REVIEW article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1633029
The Role of Gut Microbiota in Insulin Resistance: Recent Progress
Provisionally accepted
- 1Third Hospital of Shanxi Medical College, Taiyuan, China
- 2Shanxi Bethune Hospital, Taiyuan, China
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Insulin resistance (IR) is the most critical pathophysiological basis of type 2 diabetes mellitus(T2DM). The mechanisms underlying IR are extremely complex, with variations observed among different patients and different tissues. Current research has gradually revealed characteristics of the gut microbiota and its role in metabolizing major nutrients during IR. The interaction between microbial communities and host metabolism has become a hotspot in modern medical research. This review aims to provide a comprehensive understanding of microbial metabolism related to IR by elucidating the effects of microbiota-carbohydrate metabolism and microbiota-host interactions on IR.Such insights may contribute to improving IR and offer novel perspectives for its treatment.
Keywords: Insulin Resistance, gut microbiota metabolism, Carbohydrate fermentation, host-microbiota crosstalk, short-chain fatty acids
Received: 22 May 2025; Accepted: 08 Jul 2025.
Copyright: © 2025 Ji, Chen, Liu, Liu and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jian jin Guo, Third Hospital of Shanxi Medical College, Taiyuan, China
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