Frontiers in Molecular Biosciences

Original Research

Published on 27 Jan 2026

A validated LC-ESI-MS/MS assay for simultaneous plasma quantification of 11 antimicrobials to support personalized dosing in critically ill children

in Metabolomics

Yuan-Yuan Zhang
Jie Wang
Hong-Li Guo
Shi-Yu Wu
Hai-Feng Zhang
Peng-Fei Zheng
Hong-Jun Miao
Feng Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1745458

439 views

Original Research

Accepted on 26 Jan 2026

Integrative multi-omics analysis reveals cellular and molecular insights into gestational diabetes mellitus

in Molecular Diagnostics and Therapeutics

Niankun Chen
Lottie Hung
Shaole Shi
Shanshan Zhao
Chumei Zeng
Yihong Huang
Huilin Xu
Lixia Shen
Dongyu Wang
Zilian Wang

Frontiers in Molecular Biosciences

141 views

Review

Accepted on 26 Jan 2026

The Role of Exosomes in Ankylosing Spondylitis: From Biological Features and Functional Cargo to Clinical Applications

in Cellular Biochemistry

Hanying Yuan
Jia Xu
Youyu Zhang
Xuan Xi
Heng Pan
Shujing Zhao
Kaixu Li
De Li
Yan LU

Frontiers in Molecular Biosciences

142 views

Original Research

Accepted on 26 Jan 2026

Unlocking Personalized Endometrial Cancer Treatment: The Critical Role of the BBIRE Biobank in Sample Collection and Distribution

in Molecular Diagnostics and Therapeutics

Valentina Bruno
Martina Betti
Ludovica Ciuffreda
Ana Maria Brindusa Arteni
Margherita Ferretti
Federica Rossi
Celeste Accetta
Chiara Mando
Valentina Laquintana
Francesca De Nicola

Frontiers in Molecular Biosciences

376 views

Review

Published on 26 Jan 2026

Advances in cardiovascular supplementation: mechanisms, efficacy, and clinical perspectives

in Micronutrient Biology

Xun Wu
Tanwei Fang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1699492

1,976 views

Original Research

Accepted on 23 Jan 2026

Preclinical evaluation of waste-derived pomegranate extract (PWE) as a potential preventing and therapeutic agent for benign prostatic hyperplasia

in Cellular Biochemistry

Valeria Consoli
Agata Grazia D'Amico
Claudio Mario Russo
Emanuele Foderà
DANIELA PASSARELLA
Antonio Pecorino
Velia D'Agata
Luca Vanella
Valeria Sorrenti

Frontiers in Molecular Biosciences

219 views

Review

Published on 23 Jan 2026

S100A12 drives inflammatory and metabolic reprogramming in sepsis-associated acute kidney injury

in Molecular Diagnostics and Therapeutics

Huanqin Liu
Yanan Lv
Qingjie Xue
Jikui Shi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1741799

647 views

Review

Published on 23 Jan 2026

Advances in protein dot blot: principles, technical specifics, applications, and future perspectives

in Protein Biochemistry for Basic and Applied Sciences

Juan Lu
Feng-yi Mai
Xin-yu Li
Wen-tao Yang
Jing-rong Liang
Xing-long Li
Jie Guo
Chen-guang Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1768231

723 views

Original Research

Published on 23 Jan 2026

Investigating circulating expression profile for H19, MEG3, and MIAT long noncoding RNAs with miR-135a and miR-29a in chronic kidney disease and renal hemodialysis patients: interrelations with serum sclerostin

in RNA Networks and Biology

Marwa A. Dahpy
Marwa K. Khairallah
Rania Naguib
Mona A. Khalil
Salwa Seif Eldin
Marwa A. Sabet
Amira A. Kamel

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1703108

539 views

Original Research

Accepted on 22 Jan 2026

Genetic Constraints on Protein Loop Evolution: Out-of-Frame Stop Codons limit Bacillus subtilis Stationary-phase mutagenesis

in Genome Organization and Dynamics

Carmen Vallin
Mario Pedraza-Reyes
Eduardo A Robleto

Frontiers in Molecular Biosciences

168 views

Original Research

Accepted on 22 Jan 2026

Deciphering Skeletal Muscle Trait Differences Between Chinese a nd Western Pig Breeds Based on 4D-label Ubiquitin-Proteomics

in Protein Biochemistry for Basic and Applied Sciences

Yunlei Li
Zikai AI
Yun Zhang
Mingfu Xiong
Jingyang DONG
Yilong YAO
Yaxing LIU
Jian LI
Yongjin ZHANG
Xinhao FAN

