ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1609148
This article is part of the Research TopicPathogenic microorganisms and biosafetyView all 4 articles
Risk Factors of Carbapenem-resistant Acinetobacter baumannii Contamination on Hospital Surface Environments: A Multi-year Environmental Monitoring Study in Shanghai, China
Provisionally accepted
- Shanghai Municipal Center for Disease Control and Prevention (SCDC), Shanghai, China
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Background Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a significant threat to human health in hospital settings. The environment could serve as a reservoir for CRAB, since Acinetobacter baumannii (AB) exhibits strong survival capabilities in the environment. Therefore, it is necessary to investigate the distribution of CRAB in the environment and explore the risk factors associated with its positive detection rate.Methods From 2018 to 2023, a long-term environmental monitoring of the surfaces of objects around CRAB patients was conducted in 16 hospitals in Shanghai.During each quarter, both 48 environmental samples and information about the samples were collected. Bacterial isolates were collected, and antimicrobial susceptibility testing (AST) was performed in accordance with the Clinical and Laboratory Standards Institute (CLSI) guidelines (2019-2021 edition). The CRAB detection rate in environmental samples was compared across different variables. For nominal categorical variables, intergroup differences were analyzed using the Pearson χ² test.Additionally, logistic regression analysis was employed to identify risk factors associated with CRAB-positive environmental samples.Result A total of 10,268 samples were included in this study, among which 391 tested positive for CRAB. The overall CRAB positivity rate on environmental surfaces was 3.81%. Significant differences in positivity rates were observed across hospital levels, departments, sampling locations, and exposure frequencies (P < 0.05).Compared to Class B secondary hospitals, the following hospital classes showed significantly higher risks of CRAB detection: Class A secondary hospitals (OR=13.34,
Keywords: Carbapenem-resistant Acinetobacter baumannii, environment, risk factor, Hospital, Infection
Received: 10 Apr 2025; Accepted: 20 May 2025.
Copyright: © 2025 Zhang, Tian, Wu, Chen, Shi, Ge, Zhu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Renyi Zhu, Shanghai Municipal Center for Disease Control and Prevention (SCDC), Shanghai, China
Jian Chen, Shanghai Municipal Center for Disease Control and Prevention (SCDC), Shanghai, China
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