REVIEW article
Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1618046
Nanomedicine in Fungal Keratitis: Current Applications and Future Prospects
Provisionally accepted
Yuyang Xiao
Yifei Yang
Binyu Sun
Meng YangJiamiao LangMintao DongZengsihan ChenShanshan Chen*
Shengfeng Wang*- Central South University, Changsha, China
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Fungal keratitis (FK) poses a significant public health challenge, causing substantial harm to human health and the socio-economic landscape. However, due to the special anatomical and physiological characteristics of the eye, the current therapeutic drugs for FK are not effective, which brings obstacles to the clinical treatment of FK. Nanomedicine is a new therapeutic method that has emerged in the field of FK therapy in recent years. On the one hand, nanomaterials can directly kill fungi by separating ions, and on the other hand, the drug delivery system (DDS) composed of nanomaterials can target and deliver traditional drugs to the affected area and play a bactericidal role, with a significantly higher effect than traditional therapy. This review begins with a bibliometric analysis of research progress in FK nanomedicine. Then we describe the mechanism and effect of various nanomedicine in the treatment of FK from the perspective of direct and indirect treatment, focusing on the attack of nanomedicine on biofilm and DDS composed of nanomaterials. Finally, this field is prospected in order to provide new insights and ideas for the development of FK nanomedicine.
Keywords: Fungal keratitis, Nanomedicine, drug delivery system, Treatment, bibliometric analysis
Received: 25 Apr 2025; Accepted: 26 Jun 2025.
Copyright: © 2025 Xiao, Yang, Sun, Yang, Lang, Dong, Chen, Chen and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shanshan Chen, Central South University, Changsha, China
Shengfeng Wang, Central South University, Changsha, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.