Gut Microbiome and Metabolome Interactions in Crohn's Disease: Mechanistic Insights into Exclusive Enteral Nutrition-Induced Remission

Weiwei Zheng^1,2,3,4Quan Zhou⁵Mengli Xue^1,2,3,4Xing Yu^1,2,3,4Xue'E Chen^1,2,3,4Jintong Chen^1,2,3,4Chengdang Wang^1,2,3,4*

• ¹Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China
• ²Department of Gastroenterology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China
• ³Fujian Clinical Research Center for Liver and Intestinal Diseases, Fuzhou, China
• ⁴The First Clinical Medical College of Fujian Medical University, Fuzhou, China
• ⁵Department of Public Health, Fuzhou Center for Disease Control and Prevention, Fuzhou, China

contributed equally as co-first authors to the writing of the manuscript and performed the project, including conceptualization, data processing, data analysis, and software. Mengli Xue provided valuable suggestions on data analysis and assisted in revising the manuscript. Xing Yu contributed to data analysis and discussion of the results. Xue'e Chen and Jintong Chen provided technical support and assisted in data organization and statistical analysis. Chengdang Wang supervised the project, managed project administration, acquired funding, and contributed to writing and editing the manuscript. All authors have read and agreed to the published version of the manuscript.