Frontiers in Molecular Biosciences

Original Research

Published on 17 Dec 2025

TNFα protein, DNA methylation, mRNA and miRNA expression evaluation in multiple sclerosis

in Structural Biology

E. Costantini
N. H. Greig
L. Aielli
P. C. Silva
M. Di Carlo
F. Konstantinidou
M. Reale

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1730177

210 views

Original Research

Accepted on 04 Dec 2025

Reformulation of the Protein Databank for Real-time Search of Geometrical Attributes of Protein Structures

in Structural Biology

Musa Azeem
Christopher Lee
Aaron Hein
Christopher Ott
Homayoun Valafar

Frontiers in Molecular Biosciences

Review

Published on 04 Dec 2025

Recent progress in human telomerase structure and its therapeutic targeting

in Structural Biology

Muaath Ebrahim Almansoori
Abdulrahman Awad
Sarah Dhaiban
Mohammed Turki Alduhoori
Humayun Sharif
Abdulrahim Sajini

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1681988

915 views

Original Research

Published on 26 Nov 2025

Identification of lysozyme in Venetin-1 nanoparticle from the coelomic fluid of the earthworm Dendrobaena veneta

in Structural Biology

Marta J. Fiołka
Magdalena Dryglewska
Kinga Lewtak
Michał Rawski
Tomasz Buchwald
Ewa Skwarek
Sachin Kote
Jakub Faktor
Weronika Ścibek-Rejmontowska
Paulina Czaplewska

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1719519

952 views

Original Research

Published on 21 Nov 2025

A DNA2 mutation in the ATP-binding motif identified in a diagnostically unresolved individual

in Structural Biology

Keisuke Saito
Yukiko Yatsuka
Ayuno Kawakami
Shinichiro Kumagaya
Nana Akiyama
Yasushi Okazaki
Kei Murayama
Hiroshi Ishikita

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1706392

992 views

Editorial

Published on 20 Nov 2025

Editorial: Breakthroughs in Cryo-EM with machine learning and artificial intelligence

in Structural Biology

Edward T. Eng
Sonya M. Hanson
Ruben Sanchez-Garcia

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1739481

871 views

Correction

Published on 07 Nov 2025

Correction: Dihedral angle measurements for structure determination by biomolecular solid-state NMR spectroscopy

in Structural Biology

Patrick C. A. van der Wel

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1716334

415 views

Review

Published on 29 Oct 2025

Molecular mechanisms and computational insights into human SGLTs: advancing toward selective SGLT1 inhibition

in Structural Biology

Nadhiri Kaijage
Sebastian Kraszewski

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1668400

1,509 views

Review

Accepted on 28 Oct 2025

Connecting the dots: deep learning-based automated model building methods in cryo-EM

in Structural Biology

Harsh Bansia
Amedee des Georges

Frontiers in Molecular Biosciences

251 views

Review

Published on 23 Oct 2025

High-resolution protein modeling through Cryo-EM and AI: current trends and future perspectives – a review

in Structural Biology

Gnanaprakash Jeyaraj
Anith Kumar Rajendran
Kuppusamy Sathishkumar
Bader O. Almutairi
Aanand Vadivelu
Santosh Chokkakula
Yanyang Tu
Weimim Xie

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1688455

3,643 views

Original Research

Published on 24 Sep 2025

Interactions between membrane-bound streptococcal alpha-enolase and human plasminogen captured through cryogenic-electron microscopy

in Structural Biology

Sheiny Tjia-Fleck
Bradley M. Readnour
Zhong Liang
Yetunde A. Ayinuola
Francis J. Castellino

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1666748

2,213 views

Correction

Published on 08 Sep 2025

Correction: Editorial: Structural studies of bacteria and viruses

in Structural Biology

Frontiers Production Office

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1697351

1,267 views

Editorial

Published on 24 Jun 2025

Editorial: Methodological advancements and improvements in structural biology

in Structural Biology

Annalisa Pastore

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1625111

1,651 views

Editorial

Published on 30 Apr 2025

Editorial: Structural studies of bacteria and viruses

in Structural Biology

Annalisa Pastore

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1605596

1,770 views

Original Research

Published on 16 Apr 2025

Structure-guided virtual screening reveals phytoconstituents as potent cathepsin B inhibitors: Implications for cancer, traumatic brain injury, and Alzheimer’s disease

in Structural Biology

Nageeb Hassan
Mohammad Furkan
Mohd Shahnawaz Khan
Azna Zuberi
Moyad Shahwan
Anas Shamsi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1581711

2,481 views
2 citations

Brief Research Report

Published on 16 Apr 2025

In silico characterization of the interaction of AKR1B1 with the deacetylase activation domain (DAD)

in Structural Biology

Francisco J. Gómez-Zaldívar
Luis Córdova-Bahena
Angel J. Ruiz-Moreno
Paolo Ceppi
Marco A. Velasco-Velázquez

