REVIEW article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1619323
Changes in Intestinal Microbiota in Patients with Pancreatic Cancer: A Systematic Review and Meta-Analysis
Provisionally accepted
- Affiliated Hospital of Hebei University, Baoding, Hebei Province, China
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Background: Pancreatic cancer (PC) is a highly aggressive malignancy with an asymptomatic early stage, often resulting in rapid invasion of adjacent tissues and organs and a high mortality rate. Recent research has increasingly examined the gut microbiome as a potential factor in PC pathogenesis. Although changes in gut microbiota composition have been reported in patients with PC, a comprehensive evaluation of the relationship between gut microbiota and PC has not been systematically conducted.Methods: A systematic search of PubMed, Web of Science, Embase, and Cochrane databases was conducted, and a meta-analysis was performed on ten studies including a total of 324 patients with PC.The meta-analysis did not identify a statistically significant difference in α-diversity and microbial richness between patients with PC and those in the control group. However, a decrease in Bacteroides, Neisseria, Porphyromonas, Prevotella, and Actinomyces was observed in patients with PC, while Fusobacterium, Rothia, Streptococcus, Veillonella, and Escherichia-Shigella levels were increased.Conclusions: This meta-analysis demonstrates an association between PC and changes in gut microbiota composition at both the species and genus levels.
Keywords: Gut microbes, intestinal microbiota, Meta-analysis, Pancreatic Cancer, Systematic review
Received: 28 Apr 2025; Accepted: 15 Jul 2025.
Copyright: © 2025 Liang, Liu, Zhang, Yang, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiao-Wei Wang, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China
Nan Zhang, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China
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