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ORIGINAL RESEARCH article

Front. Microbiol.

Sec. Microorganisms in Vertebrate Digestive Systems

Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1671409

This article is part of the Research TopicRodent Model Organisms: Therapeutic Treatments and Drugs Interaction with the Gut Microbiome, Volume IIView all 7 articles

Sustained Hyperuricemia Induces the Disturbance of Enterohepatic Circulation via 12α-Hydroxy BA and Gut Microbiota

Provisionally accepted
Tong ZouTong Zou1Ruixiao ZhangRuixiao Zhang2Zeqing ChenZeqing Chen3Haiping DuanHaiping Duan3Wang ZhaoguoWang Zhaoguo3Ruipeng GaoRuipeng Gao1Xin ChenXin Chen3Hongqiang WangHongqiang Wang1Yue ZhaoYue Zhao4Xiaofeng WangXiaofeng Wang1*Shichao XingShichao Xing1*
  • 1Qingdao University, Qingdao, China
  • 2Qingdao Municipal Hospital Group, Qingdao, China
  • 3Qingdao Municipal Center for Disease Control and Prevention, and Qingdao Institute of Preventive Medicine, Qingdao, China
  • 4King's College London, London, United Kingdom

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Hyperuricemia (HUA) has become a worldwide health issue and has attracted much public attention. This study was carried out to elucidate the roles of bile acids (BAs) and their associations with gut microbiota in HUA rat model. In the process, we generated normal control(N) and HUA rat models, and determined liver, serum and ileum content bile acid (BA) profiles of HUA and N rats with a targeted metabolic approach and analyzed gut microbiota by 16S rDNA gene sequencing. The results were that hyperuricemia induced elevated levels of cholic acid (CA) in liver,and elevated levels of Taurocholic acid (TCA), Glycocholic acid (GCA) and Taurodeoxycholic acid (TDCA) in the ileum content and particularly the increases in the levels of total 12α-hydroxy bile acid in ileum content, which were consistent with the increased levels of CA in liver. These changes are correlated to an increase in abundance of genera Allobaculum and Bifidobacterium. Our investigation revealed the fluxes of bile acids and their association with gut microbiota in HUA and provides new ideas for the study of metabolic diseases in hyperuricemia.

Keywords: Hyperuricemia, Gut Microbiota, Bile acid, 12α-hydroxy, Uric Acid

Received: 24 Jul 2025; Accepted: 10 Oct 2025.

Copyright: © 2025 Zou, Zhang, Chen, Duan, Zhaoguo, Gao, Chen, Wang, Zhao, Wang and Xing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Xiaofeng Wang, wangxf212@163.com
Shichao Xing, xingshichao@qdu.edu.cn

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