Frontiers in Molecular Neuroscience

Review

Published on 12 Feb 2026

Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration

in Brain Disease Mechanisms

Raphael P. Ricci
Cheng Xiang Foo
Katharina Ronacher
Carlie L. Cullen

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1709065

168 views

Review

Accepted on 11 Feb 2026

Lactate and Cognition: A Dual Modulator

in Brain Disease Mechanisms

Wen Yang
Yu Xu
Kunhua Wang

Frontiers in Molecular Neuroscience

Correction

Published on 11 Feb 2026

Correction: Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament

in Brain Disease Mechanisms

Elaine K. Hebda-Bauer
Megan H. Hagenauer
Daniel B. Munro
Peter Blandino Jr.
Fan Meng
Keiko Arakawa
John D. H. Stead
Apurva S. Chitre
A. Bilge Ozel
Pejman Mohammadi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1784625

200 views

Opinion

Published on 11 Feb 2026

Peroxisomes and the nervous system: progress and challenges in neuroinflammation and cell-specific functions

in Molecular Signalling and Pathways

Francesca Di Cara
Stéphane Savary

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1745086

521 views

Editorial

Published on 11 Feb 2026

Editorial: Proteostasis disruption in neurodegenerative disorders: mechanisms and treatment strategies

in Brain Disease Mechanisms

Jonasz Jeremiasz Weber
Hiroaki Taniguchi
Maxim Sokolov

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1796704

391 views

Original Research

Accepted on 10 Feb 2026

Polyclonal glycine receptor autoantibodies: A challenge for personalized epitope characterization

in Brain Disease Mechanisms

Anna-Lena Wiessler
Inken Stahl
Natascha Schaefer
Vera Rauschenberger
Ivan Talucci
Hans Maric
Betül Baykan
Erdem Tüzün
Claudia Sommer
Carmen Villmann

Frontiers in Molecular Neuroscience

Original Research

Accepted on 10 Feb 2026

Modulation of apolipoprotein E (ApoE) receptor-2 by ApoE4, amyloid ꞵ-peptide, reelin, and secreted amyloid precursor protein: a common point of impact in Alzheimer's disease pathogenesis

in Neuroplasticity and Development

Steven W Barger
Andrea M Moerman-Herzog

Frontiers in Molecular Neuroscience

Original Research

Published on 10 Feb 2026

Emerging role of KDM5C in X-linked intellectual disability based on human genetic data and zebrafish models

in Brain Disease Mechanisms

Baoqiong Liao
Meihuan Chen
Yun Huang
Mei Shuai
Liangpu Xu
Shuwen He
Hailong Huang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1750311

468 views

Original Research

Accepted on 09 Feb 2026

Notch Signaling Inhibition Attenuates Epileptogenesis and Hippocampal Damage Without Altering Mossy Fiber Sprouting in Adolescent Rats Post-Status Epilepticus

in Brain Disease Mechanisms

Ping Yuan
Li Jiang
Li Jiang

Frontiers in Molecular Neuroscience

Systematic Review

Accepted on 09 Feb 2026

Neuroplasticity and Recovery of the Brain Affected by Substance Use Disorder: Multilevel Mechanisms and New Therapeutic Strategies (2020–2025)

in Neuroplasticity and Development

Roberto Estrada Medina
Berle Estalin Briones-Llamoctanta
Josué Edison Turpo-Chaparro

Frontiers in Molecular Neuroscience

104 views

Hypothesis and Theory

Accepted on 05 Feb 2026

Integrating neural organoids and AI: Increasing the risk of artificial consciousness or medical malpractice?

in Methods and Model Organisms

Alexander R Harris
Patrick McGivern
Kyle C A Wedgwood
Frederic Gilbert

Frontiers in Molecular Neuroscience

110 views

Original Research

Published on 05 Feb 2026

Oxymatrine-associated protection in an MPTP mouse model is accompanied by increased miR-141-3p and reduced HMGB1

in Brain Disease Mechanisms

Ping Gan
Qi Zhao
Xing Yi
Yi-Ming Hua
Yu-Fang Ding
Zhi-Mei Huang
Xing Ye
Jian Wu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1731850

