., Farzan, A., MacInnes, J. I., and Friendship, R. M. (2019). Antimicrobial resistance of streptococcus suis isolates recovered from clinically ill nursery pigs and from healthy pigs at different stages of production. Can. Vet. J. 60, 519–522.

PubMed Abstract | Google Scholar

Asaaga, F., Young, J. C., Srinivas, P. N., Seshadri, T., Oommen, M. A., Rahman, M., et al. (2022). Co-production of knowledge as part of a onehealth approach to better control zoonotic diseases. PLOS Glob. Public Health 2:e0000075. doi: 10.1371/journal.pgph.0000075

PubMed Abstract | Crossref Full Text | Google Scholar

Asaduzzaman, M., Rousham, E., Unicomb, L., and et al. (2022). Spatiotemporal distribution of antimicrobial resistant organisms in different water environments in urban and rural settings of Bangladesh. Sci. Total Environ. 831:154890. doi: 10.1016/j.scitotenv.2022.154890

PubMed Abstract | Crossref Full Text | Google Scholar

Awosile, B., McClure, J., Sanchez, J., C, R.-L. J., Keefe, G., and L. C., et al. (2018). Salmonella enterica and extended-spectrum cephalosporin-resistant Escherichia coli recovered from holstein dairy calves from 8 farms in new Brunswick, Canada. J. Dairy Sci. 101, 3271–3284. doi: 10.3168/jds.2017-13277

PubMed Abstract | Crossref Full Text | Google Scholar

Awosile, B., McClure, J., Sanchez, J., VanLeeuwen, J., Rodriguez-Lecompte, J., Keefe, G., et al. (2017). Short communication: extended-spectrum cephalosporin-resistant Escherichia coli in colostrum from New Brunswick, Canada, dairy cows harbor blacmy-2 and blatem resistance genes. J. Dairy Sci. 100, 7901–7905. doi: 10.3168/jds.2017-12941

PubMed Abstract | Crossref Full Text | Google Scholar

Beck, K. M., Waisglass, S. E., Dick, H. L., and Weese, J. S. (2012). Prevalence of meticillin-resistant Staphylococcus pseudintermedius (MRSP) from skin and carriage sites of dogs after treatment of their meticillin-resistant or meticillin-sensitive staphylococcal pyoderma. Vet. Dermatol. 23, 369–e67. doi: 10.1111/j.1365-3164.2012.01035.x

PubMed Abstract | Crossref Full Text | Google Scholar

Beier, R., Andrews, K., Hume, M., Sohail, M., Harvey, R., Poole, T., et al. (2021). Disinfectant and antimicrobial susceptibility studies of Staphylococcus aureus strains and st398-MRSA and st5-mrsa strains from swine mandibular lymph node tissue, commercial pork sausage meat and swine feces. Microorganisms 9:2401. doi: 10.3390/microorganisms9112401

PubMed Abstract | Crossref Full Text | Google Scholar

Boc, A., and Makarenkov, V. (2011). Towards an accurate identification of mosaic genes and partial horizontal gene transfers. Nucleic Acids Res. 39, e144–e144. doi: 10.1093/nar/gkr735

PubMed Abstract | Crossref Full Text | Google Scholar

Borgen, K., Simonsen, G. S., Sundsfjord, A., Wasteson, Y., Olsvik, O., and Kruse, H. (2000). Continuing high prevalence of vana-type vancomycin-resistant enterococci on norwegian poultry farms three years after avoparcin was banned. J. Appl. Microbiol. 89, 478–485. doi: 10.1046/j.1365-2672.2000.01137.x

PubMed Abstract | Crossref Full Text | Google Scholar

Brown, E. E. F., Cooper, A., Carrillo, C., and Blais, B. (2019). Selection of multidrug-resistant bacteria in medicated animal feeds. Front. Microbiol. 10:456. doi: 10.3389/fmicb.2019.00456

PubMed Abstract | Crossref Full Text | Google Scholar

Cameron, A., Zaheer, R., Adator, E. H., Barbieri, R., Reuter, T., and McAllister, T. A. (2019). Bacteriocin occurrence and activity in Escherichia coli isolated from bovines and wastewater. Toxins 11:475. doi: 10.3390/toxins11080475

PubMed Abstract | Crossref Full Text | Google Scholar

Canizalez-Roman, A., Velazquez-Roman, J., Valdez-Flores, M. A., Flores-Villaseñor, H., Vidal, J. E., Muro-Amador, S., et al. (2019). Detection of antimicrobial-resistance diarrheagenic Escherichia coli strains in surface water used to irrigate food products in the northwest of mexico. Int. J. Food Microbiol. 304, 1–10. doi: 10.1016/j.ijfoodmicro.2019.05.017

PubMed Abstract | Crossref Full Text | Google Scholar

Carroll, L. M., Wiedmann, M., den Bakker, H., Siler, J., Warchocki, S., Kent, D., et al. (2017). Whole-genome sequencing of drug-resistant salmonella enterica isolates from dairy cattle and humans in new york and washington states reveals source and geographic associations. Appl. Environ. Microbiol. 83, e00140–e00117. doi: 10.1128/AEM.00140-17

PubMed Abstract | Crossref Full Text | Google Scholar

Chriki, S., and Hocquette, J. F. (2020). The myth of cultured meat: a review. Front. Nutr. 7:7. doi: 10.3389/fnut.2020.00007

PubMed Abstract | Crossref Full Text | Google Scholar

Christidis, T., Hurst, M., Rudnick, W., and Pintar, K. D. M. (2020). A comparative exposure assessment of foodborne, animal contact and waterborne transmission routes of salmonella in canada. Food Contr. 109:106899. doi: 10.1016/j.foodcont.2019.106899

Crossref Full Text | Google Scholar

Cobo-Angel, C., and Gohar, B. L. S. (2022). Values and risk perception shape canadian dairy farmers' attitudes toward prudent use of antimicrobials. Antibiotics 11:550. doi: 10.3390/antibiotics11050550

PubMed Abstract | Crossref Full Text | Google Scholar

College of Veterinarians of Ontario (2017). Setting an Action Agenda for Veterinary Stewardship of Antibiotic Use in Food-Producing Animals in Ontario. Available online at: viewer.joomag.com/growing-forward-2-final-report-project-ii/0379250001512484479?short (accessed March, 2024).

Google Scholar

Cormier, A. C., Chalmers, G., Cook, S. R., Zaheer, R., Hannon, S. J., Booker, C. W., et al. (2020). Presence and diversity of extended-spectrum cephalosporin resistance among Escherichia coli from urban wastewater and feedlot cattle in Alberta, Canada. Microb. Drug Resist. 26:300–309. doi: 10.1089/mdr.2019.0112

PubMed Abstract | Crossref Full Text | Google Scholar

Cox, G. W., Parmley, E. J., Avery, B. P., Irwin, R. J., Reid-Smith, R. J., Deckert, A. E., et al. (2021). A one-health genomic investigation of gentamicin resistance in salmonella from human and chicken sources in Canada, 2014 to 2017. Antimicrob. Agents Chemother. 65:e0096621. doi: 10.1128/aac.00677-22

PubMed Abstract | Crossref Full Text | Google Scholar

Cunningham, M., Azcarate-Peril, M. A., Barnard, A., Benoit, V., andGrimaldi, R., Guyonnet, D., et al. (2021). Shaping the future of probiotics and prebiotics. Trends Microbiol. 29, 667–685. doi: 10.1016/j.tim.2021.01.003

PubMed Abstract | Crossref Full Text | Google Scholar

Dalton, K. R., Rock, C., Carroll, K. C., and Davis, M. F. (2020). One health in hospitals: how understanding the dynamics of people, animals, and the hospital built-environment can be used to better inform interventions for antimicrobial-resistant gram-positive infections. Antimicrob. Resist. Infect. Control 9:78. doi: 10.1186/s13756-020-00737-2

PubMed Abstract | Crossref Full Text | Google Scholar

Dargatz, D., Kopral, C., Erdman, M., and Fedorka-Cray, P. (2016). Prevalence and antimicrobial resistance of salmonella isolated from cattle feces in united states feedlots in 2011. Foodborne Pathog. Dis. 13, 483–489. doi: 10.1089/fpd.2016.2128

