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SYSTEMATIC REVIEW article

Front. Microbiol.

Sec. Systems Microbiology

Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1598443

Bibliometric analysis of sepsis and gut microbiota: From 2014 t o 2024

Provisionally accepted
Runze ZhangRunze Zhang1Chenxing HuoChenxing Huo2Chenming HeChenming He3Jielian LuoJielian Luo1Yunan ShanYunan Shan4Jiamin LuJiamin Lu2Ji Rong ZhangJi Rong Zhang2Wen ZhangWen Zhang2*Bangjiang FangBangjiang Fang2*
  • 1Emergency Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
  • 2Emergency Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
  • 3Emergency Department,, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
  • 4College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei Province, China

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Background: Sepsis is a life-threatening organ dysfunction caused by a dysreg ulated host response to infection, with pathological mechanisms closely linked t o intestinal flora imbalance. While gut microbiota influences sepsis progression through metabolic and immune regulation, systematic analyses of research tren ds remain limited. This bibliometric study comprehensively evaluates the sepsisgut microbiota field from 2014 to 2024. Methods: We analyzed 944 English articles from the Web of Science Core Co llection using CiteSpace and VOSviewer and other software. Bibliometric assess ments included publication trends, collaborative networks, geographic distributio ns, journal analyses, and keyword clustering. Results: The 944 publications involved 5,901 authors from 69 countries, publis hed in 405 journals, and cited 45,932 references. Research hotspots evolved fro m early focus on "necrotizing enterocolitis" and "premature infants" to recent e mphasis on "short-chain fatty acids" and "Candida albicans." Emerging topics i ncluded "sepsis-associated encephalopathy," with microbiology and critical care medicine emerging as interdisciplinary core fields. Conclusion: Gut microbiota's therapeutic potential in sepsis is increasingly reco gnized. Future research should prioritize microbial-targeted therapies, immune-ba rrier-metabolic network regulation, and integrated traditional Chinese-Western m edicine approaches.

Keywords: Bibliometric, Citespace, Gut Microbiota, Sepsis, VOSviewer

Received: 23 Mar 2025; Accepted: 28 May 2025.

Copyright: © 2025 Zhang, Huo, He, Luo, Shan, Lu, Zhang, Zhang and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Wen Zhang, Emergency Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Bangjiang Fang, Emergency Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material