491 views

Original Research

Published on 04 Feb 2026

KCC2 phosphorylation dynamics relate to oligomerization during development and after spinal cord injury

in Molecular Signalling and Pathways

Sylvie Liabeuf
Cecile Brocard
Jacques-Olivier Coq
Laurent Vinay
Frederic Brocard

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1745037

520 views

Original Research

Accepted on 03 Feb 2026

Clinical and Genetic Determinants of Glioblastoma Multiforme Survival: A Retrospective Study

in Brain Disease Mechanisms

Julia Lara Gutiérrez-Arroyo
Pia Gallego Porcar
Elvira Carbonell Martínez
Luis German González Bonet
Maria Victoria Ibañez
María Díaz-Ruiz
Hugo Caballero-Arzapalo
Ariadna Soto
Guillermo Garcia-Oriola
José María Borras-Moreno

Frontiers in Molecular Neuroscience

230 views

Original Research

Accepted on 02 Feb 2026

Coactivation of CB1 and GPR55 promotes GABA release and motor behavior at striatonigral terminals through increased dimerization induced by CB1 activation

in Molecular Signalling and Pathways

José Arturo Avalos-Fuentes
Rodolfo Sánchez-Zavaleta
Ihosvany Rodríguez Pérez
Rafael Jijón-Lorenzo
Refugio Cruz-Trujillo
Maria Fernanda González de la Torre
Martha Abigail Villareal Zuñiga
Benjamín Florán

Frontiers in Molecular Neuroscience

163 views

Opinion

Published on 02 Feb 2026

Lysosome trafficking across intracellular and intercellular networks in the brain

in Brain Disease Mechanisms

Dylan T. Murphy
Chih Hung Lo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1755292

817 views

Original Research

Accepted on 29 Jan 2026

T2-FLAIR hyperintensities in the inferior cerebellar peduncles and their association with clinical symptoms, molecular and MRI markers in male FMR1 premutation carriers

in Brain Disease Mechanisms

Andrea Elias
Irene Paracuellos-Ayala
Jun Yi Wang
Kyoungmi Kim
Flora Tassone
Andrea Schneider
David Hessl
Susan M Rivera
Randi Jenssen Hagerman

Frontiers in Molecular Neuroscience

274 views

Original Research

Published on 29 Jan 2026

The Nodding syndrome cerebrospinal fluid proteome: a lens into neurodevelopmental failure consistent with environmentally triggered MECP2 dysregulation?

in Brain Disease Mechanisms

Raquel Valdes Angues
Caesar Okot
Keith D. Zientek
Phillip A. Wilmarth
Ashok P. Reddy
Alfred Lucid Blair Odong
Valerie S. Palmer
Lucy Kipwola Abwola
Ensio Ogal
Geoffrey Okello

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1717920

607 views

Original Research

Published on 29 Jan 2026

Transcriptional and neurotransmitter signatures associated with regional gray matter alterations in juvenile myoclonic epilepsy

in Molecular Signalling and Pathways

Xiao-Yi Liu
Han Xu
Si-Yu Gu
Hu-Cheng Yang
Chuan-Xu Luo
Shu Wang
Wen-Hui Li
Ping-Lei Pan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1693722

