REVIEW article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
This article is part of the Research TopicNew Horizons in Gut Microbiome Research for Enhancing Livestock ProductivityView all 25 articles
Winning the battle of intestinal peace with Bacillus - A multifaceted approach to animal health, immunity, and future applications in monogastric livestock production
Provisionally accepted
Nuria Vieco-Saiz1
Olga Lemâle2Nicholas Evans3Wanderley M. Quinteiro-Filho4Amine Mellouk1Jessika Consuegra1Haitham Yakout3
Tim Goossens5*- 1Adisseo France S.A.S, European Laboratory of Innovation, Science and Expertise, Saint Fons, France
- 2Adisseo NL B.V., Raamsdonksveer, Netherlands
- 3Adisseo USA Inc, Alpharetta, United States
- 4Adisseo Brasil Nutriçao Animal Ltda, São Paulo, Brazil
- 5adisseo, Sint-Niklaas, Belgium
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This review focuses on the application of Bacillus-based probiotics in livestock production, emphasizing their potential to enhance animal health, growth performance, and welfare through modulation of the gut microbiota, immune function, and nutrient absorption. Bacillus probiotics, particularly spore-forming strains, offer advantages such as stability during feed processing or the ability to survive gastrointestinal conditions, germinate and produce beneficial metabolites in the intestine. The mechanisms by which Bacillus probiotics exert their effects include influencing microbial communities, producing bioactive compounds, and strengthening gut barrier integrity, which together lead to improved digestive health and resistance to pathogens. Additionally, the challenges in standardizing their effects and identifying reliable biomarkers for evaluating probiotic efficacy or the axes with other organs are highlighted. Overall, Bacillus probiotics are seen as promising, sustainable alternatives to antibiotics with significant potential for future research to optimize their use and understand their mechanisms within the context of animal production and health.
Keywords: probiotic, Bacillus, Livestock, Monogastric, Health
Received: 23 Sep 2025; Accepted: 18 Nov 2025.
Copyright: © 2025 Vieco-Saiz, Lemâle, Evans, Quinteiro-Filho, Mellouk, Consuegra, Yakout and Goossens. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tim Goossens, tim.goossens@adisseo.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.