PubMed Abstract | Crossref Full Text | Google Scholar

Davedow, T., Narvaez-Bravo, C., Zaheer, R., Sanderson, H., A, R.-G., Klima, C., et al. (2020). Investigation of a reduction in tylosin on the prevalence of liver abscesses and antimicrobial resistance in enterococci in feedlot cattle. Front Vet Sci 7:3389. doi: 10.3389/fvets.2020.00090

PubMed Abstract | Crossref Full Text | Google Scholar

Delgado-Suárez, E. J., Ortíz-López, R., Gebreyes, W. A., Allard, M. W., Barona-Gómez, F., and Rubio-Lozano, M. S. (2019). Genomic surveillance links livestock production with the emergence and spread of multi-drug resistant non-typhoidal salmonella in Mexico. J. Microbiol. 57:271–280. doi: 10.1007/s12275-019-8421-3

PubMed Abstract | Crossref Full Text | Google Scholar

Delgado-Suárez, E. J., Palós-Guitérrez, T., Ruíz-López, F. A., Hernández Pérez, C. F., Ballesteros-Nova, N. E., Soberanis-Ramos, O., et al. (2021). Genomic surveillance of antimicrobial resistance shows cattle and poultry are a moderate source of multi-drug resistant non-typhoidal salmonella in mexico. PLoS ONE 16:e0243681. doi: 10.1371/journal.pone.0243681

PubMed Abstract | Crossref Full Text | Google Scholar

Dewey, C. E. (1999). Use of antimicrobials in swine feeds in the united states. Swine Health Prod 7, 19–25.

Google Scholar

Dharmarha, V., Guron, G., Boyer, R. R., Niemira, B. A., Pruden, A., Strawn, L. K., et al. (2019). Gamma irradiation influences the survival and regrowth of antibiotic-resistant bacteria and antibiotic-resistance genes on romaine lettuce. Front. Microbiol. 10:710. doi: 10.3389/fmicb.2019.00710

PubMed Abstract | Crossref Full Text | Google Scholar

Dierikx, C. M., van Duijkeren, E., Schoormans, A. H., van Essen-Zandbergen, A., Veldman, K., Kant, A., et al. (2012). Occurrence and characteristics of extended-spectrum-beta-lactamase and ampc-producing clinical isolates derived from companion animals and horses. J. Antimicrob. Chemother. 67, 1368–1374. doi: 10.1093/jac/dks049

PubMed Abstract | Crossref Full Text | Google Scholar

Doster, E., Pinnell, L., Noyes, N., Parker, J., Anderso, C., Booker, C., et al. (2022). Evaluating the effects of antimicrobial drug use on the ecology of antimicrobial resistance and microbial community structure in beef feedlot cattle. Front. Microbiol. 13:970358. doi: 10.3389/fmicb.2022.970358

PubMed Abstract | Crossref Full Text | Google Scholar

Dramé, O., Leclair, D., Parmley, E. J., Deckert, A., Ouattara, B., Daignault, D., et al. (2020). Antimicrobial resistance of campylobacter in broiler chicken along the food chain in Canada. Foodborne Pathog. Dis. 17, 512–20. doi: 10.1089/fpd.2019.2752

PubMed Abstract | Crossref Full Text | Google Scholar

Drouillard, J. S. (2018). Current situation and future trends for beef production in the United States of America - a review. Asian-Australas. J. Anim. Sci. 31, 1007–1016. doi: 10.5713/ajas.18.0428

PubMed Abstract | Crossref Full Text | Google Scholar

Dungan, R. S., McKinney, C. W., and Leytem, A. B. (2018). Tracking antibiotic resistance genes in soil irrigated with dairy wastewater. Sci. Total Environ. 635:1477–1483. doi: 10.1016/j.scitotenv.2018.04.020

PubMed Abstract | Crossref Full Text | Google Scholar

Dunlop, R. H., McEwen, S. A., Meek, A. H., Friendship, R. A., Clarke, R. C., and Black, W. D. (1998). Antimicrobial drug use and related management practices among Ontario swine producers. Can. Vet. J. 39, 87–96.

Google Scholar

Dutil, L., Irwin, R., Finley, R. N. L. K., Avery, B., Boerlin, P., Bourgault, A. M., et al. (2010). Ceftiofur resistance in salmonella enterica serovar heidelberg from chicken meat and humans, Canada. Emerging Infect. Dis. 16, 48–54. doi: 10.3201/eid1601.090729

PubMed Abstract | Crossref Full Text | Google Scholar

Ekakoro, J. E., Caldwell, M., Strand, E. B., and Okafor, C. C. (2019). Drivers, alternatives, knowledge, and perceptions towards antimicrobial use among tennessee beef cattle producers: a qualitative study. BMC Vet. Res. 15:16. doi: 10.1186/s12917-018-1731-6

PubMed Abstract | Crossref Full Text | Google Scholar

Ekhlas, D., Argüello, H., Leonard, F. C., Manzanilla, E. G., and Burgess, C. M. (2023). Insights on the effects of antimicrobial and heavy metal usage on the antimicrobial resistance profiles of pigs based on culture-independent studies. Vet. Res. 54:14. doi: 10.1186/s13567-023-01143-3

PubMed Abstract | Crossref Full Text | Google Scholar

Enciso-Martínez, Y., Barrios-Villa, E., Sepúlveda-Moreno, C. O., Ballesteros-Monrreal, M. G., Valencia-Rivera, D. E., González-Aguilar, G. A., et al. (2022). Prevalence of antibiotic-resistant E. coli strains in a local farm and packing facilities of honeydew melon in Hermosillo, Sonora, Mexico. Antibiotics 11:1789. doi: 10.3390/antibiotics11121789

PubMed Abstract | Crossref Full Text | Google Scholar

Engberg, J., Aarestrup, F. M., Taylor, D. E., Gerner-Smidt, P., and Nachamkin, I. (2001). Quinolone and macrolide resistance in campylobacter jejuni and c. coli: resistance mechanisms and trends in human isolates. Emerging Infect. Dis. 7:491. doi: 10.3201/eid0701.010104

PubMed Abstract | Crossref Full Text | Google Scholar

Fonseca, M., Heider, L., Stryhn, H., McClure, J., Léger, D., Rizzo, D., et al. (2023). Frequency of isolation and phenotypic antimicrobial resistance of fecal salmonella enterica recovered from dairy cattle in Canada. J. Dairy Sci. 23, 00760–00769. doi: 10.3168/jds.2023-23937

PubMed Abstract | Crossref Full Text | Google Scholar

Fujita, A. W., Werner, K., Jacob, J. T., Tschopp, R., Mamo, G., Mihret, A., et al. (2022). Antimicrobial resistance through the lens of one health in ethiopia: a review of the literature among humans, animals, and the environment. Int. J. Infect. Dis. 119, 120–129. doi: 10.1016/j.ijid.2022.03.041

PubMed Abstract | Crossref Full Text | Google Scholar

Galiot, L., Monger, X. C., and Vincent, A. T. (2023). Studying the association between antibiotic resistance genes and insertion sequences in metagenomes: challenges and pitfalls. Antibiotics 12:175. doi: 10.3390/antibiotics12010175

PubMed Abstract | Crossref Full Text | Google Scholar

Gao, F. Z., He, L. Y., Bai, H., He, L. X., Zhang, M., Chen, Z. Y., et al. (2023). Airborne bacterial community and antibiotic resistome in the swine farming environment: metagenomic insights into livestock relevance, pathogen hosts and public risks. Environ. Int. 172:107751. doi: 10.1016/j.envint.2023.107751

PubMed Abstract | Crossref Full Text | Google Scholar

Ghosh, C., Sarkar, P., Issa, R., and Haldar, J. (2019). Alternatives to conventional antibiotics in the era of antimicrobial resistance. Trends Microbiol. 27, 323–338. doi: 10.1016/j.tim.2018.12.010

PubMed Abstract | Crossref Full Text | Google Scholar

Godínez-Oviedo, A., Sampedro, F., Bowman, J. P., andGarcés-Vega, F. J., and Hernández-Iturriaga, M. (2023). Risk ranking of food categories associated with salmonella enterica contamination in the central region of mexico. Risk Anal. 43, 308–323. doi: 10.1111/risa.13907

