PERSPECTIVE article
Front. Microbiol.
Sec. Virology
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1642090
The role of HIV-1 Gag and genomic RNA interactions in virion assembly
Provisionally accepted
Takaaki Koma1
Bao Quoc Le1
Khanh Quoc Tran1
Naoya Doi1
Tomoyuki Kondo1
Kei Miyakawa2
Akio Adachi1*
Masako Nomaguchi1*- 1Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan
- 2AIDS Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku-ku, Japan
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The virion assembly represents a critical aspect of producing infectious progenies required for HIV-1 replication. Each step in that process, such as Gag-membrane binding, Gag-genomic RNA binding/packaging, Gag multimerization, and viral particle budding, has been extensively analyzed in a stepwise and specific manner. While Gag proteins are the primary drivers of HIV-1 virion assembly, the interactions between Gag and RNA play a significant role in regulating the process. This article provides an updated overview and perspective on HIV-1 virion assembly, with a particular focus on the role of Gag-RNA interactions.
Keywords: HIV-1, virion assembly, Gag, RNA, membrane, Gag oligomerization, Gag multimerization
Received: 06 Jun 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Koma, Le, Tran, Doi, Kondo, Miyakawa, Adachi and Nomaguchi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Akio Adachi, Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan
Masako Nomaguchi, Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan
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