ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1578903
This article is part of the Research TopicBioinformatics approaches to investigate antimicrobial resistance (AMR) in human, animal and environmentView all 17 articles
Deciphering Vancomycin Resistance in Enterococcus faecium: Gene Distribution, Sequence Typing, and Global Phylogenetic Analysis
Provisionally accepted
- Department of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Jiangsu, China, Nanjing Drum Tower Hospital, Nanjing, China
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Objective: This study analyzes the global prevalence and distribution of vancomycin resistance genes (van) in Enterococcus faecium and examines the genetic relationship and epidemiological characteristics of strains carrying these genes.Method: A total of 3256 E. faecium genome sequences were downloaded, and 2235 high-quality genomes were retained after quality filtering. The blastn tool was used to screen these genomes for van genes, and sequence types (STs) were determined using pubMLST profiles.Result: Among the 2235 genomes, 1071 (47.9%) harbored van genes, with eight genotypes identified, including vanA, vanB, vanD, and vanM, accounting for 47.6%. There were 83 distinct STs among the strains carrying van genes, with ST17 being the most prevalent. Most strains carrying van genes were isolated from humans, primarily in the United States, and commonly from rectal swabs.In 2015, vanA was the most prevalent van gene, particularly in ST17 strains.This study highlights the widespread distribution of van genes and their significant presence in human populations and clinical settings, emphasizing the importance of monitoring and intervening in the spread of ST17 strains.
Keywords: Xiaoli Cao, Senior technician E. faecium, van, Sequence types, phylogenetic tree, Prevalence characteristics
Received: 18 Feb 2025; Accepted: 31 Jul 2025.
Copyright: © 2025 Yan, Ji, Shen and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoli Cao, Department of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Jiangsu, China, Nanjing Drum Tower Hospital, Nanjing, China
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