Frontiers in Molecular Biosciences

138 views

Original Research

Accepted on 22 Jan 2026

Untargeted Metabolomics Reveals Immune-Metabolic Signatures in Established Cases of Rheumatoid Arthritis

in Metabolomics

Afshan Masood
Reem Al Malki
Abeer Malkawi
Maha Al Mogren
Amal Jaafar
Hicham Benabdelkamel
Assim A Alfadda
Amina Fallata
Abdurhman S. Alarfaj
Mohamed Siaj

Frontiers in Molecular Biosciences

184 views

Methods

Accepted on 21 Jan 2026

Quantum Chemical Profiling of Protein Mutations via Fragment-Based DFT

in Biological Modeling and Simulation

Alejandro Leyva
Muhammed Khalid Khan Niazi

Frontiers in Molecular Biosciences

227 views

Review

Accepted on 21 Jan 2026

Heterogeneous Regulation of Fibroblast Growth Factor 23 in Acute Kidney Injury, Chronic Kidney Disease, and Polycystic Kidney Disease: Mechanisms, Diagnostic Utility, and Clinical Implications

in Molecular Diagnostics and Therapeutics

Xiaohua Hu
Bo Yang
Nanmei Liu
Haimin Chen
Min Min
Cheng Xue

Frontiers in Molecular Biosciences

157 views

Original Research

Accepted on 20 Jan 2026

Predicting Drug–Drug Interactions Between Ayahuasca Alkaloids and SSRIs Using Physiologically Based Pharmacokinetic Modeling

in Biological Modeling and Simulation

Gabriella de Souza Gomes Ribeiro
Beatriz Aparecida Passos Bismara Paranhos
Fabiane Dörr
Mauricio Yonamine
Bianca Villanova
Lorena Terene Lopes Guerra
Adrieli Oliveira Raminelli
Jose Augusto Silva Reis
Caio Cesar de Paula
Anna Beatriz Vicentini Zacharias

Frontiers in Molecular Biosciences

397 views

Original Research

Published on 20 Jan 2026

Gene expression profiling identifies ferroptosis-related genes and pathways in human colon cancers cell lines

in Molecular Diagnostics and Therapeutics

M. Balik-Meisner
D. Phadke
D. Mav
R. Shah
K. R. Shockley
Carri Murphy
Erik J. Tokar
Birandra K. Sinha

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1680206

825 views

Original Research

Accepted on 19 Jan 2026

Spinal cord injury–induced overflow incontinence reshapes the activin–follistatin–inhibin axis in mouse bladder and kidney

in Cellular Biochemistry

Yucheng Shen
Shengkai Yang
Hai Zhou
Yongkun Zhu
Zhong Wang
Weimin Jiang

Frontiers in Molecular Biosciences

260 views

Original Research

Accepted on 19 Jan 2026

Creatinine, Leucine, and Tetrahydrocorticosterone Emerge as Potential Biomarkers for the Diagnosis of Sarcopenic Osteoarthritis in Middle-Aged and Elderly Individuals: a cross-sectional exploratory study

in Metabolomics

Huihui Wu
Hui Gao
Liang Guo
Xinyu Feng
Zhishen Zhang
Zhi Wang
Haihong Chen
Yiding Zhao

Frontiers in Molecular Biosciences

155 views

Editorial

Published on 19 Jan 2026

Editorial: Molecular mechanisms and precision medicine in rare diseases

in Cellular Biochemistry

Hector Rodriguez Cetina Biefer
Abdallah Elkhal
Mohamed Taha Moutaoufik

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1778169

1,023 views

Original Research

Accepted on 16 Jan 2026

Comprehensive first–trimester targeted metabolomics for early prediction and understanding of GDM pathophysiology

in Metabolomics

Patrycja Mojsak
Adrian Godlewski
Krzysztof Sołowiej
Agnieszka Kulczynska-Przybik
Sandra Chmielewska
Barbara Mroczko
Barbara Szelachowska
Adam Krętowski
Michal Ciborowski

Frontiers in Molecular Biosciences

263 views

Original Research

Published on 16 Jan 2026

The predictive role of protease-activated receptor (PAR-1) polymorphisms and activated microplatelets on the severity of atherosclerosis – preliminary studies

in Molecular Diagnostics and Therapeutics

Urszula Jakobsche-Policht
Agnieszka Bronowicka-Szydełko
Rajmund Adamiec
Dorota Bednarska-Chabowska
Łukasz Lewandowski
Rafał Małecki
Kinga Gostomska-Pampuch
Joanna Adamiec-Mroczek
Marta Myszka-Kozłowska
Dagmara Baczyńska

