REVIEW article
Front. Microbiol.
Sec. Virology
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1617998
This article is part of the Research TopicEffective Therapeutic Strategies, Including Treatments, Vaccines, and Immunotherapies, for Combating Zoonotic Viruses and Improving Global Health OutcomesView all articles
Molecular Epidemiology and Immunopathogenesis of Bovine Viral Diarrhea Virus: A Growing Threat to Regional Cattle Industry of Xinjiang, China
Provisionally accepted
- 1Tarim University, Aral, Xinjiang Uyghur Region, China
- 2Huazhong Agricultural University, Wuhan, Hubei Province, China
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Bovine viral diarrheal virus (BVDV), identified as a serious global pathogen, presents a significant and formidable challenge for the global cattle sector. This presents not only serious economic consequences but also serious immunopathological consequences causing lasting impacts. In the Chinese province of Xinjiang, where the ruminants are high and the topographical features unique and contribute towards complex epidemiology, multiple genotypes of the BVDV are continuously interacting and adapting. This includes the persistent presence of the earlier predominant BVDV1, the rising trend towards the antigenically complex BVDV2, and the recent presence of the HoBilike (BVDV3) strain, contributing toward complexity. The purpose of this review is to present a detailed analysis relative to the molecular epidemiology, genomic diversity levels, and complex pathology associated with the persistence and spreading of the infection by the BVDV. In light of the country's inability to execute the efficacious eradication of the infection, stringent biosafety measures need to be adopted, the genomic investigation has to be increased, and the establishment of the multi-valent vaccine for the induction of the local strain of the infection should be encouraged. These steps need to be taken towards the rising danger of the presence of the BVDV, not only towards the province but also towards the larger territories beyond.
Keywords: bovine viral diarrhea, bovine viral diarrhea virus, Prevalence, Epidemiology, Pathogenesis, Xinjiang
Received: 25 Apr 2025; Accepted: 26 Jun 2025.
Copyright: © 2025 Gao, Kuang, Yin, Zhang, Kulyar and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jindong Gao, Tarim University, Aral, 843300, Xinjiang Uyghur Region, China
Changmin Hu, Huazhong Agricultural University, Wuhan, 430070, Hubei Province, China
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