PubMed Abstract | Crossref Full Text | Google Scholar

Gou, M., Hu, H. W., Zhang, Y. J., Wang, J. T., Hayden, H., Tang, Y. Q., et al. (2018). Aerobic composting reduces antibiotic resistance genes in cattle manure and the resistome dissemination in agricultural soils. Sci. Total Environ. 612, 1300–1310. doi: 10.1016/j.scitotenv.2017.09.028

PubMed Abstract | Crossref Full Text | Google Scholar

Graham, J. P., Evans, S. L., Price, L. B., and Silbergeld, E. K. (2009). Fate of antimicrobial-resistant enterococci and staphylococci and resistance determinants in stored poultry litter. Environ. Res. 109, 682–689. doi: 10.1016/j.envres.2009.05.005

PubMed Abstract | Crossref Full Text | Google Scholar

Graham, J. P., and Nachman, K. E. (2010). Managing waste from confined animal feeding operations in the United States: the need for sanitary reform. J. Water Health 8, 646–670. doi: 10.2166/wh.2010.075

PubMed Abstract | Crossref Full Text | Google Scholar

Guzmán-Rodríguez, J., Salinas-Pérez, E., León-Galván, F., Barboza-Corona, J. E., Valencia-Posadas, M., Ávila-Ramos, F., et al. (2021). Relationship between antibiotic resistance and biofilm production of Staphylococcus aureus isolates from bovine mastitis. Rev. Mex. De cienc. Pecuarias 12, 1117–1132. doi: 10.22319/rmcp.v12i4.5645

Crossref Full Text | Google Scholar

Haenni, M., Saras, E., Châtre, P., Médaille, C., Bes, M., Madec, J. Y., et al. (2012). A usa300 variant and other human-related methicillin-resistant Staphylococcus aureus strains infecting cats and dogs in france. J. Antimicrob. Chemother. 67:326–329. doi: 10.1093/jac/dkr499

PubMed Abstract | Crossref Full Text | Google Scholar

Hailu, W., Helmy, Y. A., Carney-Knisely, G., Kauffman, M., Fraga, D., and Rajashekara, G. (2021). Prevalence and antimicrobial resistance profiles of foodborne pathogens isolated from dairy cattle and poultry manure amended farms in northeastern Ohio, the United States. Antibiotics 10:1450. doi: 10.3390/antibiotics10121450

PubMed Abstract | Crossref Full Text | Google Scholar

Hau, S. J., Frana, T., Sun, J., Davies, P. R., and Nicholson, T. L. (2017). Zinc resistance within swine-associated methicillin-resistant staphylococcus aureus isolates in the united states is associated with multilocus sequence type lineage. Appl Environ Microbiol 83:e00756-17. doi: 10.1128/AEM.00756-17

PubMed Abstract | Crossref Full Text | Google Scholar

Hau, S. J., Haan, J. S., Davies, P. R., Frana, T., and Nicholson, T. L. (2018). Antimicrobial resistance distribution differs among methicillin resistant staphylococcus aureus sequence type (ST) 5 isolates from health care and agricultural sources. Front. Microbiol. 9:2102. doi: 10.3389/fmicb.2018.02102

PubMed Abstract | Crossref Full Text | Google Scholar

Hayer, S., Rovira, A., Olsen, K., Johnson, T., Vannucci, F., Rendahl, A., et al. (2020a). Prevalence and trend analysis of antimicrobial resistance in clinical Escherichia coli isolates collected from diseased pigs in the usa between 2006 and 2016. Transbound. Emerg. Dis. 67, 1930–1941. doi: 10.1111/tbed.13528

PubMed Abstract | Crossref Full Text | Google Scholar

Hayer, S. S., Lim, S., Hong, S., Elnekave, E., Johnson, T., Rovira, A., et al. (2020b). Genetic determinants of resistance to extended-spectrum cephalosporin and fluoroquinolone in Escherichia coli isolated from diseased pigs in the united states. mSphere 5, e00990–e00920. doi: 10.1128/mSphere.00990-20

PubMed Abstract | Crossref Full Text | Google Scholar

Heiman, K. E., Mody, R. K., Johnson, S. D., Griffin, P. M., and Gould, L. H. (2015). Escherichia coli o157 outbreaks in the United States, 2003-2012. Emerg. Infect. Dis. 21, 1293–1301. doi: 10.3201/eid2108.141364

PubMed Abstract | Crossref Full Text | Google Scholar

Holman, D. B., Hao, X., Topp, E., Yang, H. E., and Alexander, T. W. (2016). Effect of co-composting cattle manure with construction and demolition waste on the archaeal, bacterial, and fungal microbiota, and on antimicrobial resistance determinants. PLoS ONE 11:e0157539. doi: 10.1371/journal.pone.0157539

PubMed Abstract | Crossref Full Text | Google Scholar

Holmer, I., Salomonsen, C. M., Jorsal, S. E., Astrup, L. B., Jensen, V. F., Borck Høg, B., et al. (2019). Antibiotic resistance in porcine pathogenic bacteria and relation to antibiotic usage. BMC Vet. Res. 15:449. doi: 10.1186/s12917-019-2162-8

PubMed Abstract | Crossref Full Text | Google Scholar

Holmes, A. H., Moore, L. S., Sundsfjord, A., Steinbakk, M., Regmi, S., Karkey, A., et al. (2016). Understanding the mechanisms and drivers of antimicrobial resistance. Lancet 387, 176–187. doi: 10.1016/S0140-6736(15)00473-0

PubMed Abstract | Crossref Full Text | Google Scholar

Hsieh Y. C. Poole T. L. Runyon M. Hume M. and J. H. T. (2016). Prevalence of nontyphoidal salmonella and salmonella strains with conjugative antimicrobial-resistant serovars contaminating animal feed in texas. J. Food Prot. 79, 194–204. doi: 10.4315/0362-028X.JFP-15-163

PubMed Abstract | Crossref Full Text | Google Scholar

Huang, H., Brooks, B. W., Lowman, R., and Carrillo, C. D. (2015). Campylobacter species in animal, food, and environmental sources, and relevant testing programs in Canada. Can. J. Microbiol. 61, 701–721. doi: 10.1139/cjm-2014-0770

PubMed Abstract | Crossref Full Text | Google Scholar

Huber, L., Agunos, A., Gow, S. P., Carson, C. A., and Van Boeckel, T. P. (2021). Reduction in antimicrobial use and resistance to salmonella, campylobacter, and Escherichia coli in broiler chickens, Canada, 2013-2019. Emerging Infect. Dis. 27, 2434–2444. doi: 10.3201/eid2709.204395

PubMed Abstract | Crossref Full Text | Google Scholar

Huijbers, P. M., Blaak, H., de Jong, M. C., Graat, E. A., Vandenbroucke-Grauls, C. M., and de Roda Husman, A. M. (2015). Role of the environment in the transmission of antimicrobial resistance to humans: a review. Environm. Sci. Technol. 49, 11993–12004. doi: 10.1021/acs.est.5b02566

PubMed Abstract | Crossref Full Text | Google Scholar

Hull, D. M., Harrell, E., van Vliet, A. H. M., Correa, M., and Thakur, S. (2021). Antimicrobial resistance and interspecies gene transfer in campylobacter coli and campylobacter jejuni isolated from food animals, poultry processing, and retail meat in north carolina 2018-2019. PLoS ONE 16:e0246571. doi: 10.1371/journal.pone.0246571

PubMed Abstract | Crossref Full Text | Google Scholar

Hume, M. E. (2011). Historic perspective: prebiotics, probiotics, and other alternatives to antibiotics. Poult. Sci. 90, 2663–2669. doi: 10.3382/ps.2010-01030

PubMed Abstract | Crossref Full Text | Google Scholar

Ibekwe, A. M., Bhattacharjee, A. S., Phan, D., Ashworth, D., Schmidt, M. P., Murinda, S. E., et al. (2023). Potential reservoirs of antimicrobial resistance in livestock waste and treated wastewater that can be disseminated to agricultural land. Sci. Total Environ. 872:162194. doi: 10.1016/j.scitotenv.2023.162194

