SYSTEMATIC REVIEW article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1623875
Global research trends in gut microbiota and cellular senescence: a bibliometric and visual analysis from 2015 to 2025
Provisionally accepted
- 1College of Life Sciences, Shaanxi Normal University, Xi'an, China 710119, Xi'an, China
- 2College of Basic Medical Sciences, Dali University, dali, China
- 3College of Clinical Medicine, Dali University, dali, China
- 4Department of Gastroenterology, Northeast Yunnan Regional Central Hospital, Zhaotong, China
- 5College of Public Health, Dali University, dali, China
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The human body's intestinal microbiota is a vital "organ" that coexists with it and is intimately linked to both human health and illness. Human intestinal microbiota and its metabolites are a crucial component in the development of several diseases, according to an increasing number of studies that have started to examine the function of intestinal microbiota in various illnesses. Numerous recent studies have also shown a direct relationship between cellular senescence and the gut flora. The purpose of this study was to use bibliometric techniques to examine the themes and subjects of scholarly publications in this discipline during the past ten or so years. Method: The Web of Science Core Collection (WOSCC) database was searched for material published between 2015 and 2025. The study used VOSviewer and Citespace to explore the characteristics of this literature. Specific analyses covered the number of publications, countries/regions studied, research institutions, authors, journals, citations, and keyword hotspots.Results: This study analyzed 2,911 publications on research related to gut microbiota and cellular senescence between 2015 and 2025, with a rapid increase in annual publications from 2020 onwards, peaking in 2024 (492 publications), with the United States and China dominating in terms of publications, and the University of Groningen demonstrating excellent academic influence in this field, with Chen, Wei, De Vos, Paul and Zhang, Hao being the three most influential authors in this field, Nature is the most influential journal in its field with 5,857 total citations, "Oxidative stress", "Alzheimer's disease" and "immunotherapy" are current hot topics of research.Research in the field of gut microbiota and cellular aging is growing rapidly. Current research focuses on gut microbiota and disease mechanisms (e.g., Alzheimer's disease, immunotherapy, oxidative stress) and clinical translation, and interdisciplinary collaborations and technological innovations are expected to drive further development in this field. This bibliometric study provides a comprehensive analysis of the field and offers new ideas for future research.
Keywords: Gut Microbiota, cellular senescence, Disease, Citespace, VOSviewer, bibliometric analysis
Received: 06 May 2025; Accepted: 24 Jul 2025.
Copyright: © 2025 Huang, Li, Gu, Li, Chen and Xiong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hongyun Chen, College of Public Health, Dali University, dali, China
Wei Xiong, College of Basic Medical Sciences, Dali University, dali, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.