REVIEW article
Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1608137
The role of bacterial outer membrane vesicles in inflammatory response of acute-on-chronic liver failure
Provisionally accepted
- 1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital. Taiyuan, 030032, China., Taiyuan, China
- 2Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital. Taiyuan, 030032, China, Taiyuan, China
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Acute-on-chronic liver failure (ACLF) is a clinical syndrome that manifests as acute deterioration of liver function due to a series of etiologies and triggers in patients with pre-existing chronic liver diseases. Systemic inflammatory response is the major feature of ACLF. Gut microbiota dysbiosis impairs the intestinal barrier, facilitating the translocation of microorganisms and their metabolites into the liver and thereby exacerbating liver inflammation and disease progression. Recent studies have revealed that bacterial outer membrane vesicles (OMVs) derived from gut microbiota act as key mediators in microbiota-host cell communication. This article elucidates the possible roles of OMVs in ACLF inflammation and their underlying mechanisms.
Keywords: Acute-on-chronic liver failure, Bacteria, outer membrane vesicles, Inflammation, cirrhosis, Gut-liver axis
Received: 08 Apr 2025; Accepted: 20 Jun 2025.
Copyright: © 2025 Qin, Wang, Yan, Zhao and Yao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jia Yao, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital. Taiyuan, 030032, China, Taiyuan, China
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