PubMed Abstract | Crossref Full Text | Google Scholar

Ida, J. A., Wilson, W. M., Nydam, D. V., Gerlach, S. C., Kastelic, J. P., Russell, E. R., et al. (2023). Contextualized understandings of dairy farmers' perspectives on antimicrobial use and regulation in Alberta, Canada. J. Dairy Sci. 106, 547–564. doi: 10.3168/jds.2021-21521

PubMed Abstract | Crossref Full Text | Google Scholar

Igwaran, A., and Okoh, A. (2019). Human campylobacteriosis: a public health concern of global importance. Heliyon 5:e02814. doi: 10.1016/j.heliyon.2019.e02814

PubMed Abstract | Crossref Full Text | Google Scholar

Innes, G. K., Randad, P. R., Korinek, A., Davis, M. F., Price, L. B., So, A. D., et al. (2020). External societal costs of antimicrobial resistance in humans attributable to antimicrobial use in livestock. Annu. Rev. Public Health 41, 141–157. doi: 10.1146/annurev-publhealth-040218-043954

PubMed Abstract | Crossref Full Text | Google Scholar

Jahanbakhsh, S., Kabore, K., Fravalo, P., Letellier, A., and Fairbrother, J. (2015). Impact of medicated feed along with clay mineral supplementation on Escherichia coli resistance to antimicrobial agents in pigs after weaning in field conditions. Res. Vet. Sci. 102, 72–79. doi: 10.1016/j.rvsc.2015.07.014

PubMed Abstract | Crossref Full Text | Google Scholar

Jahanbakhsh, S., Letellier, A., and Fairbrother, J. (2016a). Circulating of cmy-2 β-lactamase gene in weaned pigs and their environment in a commercial farm and the effect of feed supplementation with a clay mineral. J. Appl. Microbiol. 121, 136–148. doi: 10.1111/jam.13166

PubMed Abstract | Crossref Full Text | Google Scholar

Jahanbakhsh, S., Smith, M., Kohan-Ghadr, H., Letellier, A., Abraham, S., Trott, D., et al. (2016b). Dynamics of extended-spectrum cephalosporin resistance in pathogenic Escherichia coli isolated from diseased pigs in Quebec, Canada. Int. J. Antimicrob. Agents 48, 194–202. doi: 10.1016/j.ijantimicag.2016.05.001

PubMed Abstract | Crossref Full Text | Google Scholar

JAwosile, B., Heider, L., Saab, M., and McClure, J. (2018). Antimicrobial resistance in mastitis, respiratory and enteric bacteria isolated from ruminant animals from the atlantic provinces of Canada from 1994-2013. Can. Vet. J. 59, 1099–1104.

PubMed Abstract | Google Scholar

Jeamsripong, S., Li, X., Aly, S. S., Su, Z., Pereira, R. V., and Atwill, E. R. (2021). Antibiotic resistance genes and associated phenotypes in Escherichia coli and enterococcus from cattle at different production stages on a dairy farm in central california. Antibiotics 10:1042. doi: 10.3390/antibiotics10091042

PubMed Abstract | Crossref Full Text | Google Scholar

Kahn, L. H. (2017). Antimicrobial resistance: a one health perspective. Trans. R. Soc. Trop. Med. Hyg. 111, 255–260. doi: 10.1093/trstmh/trx050

PubMed Abstract | Crossref Full Text | Google Scholar

Kaur, K., Singh, S., and Kaur, R. (2024). Impact of antibiotic usage in food-producing animals on food safety and possible antibiotic alternatives. The Microbe 4:100097. doi: 10.1016/j.microb.2024.100097

Crossref Full Text | Google Scholar

Khanna, T., Friendship, R., Dewey, C., and Weese, J. S. (2008). Methicillin resistant Staphylococcus aureus colonization in pigs and pig farmers. Vet. Microbiol. 128, 298–303. doi: 10.1016/j.vetmic.2007.10.006

PubMed Abstract | Crossref Full Text | Google Scholar

Kimera, Z. I., Mshana, S. E., Rweyemamu, M. M., Mboera, L. E., and Matee, M. I. (2020). Antimicrobial use and resistance in food-producing animals and the environment: an african perspective. Antimicrob. Resist. Infect. Cont. 9, 1–12. doi: 10.1186/s13756-020-0697-x

PubMed Abstract | Crossref Full Text | Google Scholar

Kotwani, A., Joshi, J., and Kaloni, D. (2021). Pharmaceutical effluent: a critical link in the interconnected ecosystem promoting antimicrobial resistance. Environ. Sci. Pollut. Res. Int. 28:32111–32124. doi: 10.1007/s11356-021-14178-w

PubMed Abstract | Crossref Full Text | Google Scholar

Lee, K., Atwill, E., Pitesky, M., Huang, A., Lavelle, K., Rickard, M., et al. (2018). Antimicrobial resistance profiles of non-typhoidal salmonella from retail meat products in california, 2018. Front. Microbiol. 16:835699. doi: 10.3389/fmicb.2022.835699

PubMed Abstract | Crossref Full Text | Google Scholar

Lees, P., Pelligand, L., Giraud, E., and Toutain, P. (2021). A history of antimicrobial drugs in animals: Evolution and revolution. J. Vet. Pharmacol. Ther. 44, 137–171. doi: 10.1111/jvp.12895

PubMed Abstract | Crossref Full Text | Google Scholar

Léger, D. F., Anderson, M. E. C., Béedard, F. D., Burns, T., Carson, C. A., Deckert, A. E., et al. (2022). Canadian collaboration to identify a minimum dataset for antimicrobial use surveillance for policy and intervention development across food animal sectors. Antibiotics 11:226. doi: 10.3390/antibiotics11020226

PubMed Abstract | Crossref Full Text | Google Scholar

Levent, G., Schlochtermeier, A., Vinasco, J., Jennings, J., J, R., Ives, S., et al. (2022). Long-term effects of single-dose cephalosporin or macrolide use on the prevalence of AMPC and extended-spectrum β-lactamase producing Escherichia coli in the feces of beef cattle. Microorganisms 10:2071. doi: 10.3390/microorganisms10102071

PubMed Abstract | Crossref Full Text | Google Scholar

Lhermie, G., Tauer, L. W., and Gröhn, Y. T. (2018). The farm cost of decreasing antimicrobial use in dairy production. PLoS ONE 13:e0194832. doi: 10.1371/journal.pone.0194832

PubMed Abstract | Crossref Full Text | Google Scholar

Liljebjelke, K. A., Hofacre, C. L., White, D. G., Ayer, S., Lee, M. D., and Maurer, J. J. (2017). Diversity of antimicrobial resistance phenotypes in salmonella isolated from commercial poultry farms. Front. Vet. Sci. 4:96. doi: 10.3389/fvets.2017.00096

PubMed Abstract | Crossref Full Text | Google Scholar

Lone, A., Mottawea, W., Mehdi, Y., andHammami, R. (2022). Bacteriocinogenic probiotics as an integrated alternative to antibiotics in chicken production - why and how? Crit. Rev. Food Sci. Nutr. 62, 8744–8760. doi: 10.1080/10408398.2021.1932722

PubMed Abstract | Crossref Full Text | Google Scholar

Lopatkin, A. J., Meredith, H. R., Srimani, J. K., Pfeiffer, C., Durrett, R., and You, L. (2017). Persistence and reversal of plasmid-mediated antibiotic resistance. Nat. Commun. 8:1689. doi: 10.1038/s41467-017-01532-1

PubMed Abstract | Crossref Full Text | Google Scholar

Majumder, S., Jung, D., Ronholm, J., and George, S. (2021). Prevalence and mechanisms of antibiotic resistance in Escherichia coli isolated from mastitic dairy cattle in Canada. BMC Microbiol. 21:222. doi: 10.1186/s12866-021-02280-5

PubMed Abstract | Crossref Full Text | Google Scholar

Makarenkov, V., Mazoure, B., Rabusseau, G., and Legendre, P. (2021). Horizontal gene transfer and recombination analysis of SARS-CoV-2 genes helps discover its close relatives and shed light on its origin. BMC Ecol. Evolut. 21:1–18. doi: 10.1186/s12862-020-01732-2