490 views

Review

Accepted on 28 Jan 2026

Mesenchymal Stem Cells and the Central Nervous System: Historical Perspectives and Future Directions

in Brain Disease Mechanisms

Christopher Yates Mazurek
Julia Krystyna Kaniuk
Christopher Ahuja

Frontiers in Molecular Neuroscience

608 views

Original Research

Accepted on 28 Jan 2026

Temporal Lobe Epilepsy is associated with Neuroinflammation, Extracellular Matrix Remodeling, and Synaptic Protein Alterations

in Brain Disease Mechanisms

Sophia Auer
Lucas Hoffmann
Martin Schicht
Ingmar Blümcke
Friedrich Paulsen

Frontiers in Molecular Neuroscience

174 views

Systematic Review

Accepted on 26 Jan 2026

TDP-43 related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA Damage Response: a systematic review and narrative synthesis

in Brain Disease Mechanisms

Seham Almalki
Mohamed Salama
Matthew J Taylor
Zubair Ahmed
Richard Tuxworth

Frontiers in Molecular Neuroscience

345 views

Opinion

Published on 26 Jan 2026

Multilayer modulation of the proteasome: new strategies for neuroprotection

in Brain Disease Mechanisms

Maxim Sokolov
Hiroaki Taniguchi
Jonasz Jeremiasz Weber

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1748434

697 views

Original Research

Accepted on 23 Jan 2026

Dysregulated lipid metabolism and hypomyelination in postnatal peroxisome-deficient Pex2 knockout Zellweger mice

in Molecular Signalling and Pathways

Tanja Eberhart
Khanichi N Charles
Brenda Salumbides-Torres
Nia Price
Steven J. Fliesler
Phyllis L Faust
Werner Josef Kovacs

Frontiers in Molecular Neuroscience

248 views

4,350 articles

articles

Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration

Lactate and Cognition: A Dual Modulator

Correction: Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament

Peroxisomes and the nervous system: progress and challenges in neuroinflammation and cell-specific functions

Editorial: Proteostasis disruption in neurodegenerative disorders: mechanisms and treatment strategies

Polyclonal glycine receptor autoantibodies: A challenge for personalized epitope characterization

Modulation of apolipoprotein E (ApoE) receptor-2 by ApoE4, amyloid ꞵ-peptide, reelin, and secreted amyloid precursor protein: a common point of impact in Alzheimer's disease pathogenesis

Emerging role of KDM5C in X-linked intellectual disability based on human genetic data and zebrafish models

Notch Signaling Inhibition Attenuates Epileptogenesis and Hippocampal Damage Without Altering Mossy Fiber Sprouting in Adolescent Rats Post-Status Epilepticus

Neuroplasticity and Recovery of the Brain Affected by Substance Use Disorder: Multilevel Mechanisms and New Therapeutic Strategies (2020–2025)

Integrating neural organoids and AI: Increasing the risk of artificial consciousness or medical malpractice?

Oxymatrine-associated protection in an MPTP mouse model is accompanied by increased miR-141-3p and reduced HMGB1

KCC2 phosphorylation dynamics relate to oligomerization during development and after spinal cord injury

Clinical and Genetic Determinants of Glioblastoma Multiforme Survival: A Retrospective Study

Coactivation of CB1 and GPR55 promotes GABA release and motor behavior at striatonigral terminals through increased dimerization induced by CB1 activation

Lysosome trafficking across intracellular and intercellular networks in the brain

T2-FLAIR hyperintensities in the inferior cerebellar peduncles and their association with clinical symptoms, molecular and MRI markers in male FMR1 premutation carriers

The Nodding syndrome cerebrospinal fluid proteome: a lens into neurodevelopmental failure consistent with environmentally triggered MECP2 dysregulation?

Transcriptional and neurotransmitter signatures associated with regional gray matter alterations in juvenile myoclonic epilepsy

Mesenchymal Stem Cells and the Central Nervous System: Historical Perspectives and Future Directions

Temporal Lobe Epilepsy is associated with Neuroinflammation, Extracellular Matrix Remodeling, and Synaptic Protein Alterations

TDP-43 related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA Damage Response: a systematic review and narrative synthesis

Multilayer modulation of the proteasome: new strategies for neuroprotection

Dysregulated lipid metabolism and hypomyelination in postnatal peroxisome-deficient Pex2 knockout Zellweger mice