REVIEW article
Front. Microbiol.
Sec. Systems Microbiology
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1551515
Intratumoral microbiota: implications for cancer progression and treatment
Provisionally accepted
- First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, China
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The human body has a diverse range of microbiota that influences human physiological processes and alters disease risk, involving cancer. Metagenomic sequencing investigations have revealed that the microbiota is an element of the tumor microenvironment, affecting tumor proliferation and responsiveness to current anticancer treatments. The notion of intratumoral microbiota was subsequently introduced. Intratumoral microorganisms have been identified in kinds of cancer, including pancreatic, colorectal, liver, esophageal, breast, and lung malignancies.Microbiota may inhabit tumor tissues by mucosal breakdown, neighboring tissue migration, and hematogenous spread, influencing the biological behavior of tumors as a significant component of tumor's microenvironment. The intratumoral microbiota may facilitate the onset and progression of malignancies through DNA mutations, activation of carcinogenic pathways, alteration of anticancer medication metabolism,
Keywords: Conceptualization, Methodology, Software, Investigation, Formal Analysis, Writing-Original Draft, Zhenguo Wu: Data Curation, Writing-Original Draft, Yan Liu: Visualization, Investigation, Yu Gu: Resources, Supervision, Jiahao Niu: Software, Validation, Kun Lv (Corresponding Author): Conceptualization, Funding Acquisition, Resources, Supervision, Writing-Review& Editing Intratumoral microbiota, Tumorigenesis, Therapy for anticancer, Biomarker, Drug metabolism
Received: 14 Jan 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Xie, Wu, Liu, Gu, Niu and Lv. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Kun Lv, First Affiliated Hospital of Wannan Medical College, Wuhu, 241001, Anhui Province, China
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