SYSTEMATIC REVIEW article
Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1583520
This article is part of the Research TopicExpanded Genus Brucella: from Taxonomy to Clinical Manifestations and Diagnosis ChallengesView all 10 articles
Mapping the Research Landscape of Immune Response in Human Brucellosis: A Bibliometric Analysis
Provisionally accepted
- People’s Hospital of Xinjiang Uygur Autonomous Region, Clinical Laboratory Center, Urumqi, China
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Brucella bacteria are adept at evading the human immune system, leading to a chronic infectious disease known as brucellosis, which poses significant global health challenges. This study addresses the notable gap in bibliometric analyses concerning the immune response to brucellosis. Utilizing a comprehensive literature screening from the Web of Science Core Collection (1980-2024) and employing R software, VOSviewer, and CiteSpace, we analyzed 733 publications, revealing an average annual growth rate of 5.91%. The United States was the leading contributor in terms of publication volume and citations, followed by China and France, with INSERM (France) and CONICET (Argentina) recognized as prominent research institutions. The journal Infection and Immunity was a leading publication in the field, with 97 papers published and 5,184 citations. Keyword co-occurrence analysis identified three main clusters: Brucella vaccine development and immune protection, Brucella molecular mechanisms and intracellular survival strategies, and host innate immunity and Brucella interaction mechanisms. Burst analysis revealed that since 2018, keywords such as “protection”, “type IV secretion system”, “pathogenesis”, and “prediction” gained significant attention. This bibliometric analysis sheds light on the global research landscape regarding immune response in human brucellosis, pinpointing trends and gaps, with a focus on immune escape mechanisms and the future development of safe, effective vaccines.
Keywords: Brucellosis Immunity: Bibliometric Trends Human brucellosis, immune response, bibliometric analysis, type IV secretion system, vaccine development
Received: 16 Apr 2025; Accepted: 04 Jul 2025.
Copyright: © 2025 Wang, Lu, Wang, Song, Tong, Yang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhiwei Li, People’s Hospital of Xinjiang Uygur Autonomous Region, Clinical Laboratory Center, Urumqi, China
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