ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Food Microbiology
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1553399
This article is part of the Research TopicAssessment and Application of Microbial Additives in Unconventional Feeds FermentationView all 9 articles
Efficient utilization of Shuanghuanglian medicine residues by microbial transformation with flavonoid glycosides-hydrolyzing strains
Provisionally accepted
Xingwang Ma1Ying Chen1Lili Li1
Tianwei Wang1
Kunling Teng1Junchang Su1Lei Li2Liangliang Li2Heping Li3Wentao Diao2Guocan Chen2Jiwen Wang2*
Jin Zhong1*- 1State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China
- 2Institute of Biology Co., Ltd., Henan Academy of Sciences, Zhengzhou, China
- 3College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China
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Shuanghuanglian, a traditional Chinese medicine, is well-known for its bioactive compounds, such as flavonoids, which offer significant health benefits. However, the production of Shuanghuanlian generates substantial pharmaceutical residues, which are often discarded as waste, posing significant environmental and economic challenges.To date, research on repurposing these medicine residues has been limited. This study utilized beneficial microbes to efficiently extract and utilize the residual bioactive compounds. Notably, a newly isolated Lactiplantibacillus plantarum strain LLB exhibited remarkable efficiency in converting flavonoid glycosides (e.g., phillyrin and luteoloside) into their corresponding aglycones. When combined synergistically with Bacillus subtilis and Saccharomyces cerevisiae, strain LLB maintained robust flavonoid glycoside conversion while enhancing lactobacilli viability in the fermented medicine residues. As a feed additive for broiler chickens, the fermented residue not only boosted antioxidant (superoxide dismutase) and anti-inflammatory (IL-10) markers, but also preserved growth performance and meat quality. Furthermore, the fermented residue modulated the gut microbiome, increasing Rikenella while reducing Elusimicrobiota and Parabacteroides abundances. Our findings demonstrate that microbial transformation of Shuanghuanglian residues offers a sustainable strategy for waste valorization and a novel feed additive for enhancing animal health.
Keywords: Chinese medicine residue, Flavonoid, lactiplantibacillus plantarum, feed additive, intestinal microbiota
Received: 30 Dec 2024; Accepted: 06 May 2025.
Copyright: © 2025 Ma, Chen, Li, Wang, Teng, Su, Li, Li, Li, Diao, Chen, Wang and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiwen Wang, Institute of Biology Co., Ltd., Henan Academy of Sciences, Zhengzhou, China
Jin Zhong, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China
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