SYSTEMATIC REVIEW article
Front. Microbiol.
Sec. Systems Microbiology
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1589331
This article is part of the Research TopicExploring the Oral-Gut Microbiome Interactions: Pathways to Therapeutic Strategies and Implications for Systemic HealthView all 14 articles
Bibliometric and Visualized Analysis of the Relationship Between Rheumatoid Arthritis and Periodontitis-Related Bacteria Using CiteSpace Software
Provisionally accepted
- 1The Third Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China
- 2The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China
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Background: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease of unknown etiology. Recent studies have indicated a potential relationship between the oral microbiome and the onset and progression of RA. However, research trends in this area have not been comprehensively examined. The aim of this study was to conduct a bibliometric analysis of the relationship between RA and the oral microbiome from January 1, 1995, to January 10, 2024, to elucidate the research landscape, including hot topics and emerging trends.We extracted literature related to RA and the oral microbiome from the Web of Science database. Utilizing CiteSpace software, we analyzed publications, countries, institutions, authors, and keywords through a visual knowledge graph to assess research hotspots and trends.In total, 833 articles were identified, revealing a consistent increase in the number of annual publications in this field over the study period. The United States has emerged as the leading country in terms of publication volume, with Harvard University being the most prolific institution. Among the authors, Jan Potempa has the highest number of publications. Keyword analysis indicated that current research hotspots concerning the relationship between RA and the oral microbiome primarily focus on Porphyromonas gingivalis, periodontitis, inflammation, expression, and peptidylarginine deiminase. Investigating the mechanisms by which oral and intestinal microorganisms influence RA, as well as developing intervention strategies targeting these microbiotas, is anticipated to be a significant future research direction.This study characterized the trends in the literature regarding the relationship between RA and the oral microbiome, providing valuable insights for scholars pursuing further research.
Keywords: Bibliometrics, Rheumatoid arthritis, oral microbiome, Inflammation, Porphyromonas gingivalis
Received: 10 Mar 2025; Accepted: 27 Jun 2025.
Copyright: © 2025 Lin, Xu, Chen, Wang, Li, Ye and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chaoyan Hu, The Third Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China
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