ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Food Microbiology
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1550913
This article is part of the Research TopicProbiotics for Global Health: Advances, Applications and ChallengesView all 24 articles
Disclosing the benefits of multi-strain compounds and their health impact mechanisms utilizing intestinal biomimetic technology
Provisionally accepted
- 1Zhejiang Academy of Agricultural Sciences, Hangzhou, China
- 2Shanxi Agricultural University, Jinzhong, Shanxi Province, China
- 3Shanxi Key Laboratory of Animal Genetics Resource Utilization and Breeding, Taigu, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The gut microbiota plays a vital function in preserving intestinal homeostasis and general health. This study examined the impacts of a composite probiotic based on an in vitro fermentation system and an organoid interaction research platform to investigate the effects of composite probiotics. 4P, investigating the impact of gut barrier function through the utilization of in vitro and organoid models. Our findings revealed that 4P demonstrated excellent capabilities for producing short-chain fatty acids, modulating intestinal gas metabolism, and regulating oxidative-reduction potential. Furthermore, the individual strains that comprise 4P were selected for subsequent organoid studies based on previous in vitro strain culture experiments. Our results suggest that 4P and its individual strains hold promise for preserving the gut barrier integrity and function, thereby potentially offering therapeutic benefits in the context of intestinal disorders. These findings underscore the importance of exploring the mechanistic actions of composite probiotics in maintaining gut health and preventing diseases.
Keywords: Composite probiotics, in vitro culture, Organoids, intestinal barrier, anti-inflammatory
Received: 24 Dec 2024; Accepted: 25 Apr 2025.
Copyright: © 2025 Liao, Huang, Li, Kuang, Li, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Weiwei Wang, Shanxi Agricultural University, Jinzhong, Shanxi Province, China
Jinjun Li, Zhejiang Academy of Agricultural Sciences, Hangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.