ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1617522
A Decade of Antimicrobial Resistance Trends in Pseudomonas aeruginosa: Insights from a Tertiary Care Hospital in Saudi Arabia (2013-2022) Type of article: Original article
Provisionally accepted
Yahya Shabi1,2*
Abdullah Alqarni3Ali Albashabshi4Tarik Alazraqi5
Glenn Patriquin6Abdulah OS Bawazeer7Safia Abdullah5Sara Habbash5Ali Somily8Saeed MS Alhamhhum7
Abdulah J Alqahtani9- 1King Khalid University, Abha, Saudi Arabia
- 2Department of Microbiology and Clinical Parasitology, College of Medicine, Abha, Saudi Arabia
- 3Department of Family Medicine, Aseer Central Hospital, Abha 62523, Saudi Arabia, Abha, Saudi Arabia
- 4Department of Medicine, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia, Abha, Saudi Arabia
- 5Department of Internal Medicine, Aseer Central Hospital, Abha 62523, Saudi Arabia, Abha, Saudi Arabia
- 6Division of Microbiology, Department of Pathology and Laboratory Medicine, Nova Scotia Health, Halifax, Nova Scotia, Canada, Halifax, Canada
- 7Department of Microbiology, Aseer Central Hospital, Abha 62523, Saudi Arabia, Abha, Saudi Arabia
- 8Department of Pathology / Microbiology unit, King Khalid University Hospital, Riyadh, Saudi Arabia, Riyadh, Saudi Arabia
- 9Department of Microbiology and Clinical Parasitology, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia, Abha, Saudi Arabia
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Background: Pseudomonas aeruginosa (PA) is a significant cause of nosocomial infections, and increasing antimicrobial resistance complicates management.Objectives: To characterize antimicrobial susceptibility trends, we conducted a retrospective study of PA clinical isolates over 10 years (2013-2022) at a tertiary care hospital in Saudi Arabia.Results: A total of 2,490 PA isolates were analyzed (1,452 from general wards and 1,038 from ICUs). Carbapenem resistance was observed in 40% of isolates; 37.5% were multidrug-resistant (MDR), 5.3% were extensively drug-resistant (XDR), and 3.5% met the criteria for difficult-to-treat resistance (DTR). This study provides an overview of PA resistance pattern trends in Saudi Arabia and emphasizes the importance of establishing an antimicrobial stewardship program.
Keywords: Pseudomonas aeruginosa, nosocomial infections, Multidrug-resistant (MDR), extensively drug-resistant (XDR), difficult-to-treat resistance (DTR), Saudi Arabia
Received: 25 Apr 2025; Accepted: 28 May 2025.
Copyright: © 2025 Shabi, Alqarni, Albashabshi, Alazraqi, Patriquin, Bawazeer, Abdullah, Habbash, Somily, Alhamhhum and Alqahtani. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yahya Shabi, King Khalid University, Abha, Saudi Arabia
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