REVIEW article
Front. Microbiol.
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1619626
This article is part of the Research TopicBreaking the Biofilm Barrier: Analysis of Molecular Mechanisms Underlying Biofilm Formation and Identification of Novel Antimicrobial ApproachesView all 9 articles
A Comprehensive Review of the Pathogenic Mechanisms of Pseudomonas aeruginosa: Synergistic Effects of Virulence Factors, Quorum Sensing, and Biofilm Formation
Provisionally accepted
- 1School of Basic Medical Sciences, Beihua University, Jilin, China
- 2Beihua University, The Center for Infection and Immunity, Jilin, China
- 3Affiliated Hospital of Beihua University, Department of Science and Education, Jilin, China
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interactions in vivo. Notably, targeting QS with small-molecule inhibitors has shown promise in attenuating pathogenicity, yet translating these findings into clinical therapies requires more nuanced understanding of resistance emergence and host microbiome effects.We propose that future investigations prioritise (1) the structural biology of QS receptors to guide rational inhibitor design; (2) single-cell and organ-on-a-chip models to dissect biofilm heterogeneity; (3) dual-omics approaches to map host-pathogen signaling crosstalk; and (4) environmental modulators-such as iron availability and shear stress-that fine-tune virulence expression. Such multidisciplinary efforts will underpin the development of next-generation anti-virulence therapies, ultimately improving prevention and treatment of P. aeruginosa infections and safeguarding public health.
Keywords: Pseudomonas aeruginosa, Virulence Factors, Quorum Sensing, Biofilm, Immune Evasion
Received: 29 Apr 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Zhang, Li, Zhang, Zheng, Zhou, Hou, Li and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huiming Han, School of Basic Medical Sciences, Beihua University, Jilin, China
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