PubMed Abstract | Crossref Full Text | Google Scholar

Mandujano, A., Cortés-Espinosa, D., Vásquez-Villanueva, J., Guel, P., Rivera, G., Juárez-Rendón, K., et al. (2023). Extended-spectrum β-lactamase-producing Escherichia coli isolated from food-producing animals in Tamaulipas, Mexico. Antibiotics 12:1010. doi: 10.3390/antibiotics12061010

PubMed Abstract | Crossref Full Text | Google Scholar

Manyi-Loh, C., Mamphweli, S., Meyer, E., and Okoh, A. (2018). Antibiotic use in agriculture and its consequential resistance in environmental sources: potential public health implications. Molecules 23:795. doi: 10.3390/molecules23040795

PubMed Abstract | Crossref Full Text | Google Scholar

Maradiaga, M., Echeverry, A., Miller, M., den Bakker, H. C., Nightingale, K., Cook, P., et al. (2019). Characterization of antimicrobial resistant (AMR) salmonella enterica isolates associated with cattle at harvest in mexico. Meat and Muscle Biol. 3:53. doi: 10.22175/mmb2017.10.0053

Crossref Full Text | Google Scholar

Martak, D., Henriot, C., and Hocquet, D. (2024). Environment, animals, and food as reservoirs of antibiotic-resistant bacteria for humans: one health or more? Infect Dis Now 54:104895. doi: 10.1016/j.idnow.2024.104895

PubMed Abstract | Crossref Full Text | Google Scholar

Martínez-Vázquez, A., Guardiola-Avila, I., and Flores-Magallón, R. (2021). Detection of multi-drug resistance and methicillin-resistant Staphylococcus aureus (MRSA) isolates from retail meat in tamaulipas, mexico. Ann. Microbiol. 71:16. doi: 10.1186/s13213-021-01627-7

Crossref Full Text | Google Scholar

Martínez-Vázquez, A., Rivera-Sanchez, G., Lira-Mendez, K., Reyes-Lopez, M.A., and Bocanegra-Garcia, V. (2018). Prevalence, antimicrobial resistance and virulence genes of escherichia coli isolated from retail meat in tamaulipas, mexico. J Glob Antimicrob Resist 14, 266–272. doi: 10.1016/j.jgar.2018.02.016

PubMed Abstract | Crossref Full Text | Google Scholar

Massé, J., Lardé, H., Fairbrother, J. M., Roy, J. P., Francoz, D., Dufour, S., et al. (2021). Prevalence of antimicrobial resistance and characteristics of Escherichia coli isolates from fecal and manure pit samples on dairy farms in the province of Quebec, Canada. Front. Vet. Sci. 8:654125. doi: 10.3389/fvets.2021.654125

PubMed Abstract | Crossref Full Text | Google Scholar

Massé, J., Vanier, G., Fairbrother, J., de Lagarde, M., Arsenault, J., Francoz, D., et al. (2023). Description of antimicrobial-resistant Escherichia coli and their dissemination mechanisms on dairy farms. Vet. Sci. 10:242. doi: 10.3390/vetsci10040242

PubMed Abstract | Crossref Full Text | Google Scholar

Mays, C., Garza, G. L., Waite-Cusic, J., Radniecki, T. S., and Navab-Daneshmand, T. (2021). Impact of biosolids amendment and wastewater effluent irrigation on enteric antibiotic-resistant bacteria - a greenhouse study. Water Res. X 13:100119. doi: 10.1016/j.wroa.2021.100119

PubMed Abstract | Crossref Full Text | Google Scholar

McCubbin, K. D., Anholt, R. M., de Jong, E., Ida, J. A., Nóbrega, D. B., Kastelic, J. P., et al. (2021). Knowledge gaps in the understanding of antimicrobial resistance in Canada. Front Public Health 9:726484. doi: 10.3389/fpubh.2021.726484

PubMed Abstract | Crossref Full Text | Google Scholar

Mehrotra, M., Li, X. Z., and Ireland, M. (2017). Enhancing antimicrobial stewardship by strengthening the veterinary drug regulatory framework. Can. Commun. Dis. Rep. 43:220–223. doi: 10.14745/ccdr.v43i11a02

PubMed Abstract | Crossref Full Text | Google Scholar

Mohsin, M., Farooq, U., Hartmann, M., Brogden, S., Kreienbrock, L., and Stoffregen, J. (2023). Case study: using a shared international database to document veterinary consumption of antibiotics in Pakistan. Antibiotics 12:394. doi: 10.3390/antibiotics12020394

PubMed Abstract | Crossref Full Text | Google Scholar

Mollenkopf, D. F., Stull, J. W., Mathys, D. A., Bowman, A. S., Feicht, S. M., Grooters, S. V., et al. (2017). Carbapenemase-producing enterobacteriaceae recovered from the environment of a swine farrow-to-finish operation in the united states. Antimicrob. Agents Chemother. 61, e01298–e01216. doi: 10.1128/AAC.01298-16

PubMed Abstract | Crossref Full Text | Google Scholar

Montoro-Dasi, L., Villagra, A., Sevilla-Navarro, S., Pérez-Gracia, M., Vega, S., and Marin, C. (2020). The dynamic of antibiotic resistance in commensal Escherichia coli throughout the growing period in broiler chickens: fast-growing vs. slow-growing breeds. Poult Sci. 10, 1591–1597. doi: 10.1016/j.psj.2019.10.080

PubMed Abstract | Crossref Full Text | Google Scholar

Mora-Hernández, Y., Vera Murguía, E., Stinenbosch, J., Hernández Jauregui, P., van Dijl, J. M., and Buist, G. (2021). Molecular typing and antimicrobial resistance profiling of 33 mastitis-related Staphylococcus aureus isolates from cows in the comarca lagunera region of mexico. Sci. Rep. 11:6912. doi: 10.1038/s41598-021-86453-2

PubMed Abstract | Crossref Full Text | Google Scholar

Moreno, M. A. (2012). Survey of quantitative antimicrobial consumption in two different pig finishing systems. Vet. Rec. 171:325. doi: 10.1136/vr.100818

PubMed Abstract | Crossref Full Text | Google Scholar

Morris, C., Wickramasingha, D., Abdelfattah, E., Pereira, R., Okello, E., and Maier, G. (2023). Prevalence of antimicrobial resistance in fecal Escherichia coli and enterococcus spp. isolates from beef cow-calf operations in northern california and associations with farm practices. Front. Microbiol. 14:1086203. doi: 10.3389/fmicb.2023.1086203

PubMed Abstract | Crossref Full Text | Google Scholar

Mujahid, S., Hansen, M., Miranda, R., Newsom-Stewart, K., and Rogers, J. E. (2023). Prevalence and antibiotic resistance of salmonella and campylobacter isolates from raw chicken breasts in retail markets in the united states and comparison to data from the plant level. Life 13:642. doi: 10.3390/life13030642

PubMed Abstract | Crossref Full Text | Google Scholar

Murray, R., Tien, Y. C., Scott, A., and Topp, E. (2019). The impact of municipal sewage sludge stabilization processes on the abundance, field persistence, and transmission of antibiotic resistant bacteria and antibiotic resistance genes to vegetables at harvest. Sci. Total Environ. 651, 680–1687. doi: 10.1016/j.scitotenv.2018.10.030

PubMed Abstract | Crossref Full Text | Google Scholar

Narvaez-Bravo C. Taboada E. Mutschall S. and M. A. (2017). Epidemiology of antimicrobial resistant Campylobacter spp. isolated from retail meats in Canada. Int. J. Food Microbiol. 253, 43–47. doi: 10.1016/j.ijfoodmicro.2017.04.019

PubMed Abstract | Crossref Full Text | Google Scholar

Nathan, C. (2020). Resisting antimicrobial resistance. Nat. Rev. Microbiol. 18:259–260. doi: 10.1038/s41579-020-0348-5

PubMed Abstract | Crossref Full Text | Google Scholar

Naushad, S., Nobrega, D., Naqvi, S., Barkema, H., and De Buck, J. (2020). Genomic analysis of bovine Staphylococcus aureus isolates from milk to elucidate diversity and determine the distributions of antimicrobial and virulence genes and their association with mastitis. mSystems 5, e00063–e00020. doi: 10.1128/mSystems.00063-20

