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ORIGINAL RESEARCH article

Front. Microbiol.

Sec. Microorganisms in Vertebrate Digestive Systems

Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1616222

The protective effect of Blautia coccoides in secondary injury of intracerebral hemorrhage

Provisionally accepted
Xian ShaoXian Shao1Matao ZhengMatao Zheng2Chenglong YeChenglong Ye3Jiafeng LuJiafeng Lu1Mengyun LiMengyun Li1Kuiwei SuKuiwei Su4Hui LinHui Lin1Lingyan HeLingyan He5Xuchen QiXuchen Qi6*Jianli WangJianli Wang3
  • 1Department of Medical Research Center, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China
  • 2Second Clinical Medical School, Zhejiang Chinese Medical University, Hangzhou, Jiangsu Province, China
  • 3Department of Neurosurgery, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China, Shaoxing, China
  • 4Department of Stomatology, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China, Shaoxing, China
  • 5Department of Traditional Chinese Medicine, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China, Shaoxing, China
  • 6Department of Neurosurgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

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Intracerebral hemorrhage (ICH) is a severe stroke with high rates of disability and mortality.Emerging evidence suggests a link between neurological disorders and gut microbiota dysbiosis, though the underlying mechanisms remain unclear. To investigate the role of gut microbiota in ICH, we conducted metagenomic analysis of fecal samples from 35 healthy individuals and 36 patients with ICH, including 29 survivors and seven deceased patients.Blautia genus identified as potential biomarkers. We also established an ICH mouse model via stereotactic autologous blood injection to assess the therapeutic potential of Blautia genus.Blautia coccoides (BC), a representative strain, improved neurofunctional outcomes in ICH mice, reduced tissue damage and neuronal apoptosis, and decreased glial cell activation markers (GFAP and Iba1). BC treatment also lowered the serum levels of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and partially restored gut microbial homeostasis. These findings suggest that BC plays a crucial role in ICH progression and may serve as a potential therapeutic agent by modulating gut microbiota. Further research and clinical trials are necessary to validate its efficacy and safety in humans.

Keywords: intracerebral hemorrhage, Gut Microbiota, Blautia coccoides, Neuroprotection, Neuroinflammation

Received: 09 May 2025; Accepted: 12 Aug 2025.

Copyright: © 2025 Shao, Zheng, Ye, Lu, Li, Su, Lin, He, Qi and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Xuchen Qi, Department of Neurosurgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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