REVIEW article
Front. Microbiol.
Sec. Virology
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1620775
Inositol metabolism as a broad-spectrum antiviral target
Provisionally accepted
Kunlakanya Jitobaom
Prasert Auewarakul*- Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
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Inositol plays many important roles in cellular processes through its various derivatives including phosphatidylinositol phosphates. Viruses use phosphatidylinositol phosphates for their replication in multiple processes including entry, formation of replication organelles, assembly and release. For these processes, viruses recruit phosphatidylinositol kinases to meet their demand of phosphatidylinositol phosphates. Inhibitors of phosphatidylinositol kinases have been shown to inhibit various viruses. The complexity of various types and isoforms of phosphatidylinositol kinases can be a problem in developing a broad-spectrum antiviral as different viruses use various types and isoforms of the enzyme. Inositol monophosphatase is an enzyme required for both de novo biosynthesis and intracellular recycling of inositol. It can provide a chokepoint to limit the availability of cellular inositol, phosphatidylinositol, and phosphatidylinositol phosphates. It can be a promising target for broad-spectrum antiviral development.
Keywords: phosphatidylinositol, inositol monophosphatase, phosphatidylinositol kinase, myo-inositol metabolism, Broad-spectrum antiviral, host-virus interaction
Received: 30 Apr 2025; Accepted: 12 Aug 2025.
Copyright: © 2025 Jitobaom and Auewarakul. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prasert Auewarakul, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
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