MINI REVIEW article
Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1674456
Mesenchymal Stromal Cells for Pseudomonas aeruginosa Pneumonia: Mechanisms, Preclinical Evidence, and Translational Barriers
Provisionally accepted
- Wenzhou Medical University, Wenzhou, China
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Pseudomonas aeruginosa, as an important pathogenic bacterium in nature, is particularly prone to cause severe pulmonary infections in patients with weakened immune function, which poses a significant threat to the survival and quality of life of patients. In recent years, Mesenchymal stromal Cells (MSCs) have become a hot topic in the antibacterial research due to their superior immunomodulatory ability and tissue repair characteristics. Existing studies have shown that MSCs have significant potential in improving the immune response to pulmonary infections and promoting tissue repair and regeneration. However, although multiple studies have explored the application of MSCs in pulmonary infections, there are still problems such as unclear mechanisms and high difficulty in clinical translation. This article aims to summarize the latest research progress of MSCs in the treatment of Pseudomonas aeruginosa pulmonary infections, analyze their potential mechanisms of action, clinical application situations, and future research directions, and provide references for in-depth clinical and basic research in this field.
Keywords: Mesenchymal Stromal Cells, Pseudomonas aeruginosa, pulmonary infection, immuneregulation, Therapeutic progress
Received: 28 Jul 2025; Accepted: 06 Oct 2025.
Copyright: © 2025 Zhang, Yu and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ze Yu, zeyunfu@163.com
Yue-Chuan Shen, 13758031525@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.