REVIEW article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1663138
This article is part of the Research TopicThe Role of Gut Microbes and Their Metabolites in Metabolic Diseases: Mechanisms and Therapeutic TargetsView all 18 articles
Probiotics in the Prevention and Treatment of Calcium Oxalate Kidney Stones: Mechanisms and Therapeutic Potential
Provisionally accepted
- 1Guizhou Medical University, Guiyang, China
- 2The Affiliated Hospital of Guizhou Medical University, Guiyang, China
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Background: Kidney stones, particularly calcium oxalate stones, remain a significant health issue despite advances in treatment techniques. Residual stones that persist after treatment can lead to recurrent stone formation and further complications. The role of gut microbiota, specifically probiotics, in modulating oxalate metabolism has gained increasing attention as a potential therapeutic strategy to reduce residual stones and prevent recurrence. Summary: This paper reviews the potential of probiotics, including recombinant strains, in the treatment of calcium oxalate kidney stones. Probiotics are thought to promote the degradation of oxalate in the gut, thereby reducing its absorption and preventing stone formation. Recent studies have highlighted the beneficial effects of probiotic interventions on gut microbiota composition, oxalate degradation pathways, and calcium oxalate stone formation. Moreover, recombinant probiotics, engineered to enhance oxalate-degrading capabilities, hold promise for improving treatment outcomes. Key messages: This review summarizes recent advancements in the use of probiotics for the prevention and treatment of calcium oxalate kidney stones, with a focus on their role in oxalate degradation and the potential of recombinant probiotics to improve treatment outcomes.
Keywords: Probiotics, Kidney Stones, Calcium oxalate stones, Gut Microbiota, Oxalatedegradation, Recombinant probiotics
Received: 22 Jul 2025; Accepted: 15 Sep 2025.
Copyright: © 2025 Yang, Li, Li and Jia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Benzhong Jia, jiabz123@163.com
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