ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1599107
This article is part of the Research TopicFecal Microbiota Transplants: challenges in translating microbiome research to clinical applicationsView all 25 articles
Therapeutic effect of fecal microbiota transplantation on hyperuricemia mice by improving gut microbiota
Provisionally accepted
Songjian Yuan1
Wenting Jia1Xiaomei Liu1
Ruzhen Liu2Man Cao2Yuting Wu2Yuantao Li2
Wei XU2
Chuanxing Xiao1,2*Zhenqiang Hong1*
Bangzhou Zhang1,2*- 1School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China, FUzhou, China
- 2Xiamen Treatgut Biotechnology Co., Xiamen, China
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The primary objective of this study was to assess the impact of fecal microbiota transplantation (FMT) on serum biochemical parameters, renal injury, and gut microbiota in hyperuricemia (HUA) mice. Methods: Six-week-old male C57BL/6J mice were given a high-purine diet and potassium oxonate injections to induce HUA, followed by a two-week FMT treatment. Regular body weight checks, serum biochemical analyses, and fecal sampling for 16S rRNA gene sequencing were conducted to evaluate the treatment's impact on gut microbiota. Results: The model group showed significant increases in uric acid (UA), creatinine (Cr), blood urea nitrogen (BUN) levels, and increased xanthine oxidase (XOD) activity compared to controls (P<0.05). FMT treatment effectively reduced these levels and XOD activity (P<0.05). At the genus level, specific taxa like Muribaculaceae and Prevotellaceae_UCG-001 were less abundant, while Blautia and Ruminiclostridium_9 were more abundant in the model group. Following FMT, gut microbiota composition returned to near-normal levels, with significant differences from the model group (P<0.05).This study demonstrates that FMT holds therapeutic potential for HUA mice by reducing UA levels, alleviating renal damage, and restoring gut microbiota balance.
Keywords: fecal microbiota transplantation, Hyperuricemia, microbiome, renal injury, Gut Microbiota
Received: 24 Mar 2025; Accepted: 18 Jul 2025.
Copyright: © 2025 Yuan, Jia, Liu, Liu, Cao, Wu, Li, XU, Xiao, Hong and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chuanxing Xiao, Xiamen Treatgut Biotechnology Co., Xiamen, China
Zhenqiang Hong, School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China, FUzhou, China
Bangzhou Zhang, Xiamen Treatgut Biotechnology Co., Xiamen, China
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