ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1567132
This article is part of the Research TopicEmerging Pathogens and Contaminants in the Environment: Human Health Risks, Exposure Pathways and Epidemiological OutcomesView all 11 articles
Detection of IgG antibody against the porcine norovirus GII.11 in human, domestic and wild animals
Provisionally accepted
Jiayi Xu
Huisha DuJunxuan YuRuojun WuQianxin Lu
Xin JiangBingwen ZengTianhui Li
Qing Chen*
Yingchun Dai*- Southern Medical University, Guangzhou, China
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Zoonotic diseases pose a critical threat to global public health, with noroviruses (NoVs) increasingly recognized for their potential to cross species barriers. Traditionally, NoVs were considered hostspecific; however, recent evidence suggests the possibility of interspecies transmission. This study investigates the zoonotic potential of porcine NoV (PorNoV) genotype GII.11, which shares high genetic similarity with human NoVs (HuNoVs), by detecting GII.11-specific IgG antibodies in humans and various animals using a Luciferase Immunosorbent Assay (LISA). Seroprevalence was observed in humans (15.2%), pigs (49.3%), dogs (30.6%), wild rats (9.5%), and bats (65.1%), marking the first detection of GII.11 PorNoV antibodies in humans and non-swine species. Bats exhibited the highest seropositivity and antibody levels (vs. humans [P=0.0011] and pigs [P=0.0164]), suggesting their potential role as reservoirs. These findings provide serological evidence for anthropozoonotic transmission, challenging the paradigm of strict host specificity in NoVs. Enhanced surveillance of PorNoV in animal reservoirs and high-risk human populations is needed to mitigate zoonotic spillover risks. Further research should aim to elucidate mechanisms of transmission and the clinical significance of cross-species NoVs exposure.
Keywords: GII.11 norovirus, LISA, Anthropozoonosis, cross-species transmission, porcine norovirus
Received: 26 Jan 2025; Accepted: 26 May 2025.
Copyright: © 2025 Xu, Du, Yu, Wu, Lu, Jiang, Zeng, Li, Chen and Dai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qing Chen, Southern Medical University, Guangzhou, China
Yingchun Dai, Southern Medical University, Guangzhou, China
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