REVIEW article
Front. Microbiol.
Sec. Microbial Symbioses
Microbiome-Immune Crosstalk in Allergic Rhinitis: Lung and Intestinal Microbiota Mechanisms
Provisionally accepted
- 1山西中医药大学第二临床学院, 山西省太原市晋中市, China
- 2山西省针灸医院, 山西省太原市, China
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Allergic rhinitis (AR) is a prevalent immune-mediated upper respiratory disorder that manifests as an itchy nose, nasal congestion, a runny nose, and other symptoms. Emerging research suggests that AR, beyond its IgE-mediated hypersensitivity, indirectly influences the immune system by altering the equilibrium of the lung and intestinal microbiota. Therefore, future research should systematically characterize the mechanistic involvement of the respiratory and intestinal microbiomes in AR development, which may reveal innovative therapeutic targets. This review highlights the mechanisms by which the lung and intestinal microbiota contribute to the pathogenesis of AR and discusses potential therapeutic strategies.
Keywords: allergic rhinitis (AR), Lung microbiota, intestinal microbiota, immune response, microbiome-immune crosstalk
Received: 02 Sep 2025; Accepted: 18 Nov 2025.
Copyright: © 2025 Wang, Zhai, Hu and Lv. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yu‘e Lv, shanxitengtong1@126.com
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