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1662954

810 views

Original Research

Published on 16 Jan 2026

Single-cell multi-omics sequencing reveals the immunological disturbance underlying Kawasaki disease

in Molecular Diagnostics and Therapeutics

Xue Fan
Shuang Deng
Yuehao Xu
Bin Wang
Xin Guo
Jinwen Liao
Mingguo Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1758948

841 views

Original Research

Published on 16 Jan 2026

Alterations in protein N-glycosylation confer vanadate resistance in Ogataea polymorpha mutants defective in phosphomannosylation

in Glycoscience

Maria Pakhomova
Azamat Karginov
Maria Kulakova
Polina Vladimirova
Olga Mitkevich
Michael Agaphonov

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1741711

570 views

Original Research

Accepted on 15 Jan 2026

A label-free microLC-SWATH-MS methodology with immunoaffinity depletion of high abundant serum proteins for quantitative proteomic comparison of fresh-frozen human normal breast tissue and tumor clinical specimens

in Molecular Diagnostics and Therapeutics

Katarzyna Macur
Aleksandra Ewa Bogucka
Anna Fel-Tukalska
Jarosław Skokowski
Stanisław Ołdziej
Paulina Czaplewska

Frontiers in Molecular Biosciences

334 views

5,856 articles

articles

A validated LC-ESI-MS/MS assay for simultaneous plasma quantification of 11 antimicrobials to support personalized dosing in critically ill children

Integrative multi-omics analysis reveals cellular and molecular insights into gestational diabetes mellitus

The Role of Exosomes in Ankylosing Spondylitis: From Biological Features and Functional Cargo to Clinical Applications

Unlocking Personalized Endometrial Cancer Treatment: The Critical Role of the BBIRE Biobank in Sample Collection and Distribution

Advances in cardiovascular supplementation: mechanisms, efficacy, and clinical perspectives

Preclinical evaluation of waste-derived pomegranate extract (PWE) as a potential preventing and therapeutic agent for benign prostatic hyperplasia

S100A12 drives inflammatory and metabolic reprogramming in sepsis-associated acute kidney injury

Advances in protein dot blot: principles, technical specifics, applications, and future perspectives

Investigating circulating expression profile for H19, MEG3, and MIAT long noncoding RNAs with miR-135a and miR-29a in chronic kidney disease and renal hemodialysis patients: interrelations with serum sclerostin

Genetic Constraints on Protein Loop Evolution: Out-of-Frame Stop Codons limit Bacillus subtilis Stationary-phase mutagenesis

Deciphering Skeletal Muscle Trait Differences Between Chinese a nd Western Pig Breeds Based on 4D-label Ubiquitin-Proteomics

Untargeted Metabolomics Reveals Immune-Metabolic Signatures in Established Cases of Rheumatoid Arthritis

Quantum Chemical Profiling of Protein Mutations via Fragment-Based DFT

Heterogeneous Regulation of Fibroblast Growth Factor 23 in Acute Kidney Injury, Chronic Kidney Disease, and Polycystic Kidney Disease: Mechanisms, Diagnostic Utility, and Clinical Implications

Predicting Drug–Drug Interactions Between Ayahuasca Alkaloids and SSRIs Using Physiologically Based Pharmacokinetic Modeling

Gene expression profiling identifies ferroptosis-related genes and pathways in human colon cancers cell lines

Spinal cord injury–induced overflow incontinence reshapes the activin–follistatin–inhibin axis in mouse bladder and kidney

Creatinine, Leucine, and Tetrahydrocorticosterone Emerge as Potential Biomarkers for the Diagnosis of Sarcopenic Osteoarthritis in Middle-Aged and Elderly Individuals: a cross-sectional exploratory study

Editorial: Molecular mechanisms and precision medicine in rare diseases

Comprehensive first–trimester targeted metabolomics for early prediction and understanding of GDM pathophysiology

The predictive role of protease-activated receptor (PAR-1) polymorphisms and activated microplatelets on the severity of atherosclerosis – preliminary studies

Single-cell multi-omics sequencing reveals the immunological disturbance underlying Kawasaki disease

Alterations in protein N-glycosylation confer vanadate resistance in Ogataea polymorpha mutants defective in phosphomannosylation

A label-free microLC-SWATH-MS methodology with immunoaffinity depletion of high abundant serum proteins for quantitative proteomic comparison of fresh-frozen human normal breast tissue and tumor clinical specimens