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1562206

2,067 views

Original Research

Published on 31 Mar 2025

Highly conserved ion binding sites are not all functionally relevant in mouse KCC4

in Structural Biology

Lisa Becker
Jens Hausmann
Rieke Wellpott
Anna-Maria Hartmann

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1556250

1,641 views

Original Research

Published on 10 Mar 2025

Computational electrostatic engineering of nanobodies for enhanced SARS−CoV−2 receptor binding domain recognition

in Structural Biology

Zafar Iqbal
Muhammad Asim
Umair Ahmad Khan
Neelam Sultan
Irfan Ali

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1512788

3,339 views

Correction

Published on 28 Nov 2024

Corrigendum: Shedding light on the DICER1 mutational spectrum of uncertain significance in malignant neoplasms

in Structural Biology

D. S. Bug
I. S. Moiseev
Yu. B. Porozov
N. V. Petukhova

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1517143

1,053 views

Editorial

Published on 16 Oct 2024

Editorial: Cryogenic electron microscopy of infectious diseases

in Structural Biology

Jiho Yoo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1506197

1,924 views
1 citation

Original Research

Published on 15 Oct 2024

Identification of potential bioactive phytochemicals for the inhibition of platelet-derived growth factor receptor β: a structure-based approach for cancer therapy

in Structural Biology

Insan Habib
Md Nayab Sulaimani
Deeba Shamim Jairajpuri
Afzal Hussain
Taj Mohammad
Mohamed F. Alajmi
Anas Shamsi
Md Imtaiyaz Hassan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1492847

3,083 views
8 citations

Original Research

Published on 03 Oct 2024

Shedding light on the DICER1 mutational spectrum of uncertain significance in malignant neoplasms

in Structural Biology

D. S. Bug
I. S. Moiseev
Yu. B. Porozov
N. V. Petukhova

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1441180

2,761 views
2 citations

Original Research

Published on 01 Oct 2024

Semantic segmentation-based detection algorithm for challenging cryo-electron microscopy RNP samples

in Structural Biology

J. Vargas
A. Modrego
H. Canabal
J. Martin-Benito

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1473609

1,895 views
1 citation

Original Research

Published on 27 Sep 2024

Structure features of Streptococcus pneumoniae FabG and virtual screening of allosteric inhibitors

in Structural Biology

Kaimin Xu
Jianliang Zhong
Jing Li
Yulu Cao
Lai Wei

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1472252

5,731 views

496 articles

articles

TNFα protein, DNA methylation, mRNA and miRNA expression evaluation in multiple sclerosis

Reformulation of the Protein Databank for Real-time Search of Geometrical Attributes of Protein Structures

Recent progress in human telomerase structure and its therapeutic targeting

Identification of lysozyme in Venetin-1 nanoparticle from the coelomic fluid of the earthworm Dendrobaena veneta

A DNA2 mutation in the ATP-binding motif identified in a diagnostically unresolved individual

Editorial: Breakthroughs in Cryo-EM with machine learning and artificial intelligence

Correction: Dihedral angle measurements for structure determination by biomolecular solid-state NMR spectroscopy

Molecular mechanisms and computational insights into human SGLTs: advancing toward selective SGLT1 inhibition

Connecting the dots: deep learning-based automated model building methods in cryo-EM

High-resolution protein modeling through Cryo-EM and AI: current trends and future perspectives – a review

Interactions between membrane-bound streptococcal alpha-enolase and human plasminogen captured through cryogenic-electron microscopy

Correction: Editorial: Structural studies of bacteria and viruses

Editorial: Methodological advancements and improvements in structural biology

Editorial: Structural studies of bacteria and viruses

Structure-guided virtual screening reveals phytoconstituents as potent cathepsin B inhibitors: Implications for cancer, traumatic brain injury, and Alzheimer’s disease

In silico characterization of the interaction of AKR1B1 with the deacetylase activation domain (DAD)

Highly conserved ion binding sites are not all functionally relevant in mouse KCC4

Computational electrostatic engineering of nanobodies for enhanced SARS−CoV−2 receptor binding domain recognition

Corrigendum: Shedding light on the DICER1 mutational spectrum of uncertain significance in malignant neoplasms

Editorial: Cryogenic electron microscopy of infectious diseases

Identification of potential bioactive phytochemicals for the inhibition of platelet-derived growth factor receptor β: a structure-based approach for cancer therapy

Shedding light on the DICER1 mutational spectrum of uncertain significance in malignant neoplasms

Semantic segmentation-based detection algorithm for challenging cryo-electron microscopy RNP samples

Structure features of Streptococcus pneumoniae FabG and virtual screening of allosteric inhibitors