SYSTEMATIC REVIEW article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
This article is part of the Research TopicGut Microbiota and Women’s Health: Insights from Basic Research to Clinical ApplicationsView all 5 articles
Research hotspots and trends on endometriosis and gut microbiome
Provisionally accepted
- 1Shihezi University School of Medicine, Shihezi, China
- 2Shaodong Traditional Chinese Medicine Hospital, Shaoyang, China
- 3Jiamusi University, Jiamusi, China
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Background: Endometriosis is a chronic inflammatory gynecological disease, and its pathogenesis involves multiple factors (genetics, immunity, endocrine, etc.), but its specific mechanism is unknown. Studies indicate that the gut microbiome is involved in the pathogenesis of endometriosis. Therefore, this study aims to comprehensively and systematically analyze the current research status of endometriosis and gut microbiome, and explore future research priorities. Methods: Articles published in the Web of Science Core Collection (WoSCC) and PubMed databases through December 31, 2024, focusing on endometriosis and the gut microbiome, were analyzed using CiteSpace, VOSviewer, and Bibliometrix. Results: The WOSCC dataset included 84 articles, with annual publication and citation counts showing an upward trend. Ding J and Kommagani R were the most prolific authors. China led publication output (33 articles), followed by the United States (14 articles). Major contributing institutions were based in China and the U.S. Prominent keywords included "estrogen" and "vaginal microbiome." Validation using the PubMed database, which included 78 articles, produced results broadly consistent with those from WOSCC. Conclusion: This study provides key insights into the field of gut microbiome and endometriosis, highlighting research hotspots and directions. Future research should employ a prospective study and mechanistic experiments to elucidate the underlying mechanisms.
Keywords: Endometriosis, gut microbiome, estrogen, vaginal microbiome, Bibliometrics
Received: 03 Oct 2025; Accepted: 24 Nov 2025.
Copyright: © 2025 Luo, Zhao, Chen, Jie, Liu, Liu, Zhang, Wang and Hou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hui Zhao, 15200304868@163.com
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