REVIEW article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
This article is part of the Research TopicThe Role of Gut Microbes and Their Metabolites in Metabolic Diseases: Mechanisms and Therapeutic TargetsView all 27 articles
Bile acid signaling mediates gut microbiota regulation of host lipid metabolism
Provisionally accepted
- 1Guangxi University, Nanning, China
- 2Hunan Agricultural University, Changsha, China
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Although advancements in the study of gut microbiota have clarified the close association between gut microbiota and the host's metabolism, the underlying mechanism remains unclear. Bile acids are important components of the host's metabolism and are deeply influenced by gut microbiota. In recent years, significant progress has been made in the study of how gut microbiota regulate their host's lipid metabolism through bile acids. This review summarizes the enterohepatic circulation of bile acids, the interaction between gut microbiota and bile acids, and the role of gut microbiota-bile acid signaling in the regulation of lipid metabolism. Finally, this review examines the effects of bile acid metabolism disorders on obesity. This review aims to provide a novel perspective for understanding the relationship between gut microbiota and the host's lipid metabolism.
Keywords: Gut Microbiota, Bile acids, Lipid Metabolism, Signal pathway, Enterohepatic Circulation
Received: 01 Sep 2025; Accepted: 31 Oct 2025.
Copyright: © 2025 刘, 郑, He, Li, Yin, Ma and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jie Ma, liu03094919@163.com
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