Host SUMOylation in Bacterial Infections and Immune Defense Mechanisms

Yuhua Xu¹Xi Ma¹Zhifeng Wu¹Ruitong Huang¹Chenhua Liao¹Di Huang¹Yujun Tang¹Chengbin Zhu¹Yaqi Wang¹Siyuan Zhang¹Peng Liu¹Jiaofeng Peng^2*

• ¹University of South China, Hengyang, China
• ²Hengyang Central Hospital, Hengyang, China

SUMOylation, the covalent attachment of small ubiquitin-like modifier proteins (SUMO) to lysine residues of target substrates, has emerged as a crucial posttranslational modification regulating various cellular processes. Recent studies have revealed that SUMOylation also plays significant roles in host-pathogen interactions during bacterial infections. On the one hand, SUMOylation can modulate host innate immune responses, such as inflammatory signaling and autophagy, to defend against invading bacteria. On the other hand, certain bacterial pathogens have evolved strategies to exploit or manipulate the host SUMOylation machinery to promote their survival and replication. Some bacterial effector proteins directly target host SUMO enzymes or SUMO-conjugated substrates to disrupt host defense mechanisms.Interestingly, a few bacteria have been found to possess their own SUMOylation systems that may contribute to bacterial virulence and stress adaptation. This review summarizes the current understanding of the complex interplay between SUMOylation and bacterial infection, highlighting the dual roles of SUMOylation in host defense and bacterial pathogenesis. We discuss the mechanisms by which SUMOylation regulates host immune responses against bacterial infection and how bacterial pathogens hijack host SUMOylation for their own benefit. Moreover, we explore the potential of targeting SUMOylation as a novel therapeutic strategy for combating bacterial infections. Further research into the intricate relationship between SUMOylation and bacterial infection may provide valuable insights for developing innovative antiinfective therapies.