REVIEW article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1625098
Role of Curcumin in Altering Gut Microbiota for Anti -Obesity and Anti -Hyperlipidemic Effects
Provisionally accepted
- Hunan Agricultural University, Changsha, China
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Obesity significantly impacts that influence the health and economy of modern society, and the prevention and treatment of obesity a key focus of social research. The main reason for obesity is that the excessive accumulation of body fat due to metabolic dysfunction, which may result in atherosclerosis, insulin resistance and abnormal lipid metabolism. So far, a number of mechanisms of intestinal flora and plant extracts have been found and applied to the treatment of obesity. However, because of the complexity of gut microbiome composition, it is still not clear which microbiome has a direct relationship with obesity. Curcumin (CUR) has a longstanding and important position in Traditional Chinese Medicine (TCM). It is a polyphenolic compound derived from the rhizome of Curcuma longa. CUR has been widely studied in recent years for its multiple biological activities. In addition to its anti -inflammatory and antioxidant properties, CUR also shows potential in anticancer, anti -microbial, and neuroprotective effects. This review aims to systematically synthesize the current evidence on the effects and mechanisms of CUR targeting gut microbiota in obesity treatment, analyze the progress of CUR research in fat reduction and weight loss, and specifically clarify its role in modulating gut microbiota to exert both anti-obesity and anti-hyperlipidemic effects. By doing so, we seek to illuminate the intricate relationship between CUR, gut microbiota, and obesity with associated hyperlipidemia.
Keywords: Curcumin, Gut microbiome (GM), Weight Loss, Lipid-lowering, Obesity
Received: 09 May 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 FENG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: JINGXI FENG, Hunan Agricultural University, Changsha, China
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