PubMed Abstract | Crossref Full Text | Google Scholar

Nicholson, T., and Bayles, D. (2022). Comparative virulence and antimicrobial resistance distribution of Streptococcus suis isolates obtained from the united states. Front. Microbiol. 13:1043529. doi: 10.3389/fmicb.2022.1043529

PubMed Abstract | Crossref Full Text | Google Scholar

Nobrega, D., De Buck, J., and Barkema, H. (2018a). Antimicrobial resistance in non-aureus staphylococci isolated from milk is associated with systemic but not intramammary administration of antimicrobials in dairy cattle. J. Dairy Sci. 101:7425–7436. doi: 10.3168/jds.2018-14540

PubMed Abstract | Crossref Full Text | Google Scholar

Nobrega, D., Naushad, S., Naqvi, S., Condas, L., Saini, V., and Kastelic, J. P. (2018b). Prevalence and genetic basis of antimicrobial resistance in non-aureus staphylococci isolated from Canadian dairy herds. Front. Microbiol. 8:256. doi: 10.3389/fmicb.2018.00256

PubMed Abstract | Crossref Full Text | Google Scholar

Nova Nayarit-Ballesteros, M., María Salud Rubio-Lozano, D., Enrique Delgado-Suárez, M., Danilo Méndez-Medina, D., Diego Braña-Varela, D., and Oscar Rodas-Suárez, D. (2016). Perfil de resistencia a antibióticos de serotipos de salmonella spp. aislados de carne de res molida en la ciudad de méxico. Salud Pública De México 58, 371–377. doi: 10.21149/spm.v58i3.7897

PubMed Abstract | Crossref Full Text | Google Scholar

Novoa Rama, E., Bailey, M., and Jones, D. (2018). Prevalence, persistence, and antimicrobial resistance of campylobacter spp. from eggs and laying hens housed in five commercial housing systems. Foodborne Pathog. Dis. 15, 506–516. doi: 10.1089/fpd.2017.2404

PubMed Abstract | Crossref Full Text | Google Scholar

O'Neill, J. (2016). Review on Antimicrobial Resistance: Tackling Drug-Resistant Infections Globally: Final Report and Recommendations. The Wellcome Trust and the UK Department of Health.

Google Scholar

Otto, S., Haworth-Brockman, M., Miazga-Rodriguez, M., Wierzbowski, A., and Saxinger, L. (2022). Integrated surveillance of antimicrobial resistance and antimicrobial use: evaluation of the status in Canada (2014-2019). Can. Vet. J. 63, 161–170. doi: 10.17269/s41997-021-00600-w

PubMed Abstract | Crossref Full Text | Google Scholar

Park, J., Friendship, R. M., Poljak, Z., Weese, J. S., and Dewey, C. E. (2013). An investigation of exudative epidermitis (greasy pig disease) and antimicrobial resistance patterns of staphylococcus hyicus and Staphylococcus aureus isolated from clinical cases. Can. Vet. J. 54, 139–144.

PubMed Abstract | Google Scholar

Paulson J. A. Zaoutis T. E. Council on Environmental Health. (2015). Nontherapeutic use of antimicrobial agents in animal agriculture: Implications for pediatrics. Pediatrics 136, e1670–e1677. doi: 10.1542/peds.2015-3630

PubMed Abstract | Crossref Full Text | Google Scholar

Pinto, C. E., Keestra, S. M., Tandon, P., Pickering, A. J., Moodley, A., Cumming, O., et al. (2023). One health wash: an AMR-smart integrative approach to preventing and controlling infection in farming communities. BMJ Global Health 8:e011263. doi: 10.1136/bmjgh-2022-011263

PubMed Abstract | Crossref Full Text | Google Scholar

Pires, J., Huisman, J., Bonhoeffer, S., and Van Boeckel, T. (2021). Multidrug resistance dynamics in salmonella in food animals in the united states: an analysis of genomes from public databases. Microbiol. Spectr. 16:e0049521. doi: 10.1128/Spectrum.00495-21

PubMed Abstract | Crossref Full Text | Google Scholar

Pornsukarom, S., and Thakur, S. (2016). Assessing the impact of manure application in commercial swine farms on the transmission of antimicrobial resistant salmonella in the environment. PLoS ONE 11:e0164621. doi: 10.1371/journal.pone.0164621

PubMed Abstract | Crossref Full Text | Google Scholar

Pourabedin, M., and Zhao, X. (2015). Prebiotics and gut microbiota in chickens. FEMS Microbiol. Lett. 362:fnv122. doi: 10.1093/femsle/fnv122

PubMed Abstract | Crossref Full Text | Google Scholar

Prescott, J. (2017). “History and current use of antimicrobial drugs in veterinary medicine,” in Antimicrobial Resistance in Bacteria from Livestock and Companion Animals, eds. F. Aarestrup, S. Schwarz, J. Shen, and L. Cavaco (Washington, D.C.: ASM Press).

Google Scholar

Qian, X., Gu, J., Sun, W., Wang, X. J., Su, J. Q., and Stedfeld, R. (2018). Diversity, abundance, and persistence of antibiotic resistance genes in various types of animal manure following industrial composting. J. Hazard. Mater 344:716–722. doi: 10.1016/j.jhazmat.2017.11.020

PubMed Abstract | Crossref Full Text | Google Scholar

Rahman, M., Alam, M. U., Luies, S. K., Kamal, A., Ferdous, S., Lin, A., et al. (2021). Contamination of fresh produce with antibiotic-resistant bacteria and associated risks to human health: a scoping review. Int. J. Environ. Res. Public Health 19:360. doi: 10.3390/ijerph19010360

PubMed Abstract | Crossref Full Text | Google Scholar

Rama, E. N., Bailey, M., Kumar, S., Leone, C., Bakker, H. C., et al. (2022). Prevalence and antimicrobial resistance of salmonella in conventional and no antibiotics ever broiler farms in the united states. Food Cont.135:108738. doi: 10.1016/j.foodcont.2021.108738

PubMed Abstract | Crossref Full Text | Google Scholar

Randad, P., Larsen, J., Kaya, H., Pisanic, N., Ordak, C., Price, L., et al. (2021). Transmission of antimicrobial-resistant Staphylococcus aureus clonal complex 9 between pigs and humans, united states. Emerging Infect. Dis. 27, 740–748. doi: 10.3201/eid2703.191775

PubMed Abstract | Crossref Full Text | Google Scholar

Rao, S., Linke, L., Magnuson, R., Jauch, L., and Hyatt, D. (2021). Antimicrobial resistance and interspecies gene transfer in Campylobacter coli and Campylobacter jejuni isolated from food animals, poultry processing, and retail meat in north carolina, 2018-2019. PLoS ONE 16:e0246571.

PubMed Abstract | Google Scholar

Redding, L. E., Habing, G. G., Tu, V., Bittinger, K. L., O'Day, J., Pancholi, P., et al. (2023). Infrequent intrahousehold transmission of Clostridioides difficile between pet owners and their pets. Zoonoses Public Health 10, 1–10. doi: 10.1111/zph.13032

PubMed Abstract | Crossref Full Text | Google Scholar

Rhouma, M., Tessier, M., Aenishaenslin, C., Sanders, P., and Carabin, H. (2021). Should the increased awareness of the one health approach brought by the Covid-19 pandemic be used to further tackle the challenge of antimicrobial resistance? Antibiotics 10:464. doi: 10.3390/antibiotics10040464

PubMed Abstract | Crossref Full Text | Google Scholar

Ribeiro, L. F., Nespolo, N. M., Rossi, G., and Fairbrother, M. J. (2024). Exploring extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in food-producing animals and animal-derived foods. Pathogens 13:346. doi: 10.3390/pathogens13040346

PubMed Abstract | Crossref Full Text | Google Scholar

Rima, M., Rima, M., Fajloun, Z., Sabatier, J. M., Bechinger, B., and Naas, T. (2021). Antimicrobial peptides: a potent alternative to antibiotics. Antibiotics (Basel) 10:1095. doi: 10.3390/antibiotics10091095

PubMed Abstract | Crossref Full Text | Google Scholar

Rodríguez-Medina, N., Barrios-Camacho, H., Duran-Bedolla, J., and Garza-Ramos, U. (2019). Klebsiella variicola: an emerging pathogen in humans. Emerg. Microbes Infect. 8, 973–988. doi: 10.1080/22221751.2019.1634981

