ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Microbiotechnology
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1667928
Biosynthesis, Optimization, and Multifunctional Biomedical Applications of Gold Nanoparticles Mediated by Streptomyces sp. YJD18
Provisionally accepted
- 1Zhuhai College of Science and Technology, Zhuhai, China
- 2Xinjiang University College of Life Science and Technology, Urumqi, China
- 3Shihezi University College of Life Science, Shihezi, China
- 4Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital Baoshan Branch, Shanghai, China
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This study employed extracellular secretions from Streptomyces sp. YJD18, isolated from saline-alkali soil, to synthesize gold nanoparticles (AuNPs) using optimized conditions: 60 min boiling, 48 h mycelial suspension, pH 6.25, 1.0 mM chloroauric acid, 1:1 supernatant-to-water ratio, and 9.0 g mycelial wet weight. AuNP formation was confirmed by a yellow-to-ruby red color shift and a 525 nm UV-Vis absorption peak. TEM and SAED revealed irregular, polycrystalline spheres with good dispersity. Zeta potential (-11.6 mV) and DLS (20-30 nm) confirmed uniform surface properties and narrow size distribution. FTIR showed C-H and amide groups did not contribute to AuNP synthesis. The AuNPs exhibited dose-dependent cytotoxicity against cancer (cervical, lung, liver, breast) and normal (kidney, liver) cells, optimal wound healing at 30 µg/mL (58.07% at 48 h), and concentration-dependent DPPH scavenging (IC50: 12,419.00 µg/mL), suggesting biomedical potential.
Keywords: gold nanoparticles, Streptomyces sp. YJD18, Cytotoxicity, Wound Healing, antioxidant activity, Microbial synthesis
Received: 18 Jul 2025; Accepted: 01 Aug 2025.
Copyright: © 2025 Lin, Niu, Zhang, Shen, Hu, yin and GUO. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
wenyuan yin, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital Baoshan Branch, Shanghai, China
FEI GUO, Zhuhai College of Science and Technology, Zhuhai, China
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