PubMed Abstract | Crossref Full Text | Google Scholar

Roken, M., Forfang, K., Wasteson, Y., Haaland, A. H., Eiken, H. G., Hagen, S. B., et al. (2022). Antimicrobial resistance-do we share more than companionship with our dogs? J. Appl. Microbiol. 133, 1027–1039. doi: 10.1111/jam.15629

PubMed Abstract | Crossref Full Text | Google Scholar

Romero Barrios, P., Deckert, A., Parmley, E. J., and Leclair, D. (2020). Antimicrobial resistance profiles of Escherichia coli and salmonella isolates in Canadian broiler chickens and their products. Foodborne Pathog. Dis. 17, 672–678. doi: 10.1089/fpd.2019.2776

PubMed Abstract | Crossref Full Text | Google Scholar

Rortveit, G., and Simonsen, G. (2020). The primary care perspective on the Norwegian national strategy against antimicrobial resistance. Antibiotics 9:622. doi: 10.3390/antibiotics9090622

PubMed Abstract | Crossref Full Text | Google Scholar

rudzynski, K., and S. C. (2015). Honey glycoproteins containing antimicrobial peptides, jelleins of the major royal jelly protein 1, are responsible for the cell wall lytic and bactericidal activities of honey. PLoS ONE 10:e0120238. doi: 10.1371/journal.pone.0120238

PubMed Abstract | Crossref Full Text | Google Scholar

Salaheen, S., Cao, H., Sonnier, J., Kim, S., Del Collo, L., Hovingh, E., et al. (2019). Diversity of extended-spectrum cephalosporin-resistant Escherichia coli in feces from calves and cows on pennsylvania dairy farms. Foodborne Pathog. Dis. 16, 368–370. doi: 10.1089/fpd.2018.2579

PubMed Abstract | Crossref Full Text | Google Scholar

Salam, M. A., Al-Amin, M. Y., Salam, M. T., Pawar, J. S., Akhter, N., Rabaan, A. A., et al. (2023). Antimicrobial resistance: a growing serious threat for global public health. Healthcare 11:1946. doi: 10.3390/healthcare11131946

PubMed Abstract | Crossref Full Text | Google Scholar

Salgado-Ruiz, T. B., Rodríguez, A., Gutiérrez, D., Martínez, B., García, P., Espinoza-Ortega, A., et al. (2015). Molecular characterization and antimicrobial susceptibility of Staphylococcus aureus from small-scale dairy systems in the highlands of Central México. Dairy Sci. Technol. 95, 181–196. doi: 10.1007/s13594-014-0195-0

Crossref Full Text | Google Scholar

Sancheza, H. M., Echeverria, C., Thulsiraj, V., Faust, A. Z., Flores, A., Laitz, M., et al. (2016). Antibiotic resistance in airborne bacteria near conventional and organic beef cattle farms in California, USA. Water Air Soil Pollut. 227:280. doi: 10.1007/s11270-016-2979-8

Crossref Full Text | Google Scholar

Sapkota, A. R., Lefferts, L. Y., McKenzie, S., and Walker, P. (2007). What do we feed to food-production animals? A review of animal feed ingredients and their potential impacts on human health. Environ. Health Perspect. 115, 663–670. doi: 10.1289/ehp.9760

PubMed Abstract | Crossref Full Text | Google Scholar

Schwarz, S., Loeffler, A., and Kadlec, K. (2017). Bacterial resistance to antimicrobial agents and its impact on veterinary and human medicine. Vet. Dermatol. 28, 82–e19. doi: 10.1111/vde.12362

PubMed Abstract | Crossref Full Text | Google Scholar

Scott, A., Tien, Y. C., Drury, C. F., Reynolds, W. D., and Topp, E. (2018). Enrichment of antibiotic resistance genes in soil receiving composts derived from swine manure, yard wastes, or food wastes, and evidence for multiyear persistence of swine Clostridium spp. Can. J. Microbiol. 64, 201–208. doi: 10.1139/cjm-2017-0642

PubMed Abstract | Crossref Full Text | Google Scholar

Shrestha, R., Agunos, A., Gow, S., Deckert, A., and Varga, C. (2022). Associations between antimicrobial resistance in fecal Escherichia coli isolates and antimicrobial use in Canadian turkey flocks. Front. Microbiol. 29:954123. doi: 10.3389/fmicb.2022.954123

PubMed Abstract | Crossref Full Text | Google Scholar

Sibbald, B. (2012). Farm-grown superbugs: while the world acts, Canada dawdles. CMAJ 184:1553. doi: 10.1503/cmaj.120561

PubMed Abstract | Crossref Full Text | Google Scholar

Smith, O. M., Snyder, W. E., and Owen, J. P. (2020). Are we overestimating risk of enteric pathogen spillover from wild birds to humans? Biol. Rev. Camb. Philos. Soc. 95:95. doi: 10.1111/brv.12581

PubMed Abstract | Crossref Full Text | Google Scholar

Sodagari, H., and Varga, C. (2023). Evaluating antimicrobial resistance trends in commensal Escherichia coli isolated from cecal samples of swine at slaughter in the United States, 2013-2019. Microorganisms 11:1033. doi: 10.3390/microorganisms11041033

PubMed Abstract | Crossref Full Text | Google Scholar

Sodagari, H., Varga, C., Habib, I., and Sahibzada, S. (2023). Comparison of antimicrobial resistance among commensal Escherichia coli isolated from retail table eggs produced by laying hens from the cage and non-cage housing systems in Western Australia. Antibiotics 12:588. doi: 10.3390/antibiotics12030588

PubMed Abstract | Crossref Full Text | Google Scholar

Srednik, M. E., Lantz, K., Hicks, J. A., R, M.-S. B., Mackie, T. A., and Schlater, L. K. (2021). Antimicrobial resistance and genomic characterization of salmonella dublin isolates in cattle from the united states. PLoS ONE 16:e0249617. doi: 10.1371/journal.pone.0249617

PubMed Abstract | Crossref Full Text | Google Scholar

Surveillance de l'antibiorésistance-Rapport Annuel (2011). Available online at: www.agrireseau.net/documents/8528

Google Scholar

Talavera-González, J. M., Talavera-Rojas, M., Soriano-Vargas, E., Vázquez-Navarrete, J., and Salgado-Miranda, J. (2021). In vitro transduction of antimicrobial resistance genes into Escherichia coli isolates from backyard poultry in Mexico. Can. J. Microbiol. 67, 415–425. doi: 10.1139/cjm-2020-0280

PubMed Abstract | Crossref Full Text | Google Scholar

Tang, Y., Fang, L., C, X., and Zhang, Q. (2017a). Antibiotic resistance trends and mechanisms in the foodborne pathogen, Campylobacter. Anim. Health Res. Rev. 18, 87–98. doi: 10.1017/S1466252317000135

PubMed Abstract | Crossref Full Text | Google Scholar

Tang, Y., Sahin, O., Pavlovic, N., LeJeune, J., Carlson, J., Wu, Z., et al. (2017b). Rising fluoroquinolone resistance in campylobacter isolated from feedlot cattle in the united state. Sci. Rep. 7:494. doi: 10.1038/s41598-017-00584-z

PubMed Abstract | Crossref Full Text | Google Scholar

Tate, H., Li, C., Nyirabahizi, E., Tyson, G., Zhao, S., Rice-Trujillo, C., et al. (2021). A national antimicrobial resistance monitoring system survey of antimicrobial-resistant foodborne bacteria isolated from retail veal in the United States. J. Food Prot. 84, 1749–1759. doi: 10.4315/JFP-21-005

PubMed Abstract | Crossref Full Text | Google Scholar

Thakur, S., and Gray, G. C. (2019). The mandate for a global "one health" approach to antimicrobial resistance surveillance. Am. J. Trop. Med. Hyg. 100, 227–228. doi: 10.4269/ajtmh.18-0973

PubMed Abstract | Crossref Full Text | Google Scholar

Trends in Veterinary Antibiotic Use in the Netherlands 2005-2011 (2011). Available online at: edepot.wur.nl/214172

Google Scholar

Van Boeckel, T. P., Brower, C., Gilbert, M., Grenfell, B. T., Levin, S. A., Robinson, T. P., et al. (2015). Global trends in antimicrobial use in food animals. Proc. Natl. Acad. Sci. 112, 5649–5654. doi: 10.1073/pnas.1503141112

PubMed Abstract | Crossref Full Text | Google Scholar

Varela-Ortiz, D. F., Barboza-Corona, J. E., González-Marrero, J., León-Galván, M. F., Valencia-Posadas, M., Lechuga-Arana, A. A., et al. (2018). Antibiotic susceptibility of Staphylococcus aureus isolated from subclinical bovine mastitis cases and in vitro efficacy of bacteriophage. Vet. Res. Commun. 42, 243–250. doi: 10.1007/s11259-018-9730-4

PubMed Abstract | Crossref Full Text | Google Scholar

Varga, C., Brash, M., Slavic, D., Boerlin, P., Ouckama, R., Weis, A., et al. (2018). Evaluating virulence-associated genes and antimicrobial resistance of avian pathogenic Escherichia coli isolates from broiler and broiler breeder chickens in Ontario, Canada. Avian Dis. 62, 291–299. doi: 10.1637/11834-032818-Reg.1

PubMed Abstract | Crossref Full Text | Google Scholar

Varga, C., Guerin, M. T., Bras, M. L., Slavic, D., Boerlin, P., and Susta, L. (2019). Antimicrobial resistance in fecal Escherichia coli and salmonella enterica isolates: a two-year prospective study of small poultry flocks in Ontario, Canada. BMC Vet. Res. 2019:464. doi: 10.1186/s12917-019-2187-z

PubMed Abstract | Crossref Full Text | Google Scholar

Vega-Sánchez, V., Barba-León, J., González-Aguilar, D., Cabrera-Díaz, E., Pacheco-Gallardo, C., and Orozco-García, A. (2020). Resistencia antimicrobiana de Salmonella spp aisladas de canales de cerdo obtenidas de dos tipos de rastros en Jalisco, México. Rev Mex CiencPecu 11, 1004–1015. doi: 10.22319/rmcp.v11i4.5386

Crossref Full Text | Google Scholar

Velasquez, C., Macklin, K. S., Kumar, S., Bailey, M., Ebner, P. E., Oliver, H. F., et al. (2018). Prevalence and antimicrobial resistance patterns of salmonella isolated from poultry farms in southeastern united states. Poult. Sci. 97, 2144–2152. doi: 10.3382/ps/pex449

PubMed Abstract | Crossref Full Text | Google Scholar

Ventola, C. L. (2015). The antibiotic resistance crisis: part 1: causes and threats. P T 40, 277–283.

Google Scholar

Vounba, P., Arsenault, J., Bada-Alambédji, R., and Fairbrother, J. (2019). Antimicrobial resistance and potential pathogenicity of Escherichia coli isolates from healthy broilers in Québec, Canada. Microb. Drug Resist. 25, 1111–1121. doi: 10.1089/mdr.2018.0403

PubMed Abstract | Crossref Full Text | Google Scholar

Waldner, C., Gow, S., Parker, S., and Campbell, J. (2019). Antimicrobial resistance in fecal Escherichia coli and Campylobacter spp. from beef cows in western Canada and associations with herd attributes and antimicrobial use. Can. J. Vet. Res. 83, 80–89.

PubMed Abstract | Google Scholar

Weese, J. S., Archambault, M., Willey, B. M., Hearn, P., Kreiswirth, B. N., Said-Salim, B., et al. (2005). Methicillin-resistant Staphylococcus aureus in horses and horse personnel, 2000-2002. Emerging Infect. Dis. 11, 430–435. doi: 10.3201/eid1103.040481

PubMed Abstract | Crossref Full Text | Google Scholar

Williams-Nguyen, J., Sallach, J. B., Bartelt-Hunt, S., Boxall, A. B., Durso, L. M., McLain, J. E., et al. (2016). Antibiotics and antibiotic resistance in agroecosystems: State of the science. J. Environ. Qual. 45, 394–406. doi: 10.2134/jeq2015.07.0336

PubMed Abstract | Crossref Full Text | Google Scholar

World Health Organization. (2012). World Health Organization: The Evolving Threat of Antimicrobial Resistance: Options for Action. Available online at: apps.who.int/iris/handle/10665/75389

PubMed Abstract | Google Scholar

Wu, R. A., Feng, J. Y., Liu, D., and Ding, T. (2023). Overuse of food-grade disinfectants threatens a global spread of antimicrobial-resistant bacteria. Crit. Rev. Food Sci. Nutr. 64, 6870–6879. doi: 10.1080/10408398.2023.2176814

PubMed Abstract | Crossref Full Text | Google Scholar

Xu, C., Kong, L., Gao, H., Cheng, X., and Wang, X. (2022). A review of current bacterial resistance to antibiotics in food animals. Front. Microbiol. 13:822689. doi: 10.3389/fmicb.2022.822689

PubMed Abstract | Crossref Full Text | Google Scholar

Xu, S., Sura, S., Zaheer, R., Wang, G., Smith, A., Cook, S., et al. (2016). Dissipation of antimicrobial resistance determinants in composted and stockpiled beef cattle manure. J. Environ. Qual. 45, 528–536. doi: 10.2134/jeq2015.03.0146

PubMed Abstract | Crossref Full Text | Google Scholar

Yang, Y., Ashworth, A. J., Willett, C., Cook, K., Upadhyay, A., Owens, P. R., et al. (2019). Review of antibiotic resistance, ecology, dissemination, and mitigation in U.S. broiler poultry systems. Front. Microbiol. 10:2639. doi: 10.3389/fmicb.2019.02639

PubMed Abstract | Crossref Full Text | Google Scholar

Yaqoob, M. U., Wang, G., and Wang, M. (2022). An updated review on probiotics as an alternative of antibiotics in poultry - a review. Anim. Biosci. 35, 1109–1120. doi: 10.5713/ab.21.0485

PubMed Abstract | Crossref Full Text | Google Scholar

Yuan, Q. B., Guo, M. T., and Yang, J. (2015). Fate of antibiotic resistant bacteria and genes during wastewater chlorination: implication for antibiotic resistance control. PLoS ONE 10:e0119403. doi: 10.1371/journal.pone.0119403

PubMed Abstract | Crossref Full Text | Google Scholar

Zaheer, R., Cook, S. R., an Barbieri, R., Goji, N., Cameron, A., Petkau, A., et al. (2020). Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a one-health continuum. Sci. Rep. 10:3937. doi: 10.1038/s41598-020-61002-5

PubMed Abstract | Crossref Full Text | Google Scholar

Zaheer, R., Lakin, S. M., Polo, R. O., Cook, S. R., Larney, F. J., Morley, P. S., et al. (2019). Comparative diversity of microbiomes and resistomes in beef feedlots, downstream environments and urban sewage influent. BMC Microbiol. 19:197. doi: 10.1186/s12866-019-1548-x

PubMed Abstract | Crossref Full Text | Google Scholar

Zaidi, M. B., Dreser, A., and Figueroa, I. M. (2015). A collaborative initiative for the containment of antimicrobial resistance in mexico. Zoonoses Public Health 62, 52–57 doi: 10.1111/zph.12166

PubMed Abstract | Crossref Full Text | Google Scholar

Keywords: antibiotics, antimicrobial use, antimicrobial resistance, farm animals, food-producing animals, North America

Citation: Mediouni M, Diallo AB and Makarenkov V (2025) Quantifying antimicrobial resistance in food-producing animals in North America. Front. Microbiol. 16:1542472. doi: 10.3389/fmicb.2025.1542472

Received: 09 December 2024; Accepted: 01 May 2025;
Published: 27 May 2025.

Edited by:

Fohad Mabood Husain, King Saud University, Saudi Arabia

Reviewed by:

Mohammad Tahir Siddiqui, Indian Institute of Technology Delhi, India
Rachel Amanda Hickman, Independent researcher, Uppsala, Sweden

Copyright © 2025 Mediouni, Diallo and Makarenkov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Mohamed Mediouni, bWVkaW91bmkubW9oYW1lZEBjb3Vycmllci51cWFtLmNh

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